The radical trap 5,5-dimethyl-1-pyrroline N-oxide exerts dose-dependent protection against myocardial ischemia-reperfusion injury through preservation of mitochondrial electron transport (Q41953172)

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scientific article published on 6 February 2009

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English	The radical trap 5,5-dimethyl-1-pyrroline N-oxide exerts dose-dependent protection against myocardial ischemia-reperfusion injury through preservation of mitochondrial electron transport	scientific article published on 6 February 2009

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scholarly article

1 reference

Europe PubMed Central

PMC publication ID

14 October 2017

The radical trap 5,5-dimethyl-1-pyrroline N-oxide exerts dose-dependent protection against myocardial ischemia-reperfusion injury through preservation of mitochondrial electron transport (English)

1 reference

Europe PubMed Central

PMC publication ID

14 October 2017

reperfusion injury

1 reference

based on heuristic

inferred from title

author name string

Li Zuo

1

1 reference

Europe PubMed Central

PMC publication ID

14 October 2017

Yeong-Renn Chen

2

1 reference

Europe PubMed Central

PMC publication ID

14 October 2017

Levy A Reyes

3

1 reference

Europe PubMed Central

PMC publication ID

14 October 2017

Hsin-Ling Lee

4

1 reference

Europe PubMed Central

PMC publication ID

14 October 2017

Chwen-Lih Chen

5

1 reference

Europe PubMed Central

PMC publication ID

14 October 2017

Frederick A Villamena

6

1 reference

Europe PubMed Central

PMC publication ID

14 October 2017

Jay L Zweier

7

1 reference

Europe PubMed Central

PMC publication ID

14 October 2017

language of work or name

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publication date

6 February 2009

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Europe PubMed Central

PMC publication ID

14 October 2017

Journal of Pharmacology and Experimental Therapeutics

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Europe PubMed Central

PMC publication ID

14 October 2017

329

1 reference

Europe PubMed Central

PMC publication ID

14 October 2017

2

1 reference

Europe PubMed Central

PMC publication ID

14 October 2017

515-523

1 reference

Europe PubMed Central

PMC publication ID

14 October 2017

Endothelial cell respiration is affected by the oxygen tension during shear exposure: role of mitochondrial peroxynitrite

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2672876

5 June 2018

Myocardial ischemia results in tetrahydrobiopterin (BH4) oxidation with impaired endothelial function ameliorated by BH4.

1 reference

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5 June 2018

Detection, characterization, and decay kinetics of ROS and thiyl adducts of mito-DEPMPO spin trap

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2672876

5 June 2018

The role of oxidants and free radicals in reperfusion injury

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2672876

5 June 2018

The mitochondrial biogenesis regulatory program in cardiac adaptation to ischemia--a putative target for therapeutic intervention

1 reference

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5 June 2018

Neuroprotection in ischemia: blocking calcium-permeable acid-sensing ion channels.

1 reference

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5 June 2018

Detection of reactive oxygen and nitrogen species by EPR spin trapping

1 reference

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5 June 2018

Mitochondrial biogenesis in mammals: the role of endogenous nitric oxide.

1 reference

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5 June 2018

Detection of reactive oxygen and nitrogen species in tissues using redox-sensitive fluorescent probes

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2672876

5 June 2018

Cardioprotective function of inducible nitric oxide synthase and role of nitric oxide in myocardial ischemia and preconditioning: an overview of a decade of research

1 reference

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5 June 2018

Intra- and extracellular measurement of reactive oxygen species produced during heat stress in diaphragm muscle

1 reference

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5 June 2018

Nitrone inhibition of age-associated oxidative damage

1 reference

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5 June 2018

Nature of the inhibition of horseradish peroxidase and mitochondrial cytochrome c oxidase by cyanyl radical

1 reference

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5 June 2018

Expression of a renal type I sodium/phosphate transporter (NaPi-1) induces a conductance in Xenopus oocytes permeable for organic and inorganic anions

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2672876

5 June 2018

Nitrone spin-traps block calcium channels and induce pulmonary artery relaxation independent of free radicals.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2672876

5 June 2018

Direct measurement of free radical generation following reperfusion of ischemic myocardium

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2672876

5 June 2018

Marked reduction of free radical generation and contractile dysfunction by antioxidant therapy begun at the time of reperfusion. Evidence that myocardial "stunning" is a manifestation of reperfusion injury

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2672876

5 June 2018

Reperfusion-induced arrhythmias and free radicals: studies in the rat heart with DMPO.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2672876

5 June 2018

DMPO and reperfusion injury: arrhythmia, heart function, electron spin resonance, and nuclear magnetic resonance studies in isolated working guinea pig hearts

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2672876

5 June 2018

Heart protection and radical trapping by DMPO during reperfusion in isolated working rat hearts

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2672876

5 June 2018

Global ischaemia induces a biphasic response of the mitochondrial respiratory chain. Anoxic pre-perfusion protects against ischaemic damage

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2672876

5 June 2018

Mitochondrial complex II in the post-ischemic heart: oxidative injury and the role of protein S-glutathionylation.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2672876

18 August 2018

Direct and indirect roles of cytochrome b in the mediation of superoxide generation and NO catabolism by mitochondrial succinate-cytochrome c reductase

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2672876

18 August 2018

Reactive oxygen species generated by the mitochondrial respiratory chain affect the complex III activity via cardiolipin peroxidation in beef-heart submitochondrial particles

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2672876

18 August 2018

Nitric oxide release from the unimolecular decomposition of the superoxide radical anion adduct of cyclic nitrones in aqueous medium

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2672876

18 August 2018

Selective inactivation of redox-sensitive mitochondrial enzymes during cardiac reperfusion

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2672876

18 August 2018

Theoretical and experimental studies of the spin trapping of inorganic radicals by 5,5-dimethyl-1-pyrroline N-oxide (DMPO). 2. Carbonate radical anion

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2672876

3 November 2018

Nitrone spin traps and their pyrrolidine analogs in myocardial reperfusion injury: hemodynamic and ESR implications--evidence for a cardioprotective phosphonate effect for 5-(diethoxyphosphoryl)-5-methyl-1-pyrroline N-oxide in rat hearts

1 reference

https://pubmed.ncbi.nlm.nih.gov/19201989

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Measurement and characterization of postischemic free radical generation in the isolated perfused heart

1 reference

https://pubmed.ncbi.nlm.nih.gov/19201989

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Superoxide radical anion adduct of 5,5-dimethyl-1-pyrroline N-oxide (DMPO). 3. Effect of mildly acidic pH on the thermodynamics and kinetics of adduct formation

1 reference

https://pubmed.ncbi.nlm.nih.gov/19201989

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Does the antiarrhythmic effect of DMPO originate from its oxygen radical trapping property or the structure of the molecule itself?

1 reference

https://pubmed.ncbi.nlm.nih.gov/19201989

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Targeting an antioxidant to mitochondria decreases cardiac ischemia-reperfusion injury

1 reference

https://pubmed.ncbi.nlm.nih.gov/19201989

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Is reduced SERCA2a expression detrimental or beneficial to postischemic cardiac function and injury? Evidence from heterozygous SERCA2a knockout mice

1 reference

https://pubmed.ncbi.nlm.nih.gov/19201989

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Measurement of superoxide-derived free radicals in the reperfused heart. Evidence for a free radical mechanism of reperfusion injury

1 reference

https://pubmed.ncbi.nlm.nih.gov/19201989

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

New perspectives on the cardioprotective phosphonate effect of the spin trap 5-(diethoxyphosphoryl)-5-methyl-1-pyrroline N-oxide: an hemodynamic and 31P NMR study in rat hearts

1 reference

https://pubmed.ncbi.nlm.nih.gov/19201989

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The cardiac adrenergic system in ischaemia: differential role of acidosis and energy depletion

1 reference

https://pubmed.ncbi.nlm.nih.gov/19201989

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Vasodilatory and toxic effects of spin traps on aerobic cardiac function

1 reference

https://pubmed.ncbi.nlm.nih.gov/19201989

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Formation of reactive oxygen species by the contracting diaphragm is PLA(2) dependent

1 reference

https://pubmed.ncbi.nlm.nih.gov/19201989

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Evidence that mitochondrial respiration is a source of potentially toxic oxygen free radicals in intact rabbit hearts subjected to ischemia and reflow

1 reference

https://pubmed.ncbi.nlm.nih.gov/19201989

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The hydrophilic spin trap, 5,5-dimethyl-1-pyrroline-1-oxide, does not protect the rat heart from reperfusion injury

1 reference

https://pubmed.ncbi.nlm.nih.gov/19201989

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Measurement of nitric oxide and peroxynitrite generation in the postischemic heart. Evidence for peroxynitrite-mediated reperfusion injury

1 reference

https://pubmed.ncbi.nlm.nih.gov/19201989

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1124/JPET.108.143479

1 reference

Europe PubMed Central

PMC publication ID

14 October 2017

PMC publication ID

1 reference

Europe PubMed Central

PMC publication ID

14 October 2017

PubMed publication ID

1 reference

Europe PubMed Central

PMC publication ID

14 October 2017

ResearchGate publication ID

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