The synergistic inhibition of atherogenesis in apoE-/- mice between pravastatin and the sPLA2 inhibitor varespladib (A-002). (Q41814827)

12 October 2017

The synergistic inhibition of atherogenesis in apoE-/- mice between pravastatin and the sPLA2 inhibitor varespladib (A-002). (English)

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12 October 2017

Aldons J Lusis

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12 October 2017

Zory Shaposhnik

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12 October 2017

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12 October 2017

Joaquim Trias

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12 October 2017

Heather Fraser

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12 October 2017

21 November 2008

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Journal of Lipid Research

12 October 2017

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12 October 2017

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12 October 2017

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12 October 2017

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Mouse models for atherosclerosis and pharmaceutical modifiers.

12 October 2017

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Group v secretory phospholipase A2 promotes atherosclerosis: evidence from genetically altered mice

6 June 2018

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Granulocyte macrophage colony-stimulating factor regulates dendritic cell content of atherosclerotic lesions

6 June 2018

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PhospholipaseA2: a key regulator of inflammatory signalling and a connector to fibrosis development in atherosclerosis

6 June 2018

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The paraoxonase gene family and atherosclerosis

6 June 2018

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Secretory phospholipase A2.

6 June 2018

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Group V sPLA2 hydrolysis of low-density lipoprotein results in spontaneous particle aggregation and promotes macrophage foam cell formation

6 June 2018

1 reference

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Prevention of coronary and stroke events with atorvastatin in hypertensive patients who have average or lower-than-average cholesterol concentrations, in the Anglo-Scandinavian Cardiac Outcomes Trial--Lipid Lowering Arm (ASCOT-LLA): a multicentre ra

6 June 2018

1 reference

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Combined serum paraoxonase knockout/apolipoprotein E knockout mice exhibit increased lipoprotein oxidation and atherosclerosis

6 June 2018

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Structure-based design of a new class of anti-inflammatory drugs: secretory phospholipase A(2) inhibitors, SPI.

6 June 2018

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Circulating levels of secretory type II phospholipase A(2) predict coronary events in patients with coronary artery disease

6 June 2018

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Role of group II secretory phospholipase A2 in atherosclerosis: 2. Potential involvement of biologically active oxidized phospholipids

6 June 2018

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Role of group II secretory phospholipase A2 in atherosclerosis: 1. Increased atherogenesis and altered lipoproteins in transgenic mice expressing group IIa phospholipase A2.

6 June 2018

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Pharmacology of LY315920/S-5920, [[3-(aminooxoacetyl)-2-ethyl-1- (phenylmethyl)-1H-indol-4-yl]oxy] acetate, a potent and selective secretory phospholipase A2 inhibitor: A new class of anti-inflammatory drugs, SPI.

6 June 2018

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Influence of mouse apolipoprotein A-II on plasma lipoproteins in transgenic mice

6 June 2018

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Diversity of group types, regulation, and function of phospholipase A2

6 June 2018

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Rosuvastatin displays anti-atherothrombotic and anti-inflammatory properties in apoE-deficient mice.

6 June 2018

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Circulating secretory phospholipase A2 activity and risk of incident coronary events in healthy men and women: the EPIC-Norfolk study

18 August 2018

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Desensitization of platelet-derived growth factor receptor-beta by oxidized lipids in vascular cells and atherosclerotic lesions: prevention by aldehyde scavengers.

18 August 2018

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Macrophage-specific expression of group IIA sPLA2 results in accelerated atherogenesis by increasing oxidative stress

18 August 2018

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D-4F and statins synergize to render HDL antiinflammatory in mice and monkeys and cause lesion regression in old apolipoprotein E-null mice

18 August 2018

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Macrophage-specific overexpression of group IIa sPLA2 increases atherosclerosis and enhances collagen deposition

18 August 2018

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Serine protease inhibitor Serp-1 strongly impairs atherosclerotic lesion formation and induces a stable plaque phenotype in ApoE-/-mice.

18 August 2018

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Decreased atherosclerotic lesion formation in human serum paraoxonase transgenic mice

18 August 2018

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Elevating high-density lipoprotein cholesterol in apolipoprotein E-deficient mice remodels advanced atherosclerotic lesions by decreasing macrophage and increasing smooth muscle cell content

18 August 2018

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Functional blockade of platelet-derived growth factor receptor-beta but not of receptor-alpha prevents vascular smooth muscle cell accumulation in fibrous cap lesions in apolipoprotein E-deficient mice

18 August 2018

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Psychological stress and the progression of carotid artery disease.

18 August 2018

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Expression of secretory phospholipase A2s in human atherosclerosis development

18 August 2018

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12 December 2020

Group IIA phospholipase A2 mediates lung injury in intestinal ischemia-reperfusion

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12 December 2020

Secretory phospholipase A2 group V: lesion distribution, activation by arterial proteoglycans, and induction in aorta by a Western diet

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12 December 2020

Tagging SNP haplotype analysis of the secretory PLA2-V gene, PLA2G5 , shows strong association with LDL and oxLDL levels, suggesting functional distinction from sPLA2-IIA: results from the UDACS study

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12 December 2020

Overexpression of secretory phospholipase A(2) causes rapid catabolism and altered tissue uptake of high density lipoprotein cholesteryl ester and apolipoprotein A-I

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12 December 2020

10.1194/JLR.M800361-JLR200

Identifiers

DOI

1 reference

12 October 2017

1 reference

12 October 2017

PubMed publication ID

19029066

1 reference