Inactivation of mTORC1 in the developing brain causes microcephaly and affects gliogenesis. (Q41932134)

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29 February 2020

title

Inactivation of mTORC1 in the developing brain causes microcephaly and affects gliogenesis (English)

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29 February 2020

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Suzana Atanasoski

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29 February 2020

Constanze Baranek

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29 February 2020

Dimitri Cloëtta

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29 February 2020

Venus Thomanetz

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29 February 2020

Regula M Lustenberger

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29 February 2020

Shuo Lin

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29 February 2020

Filippo Oliveri

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29 February 2020

Markus A Rüegg

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29 February 2020

language of work or name

English

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publication date

1 May 2013

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29 February 2020

published in

Journal of Neuroscience

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29 February 2020

volume

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issue

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29 February 2020

page(s)

7799-7810

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The flat-top gene is required for the expansion and regionalization of the telencephalic primordium

29 February 2020

cites work

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12 December 2020

Cellular and molecular guidance of GABAergic neuronal migration from an extracortical origin to the neocortex

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Disruption of the glucocorticoid receptor gene in the nervous system results in reduced anxiety

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Drosophila S6 kinase: a regulator of cell size

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Serine phosphorylation and maximal activation of STAT3 during CNTF signaling is mediated by the rapamycin target mTOR

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Genetic and biochemical characterization of dTOR, the Drosophila homolog of the target of rapamycin

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Characterization of CNS precursor subtypes and radial glia

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Beta1-class integrins regulate the development of laminae and folia in the cerebral and cerebellar cortex

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FRAP/mTOR is required for proliferation and patterning during embryonic development in the mouse

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Chemotropic responses of retinal growth cones mediated by rapid local protein synthesis and degradation

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TOR deficiency in C. elegans causes developmental arrest and intestinal atrophy by inhibition of mRNA translation

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Tsc2 null murine neuroepithelial cells are a model for human tuber giant cells, and show activation of an mTOR pathway

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BMPs signal alternately through a SMAD or FRAP-STAT pathway to regulate fate choice in CNS stem cells

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Development of midline glial populations at the corticoseptal boundary.

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Target of rapamycin (TOR): an integrator of nutrient and growth factor signals and coordinator of cell growth and cell cycle progression

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mTOR is essential for growth and proliferation in early mouse embryos and embryonic stem cells

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12 December 2020

Rictor, a novel binding partner of mTOR, defines a rapamycin-insensitive and raptor-independent pathway that regulates the cytoskeleton

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12 December 2020

Mammalian TOR complex 2 controls the actin cytoskeleton and is rapamycin insensitive

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12 December 2020

Disruption of the mouse mTOR gene leads to early postimplantation lethality and prohibits embryonic stem cell development

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12 December 2020

Axonal protein synthesis and degradation are necessary for efficient growth cone regeneration

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12 December 2020

Role for Akt3/protein kinase Bgamma in attainment of normal brain size

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Phosphorylation and regulation of Akt/PKB by the rictor-mTOR complex

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A positive autoregulatory loop of Jak-STAT signaling controls the onset of astrogliogenesis

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12 December 2020

Foxg1 is required for specification of ventral telencephalon and region-specific regulation of dorsal telencephalic precursor proliferation and apoptosis

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12 December 2020

Essential role of protein kinase B gamma (PKB gamma/Akt3) in postnatal brain development but not in glucose homeostasis

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12 December 2020

The cell biology of neurogenesis

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12 December 2020

Regulation of dendritic morphogenesis by Ras-PI3K-Akt-mTOR and Ras-MAPK signaling pathways.

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12 December 2020

Control of dendritic arborization by the phosphoinositide-3'-kinase-Akt-mammalian target of rapamycin pathway.

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12 December 2020

TOR signaling in growth and metabolism

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12 December 2020

Ablation in mice of the mTORC components raptor, rictor, or mLST8 reveals that mTORC2 is required for signaling to Akt-FOXO and PKCalpha, but not S6K1

1 reference

12 December 2020

Chondroitin sulfate glycosaminoglycans control proliferation, radial glia cell differentiation and neurogenesis in neural stem/progenitor cells

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12 December 2020

Role of mTOR in physiology and pathology of the nervous system

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12 December 2020

Nogo-66 promotes the differentiation of neural progenitors into astroglial lineage cells through mTOR-STAT3 pathway

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12 December 2020

Mammalian target of rapamycin (mTOR) is involved in the neuronal differentiation of neural progenitors induced by insulin

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12 December 2020

Rheb and mTOR regulate neuronal polarity through Rap1B

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12 December 2020

Promoting axon regeneration in the adult CNS by modulation of the PTEN/mTOR pathway

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12 December 2020

Adipose-specific knockout of raptor results in lean mice with enhanced mitochondrial respiration

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12 December 2020

Skeletal muscle-specific ablation of raptor, but not of rictor, causes metabolic changes and results in muscle dystrophy

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12 December 2020

Isolation and manipulation of mammalian neural stem cells in vitro

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12 December 2020

TORC-specific phosphorylation of mammalian target of rapamycin (mTOR): phospho-Ser2481 is a marker for intact mTOR signaling complex 2.

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12 December 2020

beta1 integrin maintains integrity of the embryonic neocortical stem cell niche

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12 December 2020

Sip1 regulates sequential fate decisions by feedback signaling from postmitotic neurons to progenitors

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12 December 2020

Mitotic raptor promotes mTORC1 activity, G(2)/M cell cycle progression, and internal ribosome entry site-mediated mRNA translation

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12 December 2020

mTORC1-mediated cell proliferation, but not cell growth, controlled by the 4E-BPs

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12 December 2020

Rheb1 is required for mTORC1 and myelination in postnatal brain development

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12 December 2020

Cardiac raptor ablation impairs adaptive hypertrophy, alters metabolic gene expression, and causes heart failure in mice.

1 reference

12 December 2020

mTOR kinase domain phosphorylation promotes mTORC1 signaling, cell growth, and cell cycle progression

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12 December 2020

Protooncogene Ski cooperates with the chromatin-remodeling factor Satb2 in specifying callosal neurons.

1 reference

12 December 2020

mTOR signaling in growth control and disease

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12 December 2020

Shaping our minds: stem and progenitor cell diversity in the mammalian neocortex

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12 December 2020

A simple, rapid, and sensitive DNA assay procedure

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12 December 2020

Maximal activation of transcription by Stat1 and Stat3 requires both tyrosine and serine phosphorylation

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12 December 2020

Independent regulatory elements in the nestin gene direct transgene expression to neural stem cells or muscle precursors

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12 December 2020

Developmental pattern of GFAP and vimentin gene expression in rat brain and in radial glial cultures.

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12 December 2020

Clonal and population analyses demonstrate that an EGF-responsive mammalian embryonic CNS precursor is a stem cell

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12 December 2020

Single factors direct the differentiation of stem cells from the fetal and adult central nervous system.

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12 December 2020

Regulation of Gliogenesis in the Central Nervous System by the JAK-STAT Signaling Pathway

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12 December 2020

Disruption of the p70(s6k)/p85(s6k) gene reveals a small mouse phenotype and a new functional S6 kinase

1 reference

12 December 2020

10.1523/JNEUROSCI.3294-12.2013

Identifiers

DOI

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29 February 2020

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29 February 2020

PubMed publication ID

23637172

1 reference

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