Deamidation accelerates amyloid formation and alters amylin fiber structure (Q41814945)

12 October 2017

Deamidation accelerates amyloid formation and alters amylin fiber structure (English)

1 reference

12 October 2017

Lauren E Buchanan

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Daniel P Raleigh

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Martin T Zanni

1 reference

12 October 2017

Emily B Dunkelberger

1 reference

12 October 2017

Peter Marek

series ordinal

1 reference

12 October 2017

Ping Cao

series ordinal

1 reference

12 October 2017

language of work or name

English

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publication date

17 July 2012

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Journal of the American Chemical Society

12 October 2017

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12 October 2017

134

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12 October 2017

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12 October 2017

12658-12667

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Two-dimensional infrared spectroscopy reveals the complex behaviour of an amyloid fibril inhibitor

12 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3410046

Two-dimensional IR spectroscopy and segmental 13C labeling reveals the domain structure of human γD-crystallin amyloid fibrils

6 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3410046

2DIR spectroscopy of human amylin fibrils reflects stable β-sheet structure

6 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3410046

The amyloid formation mechanism in human IAPP: dimers have β-strand monomer-monomer interfaces

6 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3410046

Efficient microwave-assisted synthesis of human islet amyloid polypeptide designed to facilitate the specific incorporation of labeled amino acids

6 June 2018

1 reference

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Residue-specific structural kinetics of proteins through the union of isotope labeling, mid-IR pulse shaping, and coherent 2D IR spectroscopy

6 June 2018

1 reference

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Islet amyloid deposition limits the viability of human islet grafts but not porcine islet grafts

6 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3410046

Human islet amyloid polypeptide monomers form ordered beta-hairpins: a possible direct amyloidogenic precursor

6 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3410046

Strategies for extracting structural information from 2D IR spectroscopy of amyloid: application to islet amyloid polypeptide

6 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3410046

Identification of aspartic and isoaspartic acid residues in amyloid beta peptides, including Abeta1-42, using electron-ion reactions

6 June 2018

1 reference

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2D IR provides evidence for mobile water molecules in beta-amyloid fibrils

6 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3410046

Deamidation of alpha-synuclein

6 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3410046

Two-dimensional IR spectroscopy and isotope labeling defines the pathway of amyloid formation with residue-specific resolution

6 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3410046

Deamidation destabilizes and triggers aggregation of a lens protein, betaA3-crystallin.

6 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3410046

Atomic structure of the cross-β spine of islet amyloid polypeptide (amylin)

6 June 2018

1 reference

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Two-dimensional infrared spectra of isotopically diluted amyloid fibrils from Abeta40.

6 June 2018

1 reference

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Tracking fiber formation in human islet amyloid polypeptide with automated 2D-IR spectroscopy

6 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3410046

Structure of alpha-helical membrane-bound human islet amyloid polypeptide and its implications for membrane-mediated misfolding

6 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3410046

Amide inequivalence in the fibrillar assembly of islet amyloid polypeptide

6 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3410046

Peptide conformation and supramolecular organization in amylin fibrils: constraints from solid-state NMR.

6 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3410046

Mapping protein post-translational modifications with mass spectrometry

6 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3410046

Protein posttranslational modifications: the chemistry of proteome diversifications

6 June 2018

1 reference

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Biological significance of isoaspartate and its repair system

6 June 2018

1 reference

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Islet amyloid: a critical entity in the pathogenesis of type 2 diabetes

6 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3410046

The origin of vibrational mode couplings in various secondary structural motifs of polypeptides

6 June 2018

1 reference

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Chemical modification of insulin in amyloid fibrils

6 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3410046

Islet amyloid polypeptide and type 2 diabetes

6 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3410046

Proteomic analysis of post-translational modifications

6 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3410046

Beta-cell deficit and increased beta-cell apoptosis in humans with type 2 diabetes

6 June 2018

1 reference

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Low levels of asparagine deamidation can have a dramatic effect on aggregation of amyloidogenic peptides: implications for the study of amyloid formation

6 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3410046

Deamidation of human proteins

6 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3410046

Prediction of protein deamidation rates from primary and three-dimensional structure

6 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3410046

6 June 2018

1 reference

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Isoaspartate formation and neurodegeneration in Alzheimer's disease

6 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3410046

The presence of isoaspartic acid in beta-amyloid plaques indicates plaque age.

6 June 2018

1 reference

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Islet amyloid: a long-recognized but underappreciated pathological feature of type 2 diabetes

6 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3410046

Structural alterations in the peptide backbone of beta-amyloid core protein may account for its deposition and stability in Alzheimer's disease.

6 June 2018

1 reference

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Pancreatic islet cell toxicity of amylin associated with type-2 diabetes mellitus

6 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3410046

Amylin compared with calcitonin gene-related peptide: structure, biology, and relevance to metabolic disease

6 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3410046

Deamidation of asparagine and glutamine residues in proteins and peptides: structural determinants and analytical methodology

6 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3410046

Deamidation, isomerization, and racemization at asparaginyl and aspartyl residues in peptides. Succinimide-linked reactions that contribute to protein degradation

6 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3410046

Purification and characterization of a peptide from amyloid-rich pancreases of type 2 diabetic patients

6 June 2018

1 reference

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Islet amyloid, increased A-cells, reduced B-cells and exocrine fibrosis: quantitative changes in the pancreas in type 2 diabetes.

6 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3410046

Amyloid fibrils in human insulinoma and islets of Langerhans of the diabetic cat are derived from a neuropeptide-like protein also present in normal islet cells

6 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3410046

The insulin secretory granule

6 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3410046

Islet amyloid polypeptide. A new beta cell secretory product related to islet amyloid deposits

6 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3410046

Effects of amino acid sequence, buffers, and ionic strength on the rate and mechanism of deamidation of asparagine residues in small peptides

6 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3410046

Suppression of IAPP fibrillation at anionic lipid membranes via IAPP-derived amyloid inhibitors and insulin

6 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3410046

Generation and characterization of phase and amplitude shaped femtosecond mid-IR pulses

18 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3410046

The fluorescent amino acid p-cyanophenylalanine provides an intrinsic probe of amyloid formation

18 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3410046

Isoaspartate formation at position 23 of amyloid beta peptide enhanced fibril formation and deposited onto senile plaques and vascular amyloids in Alzheimer's disease

18 August 2018

1 reference

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Isolation and identification of peptide degradation products of heat stressed pramlintide injection drug product

18 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3410046

Widespread amyloid deposition in transplanted human pancreatic islets

18 August 2018

1 reference

12 December 2020

Deamidation and disulfide bonding in human lens gamma-crystallins

1 reference

12 December 2020

Secondary structure and protein deamidation

1 reference

12 December 2020

Isolation and identification of cyclic imide and deamidation products in heat stressed pramlintide injection drug product

1 reference

12 December 2020

Incorporation of Pseudoproline Derivatives Allows the Facile Synthesis of Human IAPP, a Highly Amyloidogenic and Aggregation-Prone Polypeptide

1 reference

12 December 2020

Islet amyloid formed from diabetes-associated peptide may be pathogenic in type-2 diabetes

1 reference

12 December 2020

Characterization of the deamidated forms of recombinant hirudin

1 reference

12 December 2020

A biophysical characterization of the peptide drug pramlintide (AC137) using empirical phase diagrams

1 reference

12 December 2020

Elucidation of residue-level structure and dynamics of polypeptides via isotope-edited infrared spectroscopy

1 reference

12 December 2020

Femtosecond pulse shaping directly in the mid-IR using acousto-optic modulation

1 reference

12 December 2020

2D IR line shapes probe ovispirin peptide conformation and depth in lipid bilayers

1 reference

12 December 2020

Glutamine deamidation destabilizes human gammaD-crystallin and lowers the kinetic barrier to unfolding

1 reference

12 December 2020

Identifiers

DOI

10.1021/JA3039486

1 reference

12 October 2017

1 reference

12 October 2017

PubMed publication ID

22734583

1 reference