Expression and characterization of a recombinant cysteine proteinase of Leishmania mexicana. (Q41832493)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:10749667%20AND%20SRC:MED&resulttype=core&format=json

5 November 2019

title

Expression and characterization of a recombinant cysteine proteinase of Leishmania mexicana (English)

1 reference

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5 November 2019

Leishmania mexicana

1 reference

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5 November 2019

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5 November 2019

S J Sanderson

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5 November 2019

K G Pollock

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5 November 2019

J D Hilley

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5 November 2019

P S Hilaire

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5 November 2019

M A Juliano

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5 November 2019

L Juliano

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5 November 2019

G H Coombs

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5 November 2019

language of work or name

English

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publication date

1 April 2000

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5 November 2019

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5 November 2019

volume

347

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5 November 2019

issue

Pt 2

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5 November 2019

page(s)

383-388

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Cysteine protease inhibitors as chemotherapy: lessons from a parasite target

5 November 2019

cites work

1 reference

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Protease trafficking in two primitive eukaryotes is mediated by a prodomain protein motif

6 June 2018

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Roles of cysteine proteinases of trypanosomes and Leishmania in host-parasite interactions.

6 June 2018

1 reference

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Inhibition of trypanosomal cysteine proteinases by their propeptides.

6 June 2018

1 reference

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Cysteine protease inhibitors cure an experimental Trypanosoma cruzi infection

6 June 2018

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Proregion structure of members of the papain superfamily. Mode of inhibition of enzymatic activity

6 June 2018

1 reference

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Autocatalytic processing of recombinant human procathepsin L. Contribution of both intermolecular and unimolecular events in the processing of procathepsin L in vitro

6 June 2018

1 reference

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Parasite proteinases and amino acid metabolism: possibilities for chemotherapeutic exploitation.

6 June 2018

1 reference

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Structure of human procathepsin L reveals the molecular basis of inhibition by the prosegment

6 June 2018

1 reference

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Structure of rat procathepsin B: model for inhibition of cysteine protease activity by the proregion

6 June 2018

1 reference

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Evidence from disruption of the lmcpb gene array of Leishmania mexicana that cysteine proteinases are virulence factors.

6 June 2018

1 reference

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The lysosomal proenzyme receptor that binds procathepsin L to microsomal membranes at pH 5 is a 43-kDa integral membrane protein

6 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1220970

The proregion of cathepsin L is required for proper folding, stability, and ER exit

6 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1220970

Multiple high activity cysteine proteases of Leishmania mexicana are encoded by the Imcpb gene array

6 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1220970

Refolding recombinant proteins: process strategies and novel approaches

6 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1220970

The preparation of catalytically active human cathepsin B from its precursor expressed in Escherichia coli in the form of inclusion bodies.

6 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1220970

Antigen presentation by Leishmania mexicana-infected macrophages: activation of helper T cells specific for amastigote cysteine proteinases requires intracellular killing of the parasites.

6 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1220970

L-trans-Epoxysuccinyl-leucylamido(4-guanidino)butane (E-64) and its analogues as inhibitors of cysteine proteinases including cathepsins B, H and L

6 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1220970

Cleavage of Structural Proteins during the Assembly of the Head of Bacteriophage T4

6 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1220970

Sequence from picomole quantities of proteins electroblotted onto polyvinylidene difluoride membranes

6 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1220970

Isolation and sequence of a cDNA for human pro-(cathepsin L)

6 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1220970

A cysteine proteinase cDNA from Trypanosoma brucei predicts an enzyme with an unusual C-terminal extension

6 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1220970

Characterisation of three groups of cysteine proteinases in the amastigotes of Leishmania mexicana mexicana

6 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1220970

Expression of the collagenolytic and Ras-induced cysteine proteinase cathepsin L and proliferation-associated oncogenes in synovial cells of MRL/I mice and patients with rheumatoid arthritis.

6 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1220970

Expression and deletion analysis of the Trypanosoma brucei rhodesiense cysteine protease in Escherichia coli

6 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1220970

Processing of the papain precursor. Purification of the zymogen and characterization of its mechanism of processing

6 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1220970

Rat procathepsin B. Proteolytic processing to the mature form in vitro.

6 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1220970

The sequence, organization, and expression of the major cysteine protease (cruzain) from Trypanosoma cruzi

6 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1220970

Active papain renatured and processed from insoluble recombinant propapain expressed in Escherichia coli

6 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1220970

Surface activation of pro-cathepsin L

6 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1220970

Characterization of a multi-copy gene for a major stage-specific cysteine proteinase of Leishmania mexicana

6 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1220970

Leishmania mexicana cysteine proteinase-deficient mutants have attenuated virulence for mice and potentiate a Th1 response.

6 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1220970

The multiple cpb cysteine proteinase genes of Leishmania mexicana encode isoenzymes that differ in their stage regulation and substrate preferences

18 August 2018

1 reference

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Production of crystallizable cruzain, the major cysteine protease from Trypanosoma cruzi

18 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1220970

Noncovalent complexes between the lysosomal proteinase cathepsin B and its propeptide account for stable, extracellular, high molecular mass forms of the enzyme

18 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1220970

The crystal structure of cruzain: a therapeutic target for Chagas' disease

18 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1220970

Suppression by cathepsin L inhibitors of the invasion of amnion membranes by murine cancer cells

18 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1220970

Activity and deletion analysis of recombinant human cathepsin L expressed in Escherichia coli

18 August 2018

1 reference

12 December 2020

Stage-specific proteinases of Leishmania mexicana mexicana promastigotes

1 reference

12 December 2020

Potent slow-binding inhibition of cathepsin B by its propeptide

1 reference

12 December 2020

Alignment/phylogeny of the papain superfamily of cysteine proteases.

1 reference

12 December 2020

Potency and selectivity of the cathepsin L propeptide as an inhibitor of cysteine proteases

1 reference

12 December 2020

One-step purification of cathepsin D by affinity chromatography using immobilized propeptide sequences

1 reference

12 December 2020

The propeptide of Fasciola hepatica cathepsin L is a potent and selective inhibitor of the mature enzyme

1 reference

12 December 2020

10.1042/0264-6021:3470383

Identifiers

DOI

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:10749667%20AND%20SRC:MED&resulttype=core&format=json

5 November 2019

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:10749667%20AND%20SRC:MED&resulttype=core&format=json

5 November 2019

PubMed publication ID

10749667

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:10749667%20AND%20SRC:MED&resulttype=core&format=json