PD-L1 negatively regulates CD4+CD25+Foxp3+ Tregs by limiting STAT-5 phosphorylation in patients chronically infected with HCV. (Q42017650)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:19229109%20AND%20SRC:MED&resulttype=core&format=json

21 January 2020

title

PD-L1 negatively regulates CD4+CD25+Foxp3+ Tregs by limiting STAT-5 phosphorylation in patients chronically infected with HCV (English)

1 reference

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21 January 2020

1 reference

1 reference

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21 January 2020

Debora Franceschini

1 reference

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21 January 2020

Marino Paroli

1 reference

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21 January 2020

Vittorio Francavilla

1 reference

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21 January 2020

Melissa Videtta

1 reference

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21 January 2020

Stefania Morrone

1 reference

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21 January 2020

Giancarlo Labbadia

1 reference

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21 January 2020

Antonella Cerino

1 reference

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21 January 2020

Vincenzo Barnaba

1 reference

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21 January 2020

language of work or name

English

0 references

publication date

23 February 2009

1 reference

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Journal of Clinical Investigation

21 January 2020

published in

1 reference

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21 January 2020

volume

119

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21 January 2020

issue

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21 January 2020

page(s)

551-564

1 reference

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Interaction of human PD-L1 and B7-1.

21 January 2020

cites work

1 reference

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Identification and In Vitro Expansion of Functional Antigen-Specific CD25+ FoxP3+ Regulatory T Cells in Hepatitis C Virus Infection

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Enhancing therapeutic vaccination by blocking PD-1-mediated inhibitory signals during chronic infection

5 June 2018

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STAT5-signaling cytokines regulate the expression of FOXP3 in CD4+CD25+ regulatory T cells and CD4+CD25- effector T cells.

5 June 2018

1 reference

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CD4+CD25+Foxp3+ regulatory T cells induce cytokine deprivation-mediated apoptosis of effector CD4+ T cells

5 June 2018

1 reference

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Regulatory T cells and infection: a dangerous necessity

5 June 2018

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5 June 2018

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Upregulation of PD-1 Expression on Circulating and Intrahepatic Hepatitis C Virus-Specific CD8+ T Cells Associated with Reversible Immune Dysfunction

5 June 2018

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Adenosine generation catalyzed by CD39 and CD73 expressed on regulatory T cells mediates immune suppression

5 June 2018

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PD-1 and its ligands in T-cell immunity

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PD-1:PD-L1 interactions contribute to the functional suppression of virus-specific CD8+ T lymphocytes in the liver.

5 June 2018

1 reference

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The function of programmed cell death 1 and its ligands in regulating autoimmunity and infection

5 June 2018

1 reference

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Characterization of hepatitis B virus (HBV)-specific T-cell dysfunction in chronic HBV infection

5 June 2018

1 reference

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Liver-Infiltrating Lymphocytes in Chronic Human Hepatitis C Virus Infection Display an Exhausted Phenotype with High Levels of PD-1 and Low Levels of CD127 Expression

5 June 2018

1 reference

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Friendly and dangerous signals: is the tissue in control?

5 June 2018

1 reference

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Antigen presentation and the ubiquitin-proteasome system in host-pathogen interactions

5 June 2018

1 reference

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Flying under the radar: the immunobiology of hepatitis C.

5 June 2018

1 reference

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PD-1 Expression in Acute Hepatitis C Virus (HCV) Infection Is Associated with HCV-Specific CD8 Exhaustion

5 June 2018

1 reference

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PD-1 expression on HIV-specific T cells is associated with T-cell exhaustion and disease progression

5 June 2018

1 reference

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Upregulation of PD-1 expression on HIV-specific CD8+ T cells leads to reversible immune dysfunction

5 June 2018

1 reference

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CD127 expression inversely correlates with FoxP3 and suppressive function of human CD4+ T reg cells

5 June 2018

1 reference

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Single-cell analysis of normal and FOXP3-mutant human T cells: FOXP3 expression without regulatory T cell development

5 June 2018

1 reference

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5 June 2018

FOXP3: of mice and men.

1 reference

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Decreased FOXP3 levels in multiple sclerosis patients

5 June 2018

1 reference

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Coexpression of CD25 and CD27 identifies FoxP3+ regulatory T cells in inflamed synovia

5 June 2018

1 reference

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Regulation of CD4+CD25+ regulatory T cell activity: it takes (IL-)two to tango

5 June 2018

1 reference

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Mechanisms of suppression by suppressor T cells

5 June 2018

1 reference

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A well adapted regulatory contrivance: regulatory T cell development and the forkhead family transcription factor Foxp3.

5 June 2018

1 reference

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Hepatitis C reactivation in patients with chronic infection with genotypes 1b and 2c: a retrospective cohort study of 206 untreated patients

5 June 2018

1 reference

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CD25+ CD4+ T cells compete with naive CD4+ T cells for IL-2 and exploit it for the induction of IL-10 production.

5 June 2018

1 reference

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Forkhead-box transcription factors and their role in the immune system

5 June 2018

1 reference

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Functional defect of regulatory CD4(+)CD25+ T cells in the thymus of patients with autoimmune myasthenia gravis

5 June 2018

1 reference

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Tolerance, not immunity, crucially depends on IL-2.

5 June 2018

1 reference

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Interleukin-2 is essential for CD4+CD25+ regulatory T cell function

5 June 2018

1 reference

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Hepatic expansion of a virus-specific regulatory CD8(+) T cell population in chronic hepatitis C virus infection

5 June 2018

1 reference

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Naturally arising CD4+ regulatory t cells for immunologic self-tolerance and negative control of immune responses

5 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2648671

Regulation of JAK-STAT signalling in the immune system

5 June 2018

1 reference

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Immune dysregulation, polyendocrinopathy, enteropathy, and X-linked inheritance (IPEX), a syndrome of systemic autoimmunity caused by mutations of FOXP3, a critical regulator of T-cell homeostasis

5 June 2018

1 reference

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An essential role for Scurfin in CD4+CD25+ T regulatory cells

5 June 2018

1 reference

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Foxp3 programs the development and function of CD4+CD25+ regulatory T cells

5 June 2018

1 reference

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Control of regulatory T cell development by the transcription factor Foxp3

5 June 2018

1 reference

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Evasion of innate immunity by parasitic protozoa

5 June 2018

1 reference

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Interleukin 2 signaling is required for CD4(+) regulatory T cell function

5 June 2018

1 reference

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CD4+ CD25+ suppressor T cells: more questions than answers

5 June 2018

1 reference

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Cytokine signaling in 2002: new surprises in the Jak/Stat pathway

5 June 2018

1 reference

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Stimulation of CD25(+)CD4(+) regulatory T cells through GITR breaks immunological self-tolerance

5 June 2018

1 reference

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Scurfin (FOXP3) acts as a repressor of transcription and regulates T cell activation

5 June 2018

1 reference

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Hepatitis C virus infection

5 June 2018

1 reference

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Complexities of CD28/B7: CTLA-4 costimulatory pathways in autoimmunity and transplantation

5 June 2018

1 reference

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Virus-specific CD8(+) T cells with type 1 or type 2 cytokine profile are related to different disease activity in chronic hepatitis C virus infection

5 June 2018

1 reference

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Disruption of a new forkhead/winged-helix protein, scurfin, results in the fatal lymphoproliferative disorder of the scurfy mouse

5 June 2018

1 reference

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X-linked neonatal diabetes mellitus, enteropathy and endocrinopathy syndrome is the human equivalent of mouse scurfy

5 June 2018

1 reference

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Dynamics of T lymphocyte responses: intermediates, effectors, and memory cells

5 June 2018

1 reference

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Viral subversion of the immune system

5 June 2018

1 reference

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Classification of chronic hepatitis: diagnosis, grading and staging

5 June 2018

1 reference

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Immunologic self-tolerance maintained by activated T cells expressing IL-2 receptor alpha-chains (CD25). Breakdown of a single mechanism of self-tolerance causes various autoimmune diseases

5 June 2018

1 reference

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Selective expansion of cytotoxic T lymphocytes with a CD4+CD56+ surface phenotype and a T helper type 1 profile of cytokine secretion in the liver of patients chronically infected with Hepatitis B virus

5 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2648671

Recognition of hepatitis B virus envelope proteins by liver-infiltrating T lymphocytes in chronic HBV infection

5 June 2018

1 reference

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Selective killing of hepatitis B envelope antigen-specific B cells by class I-restricted, exogenous antigen-specific T lymphocytes

5 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2648671

Quantification and localisation of FOXP3+ T lymphocytes and relation to hepatic inflammation during chronic HCV infection.

5 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2648671

Dysfunction and functional restoration of HCV-specific CD8 responses in chronic hepatitis C virus infection

17 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2648671

Maintenance of the Foxp3-dependent developmental program in mature regulatory T cells requires continued expression of Foxp3.

17 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2648671

Regulated compartmentalization of programmed cell death-1 discriminates CD4+CD25+ resting regulatory T cells from activated T cells.

17 August 2018

1 reference

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Association of Foxp3 regulatory gene expression with graft-versus-host disease

17 August 2018

1 reference

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Subversion of effector CD8+ T cell differentiation in acute hepatitis C virus infection: the role of the virus.

17 August 2018

1 reference

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Subversion of effector CD8+ T cell differentiation in acute hepatitis C virus infection: exploring the immunological mechanisms

17 August 2018

1 reference

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Immunologic self-tolerance maintained by CD25+CD4+ naturally anergic and suppressive T cells: induction of autoimmune disease by breaking their anergic/suppressive state

17 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2648671

Dynamics of intra-hepatic lymphocytes in chronic hepatitis C: enrichment for Valpha24+ T cells and rapid elimination of effector cells by apoptosis.

17 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2648671

Expression and functional properties of mouse B7/BB1 using a fusion protein between mouse CTLA4 and human gamma 1.

17 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2648671

Enhanced engagement of CTLA-4 induces antigen-specific CD4+CD25+Foxp3+ and CD4+CD25- TGF-beta 1+ adaptive regulatory T cells

17 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2648671

Blockade of CTLA-4 on CD4+CD25+ regulatory T cells abrogates their function in vivo

3 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2648671

Activation requirements for the induction of CD4+CD25+ T cell suppressor function

3 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2648671

CD4+CD25high regulatory cells in human peripheral blood

3 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2648671

Foxp3-dependent programme of regulatory T-cell differentiation

3 November 2018

1 reference

12 December 2020

Regulatory T-cell functions are subverted and converted owing to attenuated Foxp3 expression

1 reference

12 December 2020

CD4 regulatory T cells prevent lethal autoimmunity in IL-2Rbeta-deficient mice. Implications for the nonredundant function of IL-2

1 reference

12 December 2020

Essential Role for STAT5 Signaling in CD25+CD4+ Regulatory T Cell Homeostasis and the Maintenance of Self-Tolerance

1 reference

12 December 2020

Enhanced production of interferon-gamma by T lymphocytes cloned from rejected kidney grafts

1 reference

12 December 2020

Identifiers

DOI

10.1172/JCI36604

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:19229109%20AND%20SRC:MED&resulttype=core&format=json

21 January 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:19229109%20AND%20SRC:MED&resulttype=core&format=json

21 January 2020

PubMed publication ID

19229109

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:19229109%20AND%20SRC:MED&resulttype=core&format=json