Epigenetic inactivation of the tumor suppressor BIN1 drives proliferation of SNF5-deficient tumors. (Q42024622)

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30 January 2020

title

Epigenetic inactivation of the tumor suppressor BIN1 drives proliferation of SNF5-deficient tumors (English)

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30 January 2020

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30 January 2020

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30 January 2020

Edward C. Koellhoffer

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30 January 2020

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30 January 2020

Pablo Tamayo

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30 January 2020

Elizabeth S McKenna

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30 January 2020

Yoon-Jae Cho

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30 January 2020

E Lorena Mora-Blanco

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Scott L Pomeroy

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30 January 2020

publication date

15 May 2012

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30 January 2020

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volume

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issue

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30 January 2020

page(s)

1956-1965

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The GLI genes as the molecular switch in disrupting Hedgehog signaling in colon cancer

30 January 2020

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5 June 2018

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5 June 2018

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Loss of the epigenetic tumor suppressor SNF5 leads to cancer without genomic instability.

5 June 2018

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C-MYC overexpression is required for continuous suppression of oncogene-induced senescence in melanoma cells

5 June 2018

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RhoA-dependent regulation of cell migration by the tumor suppressor hSNF5/INI1.

5 June 2018

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5 June 2018

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Frequent BRG1/SMARCA4-inactivating mutations in human lung cancer cell lines

5 June 2018

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5 June 2018

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Methylation of the BIN1 gene promoter CpG island associated with breast and prostate cancer

5 June 2018

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5 June 2018

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The c-myc gene is a direct target of mammalian SWI/SNF-related complexes during differentiation-associated cell cycle arrest

5 June 2018

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Inactivation of the Snf5 tumor suppressor stimulates cell cycle progression and cooperates with p53 loss in oncogenic transformation.

5 June 2018

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5 June 2018

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5 June 2018

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5 June 2018

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5 June 2018

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Expression of a MYCN-interacting isoform of the tumor suppressor BIN1 is reduced in neuroblastomas with unfavorable biological features.

5 June 2018

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Molecular analysis of the rhabdoid predisposition syndrome in a child: a novel germline hSNF5/INI1 mutation and absence of c-myc amplification

5 June 2018

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Cell cycle arrest and repression of cyclin D1 transcription by INI1/hSNF5.

5 June 2018

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Disruption of Ini1 leads to peri-implantation lethality and tumorigenesis in mice

5 June 2018

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The murine SNF5/INI1 chromatin remodeling factor is essential for embryonic development and tumor suppression

5 June 2018

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Haploinsufficiency of Snf5 (integrase interactor 1) predisposes to malignant rhabdoid tumors in mice

5 June 2018

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Constitutional mutations of the hSNF5/INI1 gene predispose to a variety of cancers

5 June 2018

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Mechanism for elimination of a tumor suppressor: aberrant splicing of a brain-specific exon causes loss of function of Bin1 in melanoma.

5 June 2018

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Bin1 functionally interacts with Myc and inhibits cell proliferation via multiple mechanisms.

5 June 2018

1 reference

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c-MYC interacts with INI1/hSNF5 and requires the SWI/SNF complex for transactivation function

5 June 2018

1 reference

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Truncating mutations of hSNF5/INI1 in aggressive paediatric cancer

5 June 2018

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A new member of the amphiphysin family connecting endocytosis and signal transduction pathways

5 June 2018

1 reference

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BIN1 is a novel MYC-interacting protein with features of a tumour suppressor

5 June 2018

1 reference

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Spontaneous and carcinogen-induced tumorigenesis in p53-deficient mice.

5 June 2018

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Mice deficient for p53 are developmentally normal but susceptible to spontaneous tumours

5 June 2018

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Identification of tyrosine kinase, HCK, and tumor suppressor, BIN1, as potential mediators of AHI-1 oncogene in primary and transformed CTCL cells

5 June 2018

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Infrequent SMARCB1/INI1 gene alteration in epithelioid sarcoma: a useful tool in distinguishing epithelioid sarcoma from malignant rhabdoid tumor

17 August 2018

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Bin1 ablation increases susceptibility to cancer during aging, particularly lung cancer

17 August 2018

1 reference

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Transformation-selective apoptotic program triggered by farnesyltransferase inhibitors requires Bin1.

17 August 2018

1 reference

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Bin1 mediates apoptosis by c-Myc in transformed primary cells.

17 August 2018

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Role of the INK4a locus in tumor suppression and cell mortality.

17 August 2018

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Loss of BRG1/BRM in human lung cancer cell lines and primary lung cancers: correlation with poor prognosis

17 August 2018

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12 December 2020

Bin1 ablation in mammary gland delays tissue remodeling and drives cancer progression

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12 December 2020

Highly penetrant, rapid tumorigenesis through conditional inversion of the tumor suppressor gene Snf5

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12 December 2020

SMARCB1/INI1 protein expression in round cell soft tissue sarcomas associated with chromosomal translocations involving EWS: a special reference to SMARCB1/INI1 negative variant extraskeletal myxoid chondrosarcoma

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12 December 2020

BIN1 inhibits colony formation and induces apoptosis in neuroblastoma cell lines with MYCN amplification

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12 December 2020

Identifiers

DOI

10.4161/CC.20280

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22544318%20AND%20SRC:MED&resulttype=core&format=json

30 January 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22544318%20AND%20SRC:MED&resulttype=core&format=json

30 January 2020

PubMed publication ID

22544318

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