Thymineless death in F10-treated AML cells occurs via lipid raft depletion and Fas/FasL co-localization in the plasma membrane with activation of the extrinsic apoptotic pathway (Q41871248)

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scientific article published on 29 November 2014

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English	Thymineless death in F10-treated AML cells occurs via lipid raft depletion and Fas/FasL co-localization in the plasma membrane with activation of the extrinsic apoptotic pathway	scientific article published on 29 November 2014

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scholarly article

1 reference

Europe PubMed Central

PMC publication ID

13 October 2017

Thymineless death in F10-treated AML cells occurs via lipid raft depletion and Fas/FasL co-localization in the plasma membrane with activation of the extrinsic apoptotic pathway (English)

1 reference

Europe PubMed Central

PMC publication ID

13 October 2017

apoptotic process

0 references

1 reference

based on heuristic

inferred from title

Timothy S Pardee

4

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25510486%20AND%20SRC:MED&resulttype=core&format=json

11 June 2020

author name string

William H Gmeiner

1

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Europe PubMed Central

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25510486%20AND%20SRC:MED&resulttype=core&format=json

11 June 2020

Jamie Jennings-Gee

2

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25510486%20AND%20SRC:MED&resulttype=core&format=json

11 June 2020

Christopher H Stuart

3

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Europe PubMed Central

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11 June 2020

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inferred from title

publication date

29 November 2014

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13 October 2017

Leukemia Research

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25510486%20AND%20SRC:MED&resulttype=core&format=json

11 June 2020

39

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11 June 2020

2

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25510486%20AND%20SRC:MED&resulttype=core&format=json

11 June 2020

229-235

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25510486%20AND%20SRC:MED&resulttype=core&format=json

11 June 2020

The poison oligonucleotide F10 is highly effective against acute lymphoblastic leukemia while sparing normal hematopoietic cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4306618

5 June 2018

Lipid raft-mediated Akt signaling as a therapeutic target in mantle cell lymphoma

1 reference

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NK4 regulates 5-fluorouracil sensitivity in cholangiocarcinoma cells by modulating the intrinsic apoptosis pathway

1 reference

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5 June 2018

Replication-dependent irreversible topoisomerase 1 poisoning is responsible for FdUMP[10] anti-leukemic activity

1 reference

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CD44 ligation with A3D8 antibody induces apoptosis in acute myeloid leukemia cells through binding to CD44s and clustering lipid rafts

1 reference

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5 June 2018

Unique dual targeting of thymidylate synthase and topoisomerase1 by FdUMP[10] results in high efficacy against AML and low toxicity

1 reference

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FGFR signaling promotes the growth of triple-negative and basal-like breast cancer cell lines both in vitro and in vivo

1 reference

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Poly(ADP-ribose) polymerase and XPF–ERCC1 participate in distinct pathways for the repair of topoisomerase I-induced DNA damage in mammalian cells

1 reference

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Effect of simvastatin on glioma cell proliferation, migration, and apoptosis

1 reference

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5 June 2018

Involvement of raft aggregates enriched in Fas/CD95 death-inducing signaling complex in the antileukemic action of edelfosine in Jurkat cells

1 reference

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5 June 2018

Inhibition of poly(ADP-ribose) polymerase-1 enhances temozolomide and topotecan activity against childhood neuroblastoma.

1 reference

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5 June 2018

A ubiquitin-proteasome pathway for the repair of topoisomerase I-DNA covalent complexes.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4306618

5 June 2018

Fas/CD95 death receptor and lipid rafts: new targets for apoptosis-directed cancer therapy.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4306618

5 June 2018

Elevated levels of cholesterol-rich lipid rafts in cancer cells are correlated with apoptosis sensitivity induced by cholesterol-depleting agents

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4306618

5 June 2018

Nuclear factor-kappaB mediates Kupffer cell apoptosis through transcriptional activation of Fas/FasL

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4306618

5 June 2018

Novel chemical strategies for thymidylate synthase inhibition

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4306618

5 June 2018

CD95 death-inducing signaling complex formation and internalization occur in lipid rafts of type I and type II cells.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4306618

5 June 2018

Enhanced DNA-directed effects of FdUMP[10] compared to 5FU.

1 reference

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5 June 2018

Activation of Fas by FasL induces apoptosis by a mechanism that cannot be blocked by Bcl-2 or Bcl-x(L)

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4306618

5 June 2018

Differential modulation of apoptosis sensitivity in CD95 type I and type II cells.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4306618

5 June 2018

A Fas-dependent component in 5-fluorouracil/leucovorin-induced cytotoxicity in colon carcinoma cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4306618

5 June 2018

DNA damaging agents induce expression of Fas ligand and subsequent apoptosis in T lymphocytes via the activation of NF-kappa B and AP-1.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4306618

5 June 2018

Thymineless death in colon carcinoma cells is mediated via Fas signaling

1 reference

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Quantitative analysis of dose-effect relationships: the combined effects of multiple drugs or enzyme inhibitors

1 reference

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Time dependence of DNA lesions and growth inhibition by ICI D1694, a new quinazoline antifolate thymidylate synthase inhibitor

1 reference

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5 June 2018

A novel polypyrimidine antitumor agent FdUMP[10] induces thymineless death with topoisomerase I-DNA complexes

1 reference

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18 August 2018

Regulation of FasL by NF-κB and AP-1 in Fas-dependent Thymineless Death of Human Colon Carcinoma Cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/25510486

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Fluorodeoxyuridine-mediated cytotoxicity and radiosensitization require S phase progression

1 reference

https://pubmed.ncbi.nlm.nih.gov/25510486

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1016/J.LEUKRES.2014.11.006

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25510486%20AND%20SRC:MED&resulttype=core&format=json

11 June 2020

PMC publication ID

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25510486%20AND%20SRC:MED&resulttype=core&format=json

11 June 2020

PubMed publication ID

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25510486%20AND%20SRC:MED&resulttype=core&format=json

11 June 2020

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