The Complement Regulatory Protein CD46 Deficient Mouse Spontaneously Develops Dry-Type Age-Related Macular Degeneration-Like Phenotype (Q42044277)

15 October 2017

The Complement Regulatory Protein CD46 Deficient Mouse Spontaneously Develops Dry-Type Age-Related Macular Degeneration-Like Phenotype (English)

1 reference

15 October 2017

Valeriy V Lyzogubov

1 reference

15 October 2017

Puran S Bora

1 reference

15 October 2017

Xiaobo Wu

1 reference

15 October 2017

Leah E Horn

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15 October 2017

Ryan de Roque

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15 October 2017

Xeniya V Rudolf

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15 October 2017

John P Atkinson

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15 October 2017

Nalini S Bora

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15 October 2017

language of work or name

English

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publication date

10 June 2016

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The American Journal of Pathology

15 October 2017

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15 October 2017

186

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15 October 2017

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15 October 2017

2088-2104

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describes a project that uses

15 October 2017

ImageJ

1 reference

11 June 2022

https://www.ebi.ac.uk/europepmc/webservices/rest/PMC4973660/fullTextXML

inferred from PubMed Central ID database lookup

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Rare genetic variants in the CFI gene are associated with advanced age-related macular degeneration and commonly result in reduced serum factor I levels

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Ccl2, Cx3cr1 and Ccl2/Cx3cr1 chemokine deficiencies are not sufficient to cause age-related retinal degeneration.

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The bisretinoids of retinal pigment epithelium

5 June 2018

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5 June 2018

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Relationship between complement membrane attack complex, chemokine (C-C motif) ligand 2 (CCL2) and vascular endothelial growth factor in mouse model of laser-induced choroidal neovascularization

5 June 2018

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Polyethylene Glycol (PEG)-induced Mouse Model of Choroidal Neovascularization

5 June 2018

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Pathway-based therapies for age-related macular degeneration: an integrated survey of emerging treatment alternatives

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5 June 2018

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Recombinant membrane-targeted form of CD59 inhibits the growth of choroidal neovascular complex in mice.

5 June 2018

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Transgenic mice expressing variants of complement factor H develop AMD-like retinal findings

5 June 2018

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Animals as models of age-related macular degeneration: an imperfect measure of the truth

5 June 2018

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The pivotal role of the complement system in aging and age-related macular degeneration: hypothesis re-visited

5 June 2018

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The drusenlike phenotype in aging Ccl2-knockout mice is caused by an accelerated accumulation of swollen autofluorescent subretinal macrophages.

5 June 2018

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A human apoB100 transgenic mouse expresses human apoB100 in the RPE and develops features of early AMD.

5 June 2018

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Forecasting age-related macular degeneration through the year 2050: the potential impact of new treatments

5 June 2018

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Autophagy and exosomes in the aged retinal pigment epithelium: possible relevance to drusen formation and age-related macular degeneration

5 June 2018

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Alcohol and nicotine consumption exacerbates choroidal neovascularization by modulating the regulation of complement system

5 June 2018

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Chronic cigarette smoke causes oxidative damage and apoptosis to retinal pigmented epithelial cells in mice

5 June 2018

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Retinal dysfunction and progressive retinal cell death in SOD1-deficient mice

5 June 2018

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Ceruloplasmin/hephaestin knockout mice model morphologic and molecular features of AMD

5 June 2018

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Immunological protein expression profile in Ccl2/Cx3cr1 deficient mice with lesions similar to age-related macular degeneration

5 June 2018

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The role of complement in ocular pathology

5 June 2018

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Complement factor H deficiency in aged mice causes retinal abnormalities and visual dysfunction

5 June 2018

1 reference

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Murine ccl2/cx3cr1 deficiency results in retinal lesions mimicking human age-related macular degeneration.

5 June 2018

1 reference

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Molecular genetics of AMD and current animal models

5 June 2018

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CD59, a complement regulatory protein, controls choroidal neovascularization in a mouse model of wet-type age-related macular degeneration

5 June 2018

1 reference

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5 June 2018

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Complement activation via alternative pathway is critical in the development of laser-induced choroidal neovascularization: role of factor B and factor H.

5 June 2018

1 reference

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Drusen, choroidal neovascularization, and retinal pigment epithelium dysfunction in SOD1-deficient mice: a model of age-related macular degeneration

5 June 2018

1 reference

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Mouse models of age-related macular degeneration

5 June 2018

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Emerging roles and new functions of CD46

5 June 2018

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Apolipoprotein E allele-dependent pathogenesis: a model for age-related retinal degeneration

5 June 2018

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The retinal pigment epithelium in visual function

5 June 2018

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Lipofuscin accumulation, abnormal electrophysiology, and photoreceptor degeneration in mutant ELOVL4 transgenic mice: a model for macular degeneration

5 June 2018

1 reference

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Declines in arrestin and rhodopsin in the macula with progression of age-related macular degeneration

5 June 2018

1 reference

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Role of complement and complement membrane attack complex in laser-induced choroidal neovascularization

5 June 2018

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Prevalence of age-related macular degeneration in the United States

5 June 2018

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An animal model of age-related macular degeneration in senescent Ccl-2- or Ccr-2-deficient mice

5 June 2018

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CRB1 is essential for external limiting membrane integrity and photoreceptor morphogenesis in the mammalian retina

5 June 2018

1 reference

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A role for local inflammation in the formation of drusen in the aging eye.

5 June 2018

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Mechanisms of age-related macular degeneration.

5 June 2018

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Animal models in research on retinal degenerations: past progress and future hope

5 June 2018

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Complement activation and inflammatory processes in Drusen formation and age related macular degeneration

5 June 2018

1 reference

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Delayed dark-adaptation and lipofuscin accumulation in abcr+/- mice: implications for involvement of ABCR in age-related macular degeneration

5 June 2018

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Risk factors for age-related macular degeneration

5 June 2018

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Molecular ophthalmology: an update on animal models for retinal degenerations and dystrophies

5 June 2018

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Genetic susceptibility to age related macular degeneration

5 June 2018

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Abrogation of the alternative complement pathway by targeted deletion of murine factor B

5 June 2018

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Polyethylene glycol induced mouse model of retinal degeneration

5 June 2018

1 reference

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Bruch's membrane changes in transgenic mice overexpressing the human biglycan and apolipoprotein b-100 genes.

17 August 2018

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Properdin plays a protective role in polymicrobial septic peritonitis.

17 August 2018

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Ultrastructural changes in a murine model of graded Bruch membrane lipoidal degeneration and corresponding VEGF164 detection

17 August 2018

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SOD2 knockdown mouse model of early AMD.

17 August 2018

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VEGF expression and receptor activation in the choroid during development and in the adult.

17 August 2018

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Mouse models of ocular diseases

17 August 2018

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Basal laminar deposit formation in APO B100 transgenic mice: complex interactions between dietary fat, blue light, and vitamin E.

17 August 2018

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Risk factors for age-related macular degeneration: Pooled findings from three continents.

17 August 2018

1 reference

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Genetic disruption of the murine complement C3 promoter region generates deficient mice with extrahepatic expression of C3 mRNA.

17 August 2018

1 reference

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Uncontrolled C3 activation causes membranoproliferative glomerulonephritis in mice deficient in complement factor H

17 August 2018

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3 November 2018

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A rare nonsynonymous sequence variant in C3 is associated with high risk of age-related macular degeneration

1 December 2018

1 reference

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The R345W mutation in EFEMP1 is pathogenic and causes AMD-like deposits in mice

1 December 2018

1 reference

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Dissecting Sites Important for Complement Regulatory Activity in Membrane Cofactor Protein (MCP; CD46)

1 December 2018

1 reference

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Morphological changes of retinal pigment epithelium and choroid in rd-mice

1 December 2018

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12 December 2020

Age-related macular degeneration

1 reference

12 December 2020

Smoking mice: a potential model for studying accumulation of drusen-like material on Bruch's membrane

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12 December 2020

Induction of autophagy and cell death by tamoxifen in cultured retinal pigment epithelial and photoreceptor cells

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12 December 2020

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12 December 2020

Histologic and morphometric analysis of the choroid, Bruch's membrane, and retinal pigment epithelium in postmortem eyes with age-related macular degeneration and histologic examination of surgically excised choroidal neovascular membranes

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12 December 2020

Age-related macular degeneration

1 reference

12 December 2020

10.1016/J.AJPATH.2016.03.021

Identifiers

DOI

1 reference

15 October 2017

1 reference

15 October 2017

PubMed publication ID

27295359

1 reference