Multiple mechanisms for E2F binding inhibition by phosphorylation of the retinoblastoma protein C-terminal domain (Q42030772)

15 October 2017

Multiple mechanisms for E2F binding inhibition by phosphorylation of the retinoblastoma protein C-terminal domain (English)

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15 October 2017

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1 June 2020

Tyler J Liban

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1 June 2020

Tamara Restrepo

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1 June 2020

Hsiau-Wei Lee

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1 June 2020

Seth M Rubin

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1 June 2020

language of work or name

English

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publication date

5 October 2013

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Journal of Molecular Biology

15 October 2017

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1 June 2020

volume

426

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1 June 2020

issue

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1 June 2020

page(s)

245-255

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Molecular mechanisms underlying RB protein function

1 June 2020

cites work

1 reference

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Structural insights into the mechanism of phosphoregulation of the retinoblastoma protein

5 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3872205

Deciphering the retinoblastoma protein phosphorylation code

5 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3872205

NMR View: A computer program for the visualization and analysis of NMR data

5 June 2018

1 reference

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Structures of inactive retinoblastoma protein reveal multiple mechanisms for cell cycle control

5 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3872205

Phosphorylation-induced conformational changes in the retinoblastoma protein inhibit E2F transactivation domain binding

5 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3872205

The extreme COOH terminus of the retinoblastoma tumor suppressor protein pRb is required for phosphorylation on Thr-373 and activation of E2F.

5 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3872205

Cellular mechanisms of tumour suppression by the retinoblastoma gene.

5 June 2018

1 reference

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Structure of the Rb C-terminal domain bound to E2F1-DP1: a mechanism for phosphorylation-induced E2F release

5 June 2018

1 reference

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Cyclin C/cdk3 promotes Rb-dependent G0 exit

5 June 2018

1 reference

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pRB Contains an E2F1-Specific Binding Domain that Allows E2F1-Induced Apoptosis to Be Regulated Separately from Other E2F Activities

5 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3872205

Identification of E-box factor TFE3 as a functional partner for the E2F3 transcription factor

5 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3872205

Crystal structure of the retinoblastoma tumor suppressor protein bound to E2F and the molecular basis of its regulation

5 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3872205

Structural basis for the recognition of the E2F transactivation domain by the retinoblastoma tumor suppressor

5 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3872205

Interaction of YY1 with E2Fs, mediated by RYBP, provides a mechanism for specificity of E2F function

5 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3872205

Sibling rivalry in the E2F family

5 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3872205

Cdk phosphorylation triggers sequential intramolecular interactions that progressively block Rb functions as cells move through G1

5 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3872205

Cumulative effect of phosphorylation of pRB on regulation of E2F activity.

5 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3872205

Regulation of Rb and E2F by signal transduction cascades: divergent effects of JNK1 and p38 kinases

5 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3872205

Dual mechanisms for the inhibition of E2F binding to RB by cyclin-dependent kinase-mediated RB phosphorylation

5 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3872205

Cyclin D1/Cdk4 regulates retinoblastoma protein-mediated cell cycle arrest by site-specific phosphorylation

5 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3872205

Differential regulation of retinoblastoma protein function by specific Cdk phosphorylation sites

5 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3872205

NMRPipe: a multidimensional spectral processing system based on UNIX pipes

5 June 2018

1 reference

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Distinct sub-populations of the retinoblastoma protein show a distinct pattern of phosphorylation

5 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3872205

The retinoblastoma protein binds E2F residues required for activation in vivo and TBP binding in vitro

5 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3872205

Improved sensitivity of HSQC spectra of exchanging protons at short interscan delays using a new fast HSQC (FHSQC) detection scheme that avoids water saturation

5 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3872205

Phosphorylation of the retinoblastoma gene product is modulated during the cell cycle and cellular differentiation

5 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3872205

The retinoblastoma protein is phosphorylated during specific phases of the cell cycle

5 June 2018

1 reference

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Retinoblastoma cancer suppressor gene product is a substrate of the cell cycle regulator cdc2 kinase

5 June 2018

1 reference

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The retinoblastoma protein copurifies with E2F-I, an E1A-regulated inhibitor of the transcription factor E2F

5 June 2018

1 reference

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The E2F transcription factor is a cellular target for the RB protein

5 June 2018

1 reference

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The retinoblastoma protein is phosphorylated on multiple sites by human cdc2

5 June 2018

1 reference

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Adenovirus E1a prevents the retinoblastoma gene product from complexing with a cellular transcription factor

5 June 2018

1 reference

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Expression cloning of a cDNA encoding a retinoblastoma-binding protein with E2F-like properties

5 June 2018

1 reference

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A cDNA encoding a pRB-binding protein with properties of the transcription factor E2F

5 June 2018

1 reference

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Identification of a growth suppression domain within the retinoblastoma gene product

5 June 2018

1 reference

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Mitogen-induced rapid phosphorylation of serine 795 of the retinoblastoma gene product in vascular smooth muscle cells involves ERK activation.

5 June 2018

1 reference

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Regions controlling hyperphosphorylation and conformation of the retinoblastoma gene product are independent of domains required for transcriptional repression

17 August 2018

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12 December 2020

Differential phosphorylation of the retinoblastoma protein by G1/S cyclin-dependent kinases

1 reference

12 December 2020

The biochemical basis of CDK phosphorylation-independent regulation of E2F1 by the retinoblastoma protein

1 reference

12 December 2020

The product of the retinoblastoma susceptibility gene has properties of a cell cycle regulatory element

1 reference

12 December 2020

Defining the substrate specificity of cdk4 kinase-cyclin D1 complex

1 reference

12 December 2020

Cell cycle-dependent regulation of phosphorylation of the human retinoblastoma gene product

1 reference

12 December 2020

10.1016/J.JMB.2013.09.031

Identifiers

DOI

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1 June 2020

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1 June 2020

PubMed publication ID

24103329

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