Adeno-associated virus-mediated delivery of a recombinant single-chain antibody against misfolded superoxide dismutase for treatment of amyotrophic lateral sclerosis (Q42003398)

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scientific article published on 17 October 2013

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English	Adeno-associated virus-mediated delivery of a recombinant single-chain antibody against misfolded superoxide dismutase for treatment of amyotrophic lateral sclerosis	scientific article published on 17 October 2013

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scholarly article

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Europe PubMed Central

PMC publication ID

15 October 2017

Adeno-associated virus-mediated delivery of a recombinant single-chain antibody against misfolded superoxide dismutase for treatment of amyotrophic lateral sclerosis (English)

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Europe PubMed Central

PMC publication ID

15 October 2017

amyotrophic lateral sclerosis

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Jean-Pierre Julien

7

object named as

Jean-Pierre Julien

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Europe PubMed Central

PMC publication ID

15 October 2017

author name string

Priyanka Patel

1

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Europe PubMed Central

PMC publication ID

15 October 2017

Jasna Kriz

2

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Europe PubMed Central

PMC publication ID

15 October 2017

Mathieu Gravel

3

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Europe PubMed Central

PMC publication ID

15 October 2017

Geneviève Soucy

4

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Europe PubMed Central

PMC publication ID

15 October 2017

Christine Bareil

5

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Europe PubMed Central

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15 October 2017

Claude Gravel

6

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15 October 2017

publication date

17 October 2013

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15 October 2017

Molecular Therapy

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15 October 2017

22

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Europe PubMed Central

PMC publication ID

15 October 2017

3

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Europe PubMed Central

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15 October 2017

498-510

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Europe PubMed Central

PMC publication ID

15 October 2017

describes a project that uses

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Europe PubMed Central

11 June 2022

https://www.ebi.ac.uk/europepmc/webservices/rest/PMC3944333/fullTextXML

based on heuristic

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Therapeutic AAV9-mediated suppression of mutant SOD1 slows disease progression and extends survival in models of inherited ALS

1 reference

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5 June 2018

Aberrant localization of FUS and TDP43 is associated with misfolding of SOD1 in amyotrophic lateral sclerosis

1 reference

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5 June 2018

An over-oxidized form of superoxide dismutase found in sporadic amyotrophic lateral sclerosis with bulbar onset shares a toxic mechanism with mutant SOD1

1 reference

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Adeno-associated virus serotype 9 transduction in the central nervous system of nonhuman primates

1 reference

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5 June 2018

Intermolecular transmission of superoxide dismutase 1 misfolding in living cells

1 reference

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Astrocytes from familial and sporadic ALS patients are toxic to motor neurons

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Wild-type and mutant SOD1 share an aberrant conformation and a common pathogenic pathway in ALS

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Novel antibodies reveal inclusions containing non-native SOD1 in sporadic ALS patients

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Superoxide dismutase 1 and tgSOD1 mouse spinal cord seed fibrils, suggesting a propagative cell death mechanism in amyotrophic lateral sclerosis

1 reference

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An ALS-linked mutant SOD1 produces a locomotor defect associated with aggregation and synaptic dysfunction when expressed in neurons of Caenorhabditis elegans

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Mutant SOD1 in cell types other than motor neurons and oligodendrocytes accelerates onset of disease in ALS mice.

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Reversal of blindness in animal models of leber congenital amaurosis using optimized AAV2-mediated gene transfer

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CNS delivery of vectored prion-specific single-chain antibodies delays disease onset

1 reference

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5 June 2018

Oxidized/misfolded superoxide dismutase-1: the cause of all amyotrophic lateral sclerosis?

1 reference

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5 June 2018

Common molecular signature in SOD1 for both sporadic and familial amyotrophic lateral sclerosis.

1 reference

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5 June 2018

Therapeutic effects of immunization with mutant superoxide dismutase in mice models of amyotrophic lateral sclerosis

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Microglia-mediated neurotoxicity: uncovering the molecular mechanisms

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Molecular biology of amyotrophic lateral sclerosis: insights from genetics

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Antisense oligonucleotide therapy for neurodegenerative disease.

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Onset and progression in inherited ALS determined by motor neurons and microglia

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5 June 2018

Innate immunity in amyotrophic lateral sclerosis.

1 reference

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5 June 2018

Chromogranin-mediated secretion of mutant superoxide dismutase proteins linked to amyotrophic lateral sclerosis

1 reference

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No widespread induction of cell death genes occurs in pure motoneurons in an amyotrophic lateral sclerosis mouse model.

1 reference

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Unraveling the mechanisms involved in motor neuron degeneration in ALS

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5 June 2018

Cross-packaging of a single adeno-associated virus (AAV) type 2 vector genome into multiple AAV serotypes enables transduction with broad specificity

1 reference

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Self-complementary recombinant adeno-associated virus (scAAV) vectors promote efficient transduction independently of DNA synthesis

1 reference

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Aggregation and Motor Neuron Toxicity of an ALS-Linked SOD1 Mutant Independent from Wild-Type SOD1

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Neurofilaments and Orthograde Transport Are Reduced in Ventral Root Axons of Transgenic Mice that Express Human SOD1 with a G93A Mutation

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ALS-linked SOD1 mutant G85R mediates damage to astrocytes and promotes rapidly progressive disease with SOD1-containing inclusions.

1 reference

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Motor neurons in Cu/Zn superoxide dismutase-deficient mice develop normally but exhibit enhanced cell death after axonal injury

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3944333

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Identification of new mutations in the Cu/Zn superoxide dismutase gene of patients with familial amyotrophic lateral sclerosis.

1 reference

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5 June 2018

Amyotrophic lateral sclerosis: Part 2. Etiopathogenesis

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Neuronal injury marker ATF-3 is induced in primary afferent neurons of monoarthritic rats

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Efficient transduction of non-human primate motor neurons after intramuscular delivery of recombinant AAV serotype 6.

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A role for motoneuron subtype-selective ER stress in disease manifestations of FALS mice

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SOD1 gene mutations in ALS patients from British Columbia, Canada: clinical features, neurophysiology and ethical issues in management

1 reference

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Wild-Type Nonneuronal Cells Extend Survival of SOD1 Mutant Motor Neurons in ALS Mice

1 reference

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17 August 2018

Self-propagation and transmission of misfolded mutant SOD1: prion or prion-like phenomenon?

1 reference

https://pubmed.ncbi.nlm.nih.gov/24394188

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based on heuristic

inferred from PubMed ID database lookup

Induction of protective immunity by vaccination with wild-type apo superoxide dismutase 1 in mutant SOD1 transgenic mice

1 reference

https://pubmed.ncbi.nlm.nih.gov/24394188

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Absence of tumor necrosis factor-alpha does not affect motor neuron disease caused by superoxide dismutase 1 mutations

1 reference

https://pubmed.ncbi.nlm.nih.gov/24394188

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based on heuristic

inferred from PubMed ID database lookup

Amyotrophic lateral sclerosis is a distal axonopathy: evidence in mice and man

1 reference

https://pubmed.ncbi.nlm.nih.gov/24394188

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based on heuristic

inferred from PubMed ID database lookup

Transgenic-mouse model of amyotrophic lateral sclerosis

1 reference

https://pubmed.ncbi.nlm.nih.gov/24394188

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Targeting of monomer/misfolded SOD1 as a therapeutic strategy for amyotrophic lateral sclerosis

1 reference

https://pubmed.ncbi.nlm.nih.gov/24394188

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based on heuristic

inferred from PubMed ID database lookup

A role for astrocytes in motor neuron loss in amyotrophic lateral sclerosis

1 reference

https://pubmed.ncbi.nlm.nih.gov/24394188

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based on heuristic

inferred from PubMed ID database lookup

Intracerebroventricular infusion of monoclonal antibody or its derived Fab fragment against misfolded forms of SOD1 mutant delays mortality in a mouse model of ALS

1 reference

https://pubmed.ncbi.nlm.nih.gov/24394188

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based on heuristic

inferred from PubMed ID database lookup

Wild-type superoxide dismutase acquires binding and toxic properties of ALS-linked mutant forms through oxidation

1 reference

https://pubmed.ncbi.nlm.nih.gov/24394188

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1038/MT.2013.239

1 reference

Europe PubMed Central

PMC publication ID

15 October 2017

PMC publication ID

1 reference

Europe PubMed Central

PMC publication ID

15 October 2017

PubMed publication ID

1 reference

Europe PubMed Central

PMC publication ID

15 October 2017

ResearchGate publication ID

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