Molecular basis for the reduced catalytic activity of the naturally occurring T560M mutant of human 12/15-lipoxygenase that has been implicated in coronary artery disease. (Q41978118)

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scientific article published on 10 May 2011

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English	Molecular basis for the reduced catalytic activity of the naturally occurring T560M mutant of human 12/15-lipoxygenase that has been implicated in coronary artery disease.	scientific article published on 10 May 2011

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31 January 2020

Molecular basis for the reduced catalytic activity of the naturally occurring T560M mutant of human 12/15-lipoxygenase that has been implicated in coronary artery disease (English)

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31 January 2020

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31 January 2020

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Hartmut Kuhn

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31 January 2020

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Kathrin Schurmann

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31 January 2020

Monika Anton

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31 January 2020

Constanze Richter

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31 January 2020

Matthias Walther

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31 January 2020

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10 May 2011

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31 January 2020

Journal of Biological Chemistry

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31 January 2020

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31 January 2020

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31 January 2020

23920-23927

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31 January 2020

The Structure of Human 5-Lipoxygenase

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5 June 2018

On the role of molecular oxygen in lipoxygenase activation: comparison and contrast of epidermal lipoxygenase-3 with soybean lipoxygenase-1.

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5 June 2018

Dioxygenase activity of epidermal lipoxygenase-3 unveiled: typical and atypical features of its catalytic activity with natural and synthetic polyunsaturated fatty acids

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Honokiol inhibits gastric tumourigenesis by activation of 15-lipoxygenase-1 and consequent inhibition of peroxisome proliferator-activated receptor-gamma and COX-2-dependent signals

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Omega-3 essential fatty acids modulate initiation and progression of neurodegenerative disease

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5 June 2018

Potential role of the lipoxygenase derived lipid mediators in atherosclerosis: leukotrienes, lipoxins and resolvins

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5 June 2018

The 5-lipoxygenase/leukotriene pathway in preclinical models of cardiovascular disease

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5 June 2018

Applicability of the triad concept for the positional specificity of mammalian lipoxygenases

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5 June 2018

Treating inflammation in atherosclerotic cardiovascular disease: emerging therapies

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5 June 2018

Lipoxygenases - Structure and reaction mechanism.

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5 June 2018

New aspects of the role of hydroxyeicosatetraenoic acids in cell growth and cancer development

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Lipid signalling in disease.

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5 June 2018

A near null variant of 12/15-LOX encoded by a novel SNP in ALOX15 and the risk of coronary artery disease

1 reference

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5 June 2018

The two faces of the 15-lipoxygenase in atherosclerosis

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5 June 2018

Conformational flexibility in mammalian 15S-lipoxygenase: Reinterpretation of the crystallographic data

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5 June 2018

Inflammation and immune regulation by 12/15-lipoxygenases

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5 June 2018

Lipoxygenase pathways in atherogenesis

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5 June 2018

Expanding expression of the 5-lipoxygenase pathway within the arterial wall during human atherogenesis

1 reference

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5 June 2018

The N-terminal domain of the reticulocyte-type 15-lipoxygenase is not essential for enzymatic activity but contains determinants for membrane binding

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5 June 2018

Lipoxygenases: occurrence, functions, catalysis, and acquisition of substrate

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5 June 2018

The structure of mammalian 15-lipoxygenase reveals similarity to the lipases and the determinants of substrate specificity

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5 June 2018

In vivo action of 15-lipoxygenase in early stages of human atherogenesis

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5 June 2018

VMD: visual molecular dynamics

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5 June 2018

Kinetic analysis of the induction period in lipoxygenase catalysis.

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5 June 2018

Identification of a specific methionine in mammalian 15-lipoxygenase which is oxygenated by the enzyme product 13-HPODE: dissociation of sulfoxide formation from self-inactivation

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5 June 2018

A primary determinant for lipoxygenase positional specificity

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5 June 2018

Colocalization of 15-lipoxygenase mRNA and protein with epitopes of oxidized low density lipoprotein in macrophage-rich areas of atherosclerotic lesions

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5 June 2018

Effect of lipid hydroperoxide on lipoxygenase kinetics.

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5 June 2018

The Lipoxygenase of Reticulocytes. Purification, Characterization and Biological Dynamics of the Lipoxygenase; Its Identity with the Respiratory Inhibitors of the Reticulocyte

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5 June 2018

No association of two functional polymorphisms in human ALOX15 with myocardial infarction

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18 August 2018

Protective effects of nimesulide (COX Inhibitor), AKBA (5-LOX Inhibitor), and their combination in aging-associated abnormalities in mice

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Dual role of oxygen during lipoxygenase reactions

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18 August 2018

Shape and specificity in mammalian 15-lipoxygenase active site. The functional interplay of sequence determinants for the reaction specificity.

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Methionine sulfoxide formation: the cause of self-inactivation of reticulocyte lipoxygenase

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12 December 2020

based on heuristic

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The inflammation paradigm in cardiovascular disease

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https://pubmed.ncbi.nlm.nih.gov/21558275

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Lipoxygenase pathways as mediators of early inflammatory events in atherosclerosis

1 reference

https://pubmed.ncbi.nlm.nih.gov/21558275

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

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10.1074/JBC.M110.211821

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31 January 2020

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31 January 2020

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31 January 2020

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