MICU1 controls both the threshold and cooperative activation of the mitochondrial Ca²⁺ uniporter (Q41976396)

14 October 2017

MICU1 controls both the threshold and cooperative activation of the mitochondrial Ca²⁺ uniporter (English)

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14 October 2017

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14 October 2017

Victor E. Koteliansky

object named as

Victor Koteliansky

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14 October 2017

Roman Bogorad

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14 October 2017

Yasemin Sancak

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14 October 2017

Vamsi K Mootha

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14 October 2017

Fabiana Perocchi

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14 October 2017

György Csordás

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14 October 2017

Tünde Golenár

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14 October 2017

Erin L Seifert

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14 October 2017

Cynthia Moffat

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14 October 2017

David Weaver

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14 October 2017

Sergio de la Fuente Perez

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14 October 2017

Jeffrey Adijanto

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14 October 2017

György Hajnóczky

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14 October 2017

language of work or name

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1 June 2013

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14 October 2017

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14 October 2017

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14 October 2017

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14 October 2017

976-987

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MICU2, a paralog of MICU1, resides within the mitochondrial uniporter complex to regulate calcium handling

14 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3722067

MCUR1 is an essential component of mitochondrial Ca2+ uptake that regulates cellular metabolism

5 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3722067

MICU1 is an essential gatekeeper for MCU-mediated mitochondrial Ca(2+) uptake that regulates cell survival

5 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3722067

Evolutionary diversity of the mitochondrial calcium uniporter

5 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3722067

A forty-kilodalton protein of the inner membrane is the mitochondrial calcium uniporter

5 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3722067

Integrative genomics identifies MCU as an essential component of the mitochondrial calcium uniporter

5 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3722067

Dynamic regulation of the mitochondrial proton gradient during cytosolic calcium elevations

5 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3722067

MICU1 encodes a mitochondrial EF hand protein required for Ca(2+) uptake

5 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3722067

Imaging interorganelle contacts and local calcium dynamics at the ER-mitochondrial interface

5 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3722067

Ca2+ hot spots on the mitochondrial surface are generated by Ca2+ mobilization from stores, but not by activation of store-operated Ca2+ channels.

5 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3722067

Genome-wide RNAi screen identifies Letm1 as a mitochondrial Ca2+/H+ antiporter

5 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3722067

Mitofusin 2 tethers endoplasmic reticulum to mitochondria

5 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3722067

Control of K(Ca) channels by calcium nano/microdomains

5 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3722067

High- and low-calcium-dependent mechanisms of mitochondrial calcium signalling

5 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3722067

Uncoupling proteins 2 and 3 are fundamental for mitochondrial Ca2+ uniport

5 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3722067

Chaperone-mediated coupling of endoplasmic reticulum and mitochondrial Ca2+ channels.

5 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3722067

Structural and functional features and significance of the physical linkage between ER and mitochondria.

5 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3722067

Structural and functional relationships between Ca2+ puffs and mitochondria in Xenopus oocytes

5 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3722067

Ca2+ marks: miniature calcium signals in single mitochondria driven by ryanodine receptors

5 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3722067

Propagation of the apoptotic signal by mitochondrial waves

5 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3722067

The Ca2+ concentration of the endoplasmic reticulum is a key determinant of ceramide-induced apoptosis: significance for the molecular mechanism of Bcl-2 action

5 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3722067

Regulation of mitochondrial ATP synthesis by calcium: evidence for a long-term metabolic priming

5 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3722067

Apoptosis driven by IP(3)-linked mitochondrial calcium signals

5 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3722067

Active mitochondria surrounding the pancreatic acinar granule region prevent spreading of inositol trisphosphate-evoked local cytosolic Ca(2+) signals.

5 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3722067

Quasi-synaptic calcium signal transmission between endoplasmic reticulum and mitochondria

5 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3722067

Integrating cytosolic calcium signals into mitochondrial metabolic responses

5 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3722067

Close contacts with the endoplasmic reticulum as determinants of mitochondrial Ca2+ responses

5 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3722067

A role for calcium influx in the regulation of mitochondrial calcium in endothelial cells

5 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3722067

Mitochondrial calcium transport: physiological and pathological relevance

5 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3722067

Mitochondrial Ca2+ homeostasis in intact cells

5 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3722067

Synchronization of calcium waves by mitochondrial substrates in Xenopus laevis oocytes.

5 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3722067

Mechanisms by which mitochondria transport calcium

5 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3722067

Kinetics of calcium(2+) ion carrier in rat liver mitochondria

5 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3722067

Mammalian Oxa1 protein is useful for assessment of submitochondrial protein localization and mitochondrial membrane integrity.

5 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3722067

Type 1 ryanodine receptor in cardiac mitochondria: transducer of excitation-metabolism coupling

18 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3722067

The mitochondrial calcium uniporter is a highly selective ion channel.

18 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3722067

Plasticity of mitochondrial calcium signaling

18 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3722067

The relationship between free and total calcium concentrations in the matrix of liver and brain mitochondria.

18 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3722067

EGTA inhibits reverse uniport-dependent Ca2+ release from uncoupled mitochondria. Possible regulation of the Ca2+ uniporter by a Ca2+ binding site on the cytoplasmic side of the inner membrane

18 August 2018

1 reference

12 December 2020

"Allosteric regulation" of calcium-uptake in rat liver mitochondria

1 reference

12 December 2020

Tissue-specific modulation of the mitochondrial calcium uniporter by magnesium ions

1 reference

12 December 2020

Mitochondrial calcium uptake from physiological-type pulses of calcium. A description of the rapid uptake mode

1 reference

12 December 2020

Decoding of cytosolic calcium oscillations in the mitochondria

1 reference

12 December 2020

Dynamic pacing of cell metabolism by intracellular Ca2+ transients

1 reference

12 December 2020

Microdomains with high Ca2+ close to IP3-sensitive channels that are sensed by neighboring mitochondria

1 reference

12 December 2020

Mitochondria suppress local feedback activation of inositol 1,4, 5-trisphosphate receptors by Ca2+

1 reference

12 December 2020

Assaying protein import into mitochondria

1 reference

12 December 2020

Genetically encoded fluorescent indicator for intracellular hydrogen peroxide

1 reference

12 December 2020

10.1016/J.CMET.2013.04.020

Identifiers

DOI

1 reference

14 October 2017

1 reference

14 October 2017

PubMed publication ID

23747253

1 reference