eIF4E-bound mRNPs are substrates for nonsense-mediated mRNA decay in mammalian cells (Q41792367)

10 October 2017

title

eIF4E-bound mRNPs are substrates for nonsense-mediated mRNA decay in mammalian cells (English)

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10 October 2017

Oliver Mühlemann

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10 October 2017

Simone C Rufener

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10 October 2017

publication date

12 May 2013

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Nature Structural & Molecular Biology

10 October 2017

published in

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10 October 2017

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10 October 2017

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10 October 2017

page(s)

710-717

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Pre-mRNA processing reaches back to transcription and ahead to translation

10 October 2017

cites work

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The cellular EJC interactome reveals higher-order mRNP structure and an EJC-SR protein nexus

21 January 2018

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A nuclear cap binding protein complex involved in pre-mRNA splicing

21 January 2018

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A nuclear cap-binding complex binds Balbiani ring pre-mRNA cotranscriptionally and accompanies the ribonucleoprotein particle during nuclear export

21 January 2018

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The spliceosome deposits multiple proteins 20-24 nucleotides upstream of mRNA exon-exon junctions

21 January 2018

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The mRNA-bound proteome and its global occupancy profile on protein-coding transcripts

21 January 2018

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Insights into RNA biology from an atlas of mammalian mRNA-binding proteins

21 January 2018

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RNA regulons: coordination of post-transcriptional events

21 January 2018

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Evidence for a pioneer round of mRNA translation: mRNAs subject to nonsense-mediated decay in mammalian cells are bound by CBP80 and CBP20

21 January 2018

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The pioneer translation initiation complex is functionally distinct from but structurally overlaps with the steady-state translation initiation complex

21 January 2018

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Nonsense-mediated mRNA decay: splicing, translation and mRNP dynamics

21 January 2018

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Remodeling of the pioneer translation initiation complex involves translation and the karyopherin importin beta

21 January 2018

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The exon junction complex is detected on CBP80-bound but not eIF4E-bound mRNA in mammalian cells: dynamics of mRNP remodeling

21 January 2018

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The molecular basis for the regulation of the cap-binding complex by the importins

21 January 2018

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Importin provides a link between nuclear protein import and U snRNA export

21 January 2018

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Diverse role of three tyrosines in binding of the RNA 5' cap to the human nuclear cap binding complex

21 January 2018

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Ribosome loading onto the mRNA cap is driven by conformational coupling between eIF4G and eIF4E

21 January 2018

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NMD: a multifaceted response to premature translational termination

21 January 2018

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Binding of a novel SMG-1-Upf1-eRF1-eRF3 complex (SURF) to the exon junction complex triggers Upf1 phosphorylation and nonsense-mediated mRNA decay

21 January 2018

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21 January 2018

The meaning of nonsense

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N- and C-terminal Upf1 phosphorylations create binding platforms for SMG-6 and SMG-5:SMG-7 during NMD

21 January 2018

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Molecular mechanisms for the RNA-dependent ATPase activity of Upf1 and its regulation by Upf2

21 January 2018

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The nonsense-mediated mRNA decay SMG-1 kinase is regulated by large-scale conformational changes controlled by SMG-8.

21 January 2018

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Phosphorylation of hUPF1 induces formation of mRNA surveillance complexes containing hSMG-5 and hSMG-7

21 January 2018

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SMG7 is a 14-3-3-like adaptor in the nonsense-mediated mRNA decay pathway

21 January 2018

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Human proline-rich nuclear receptor coregulatory protein 2 mediates an interaction between mRNA surveillance machinery and decapping complex

21 January 2018

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The pioneer round of translation: features and functions

21 January 2018

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UPF1 association with the cap-binding protein, CBP80, promotes nonsense-mediated mRNA decay at two distinct steps

21 January 2018

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CBP80 promotes interaction of Upf1 with Upf2 during nonsense-mediated mRNA decay in mammalian cells

21 January 2018

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A new MIF4G domain-containing protein, CTIF, directs nuclear cap-binding protein CBP80/20-dependent translation

21 January 2018

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Pioneer round of translation occurs during serum starvation

21 January 2018

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The nonsense-mediated decay RNA surveillance pathway

21 January 2018

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Upf1 senses 3'UTR length to potentiate mRNA decay

21 January 2018

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Nonsense-containing mRNAs that accumulate in the absence of a functional nonsense-mediated mRNA decay pathway are destabilized rapidly upon its restitution

21 January 2018

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Cap-binding protein 1-mediated and eukaryotic translation initiation factor 4E-mediated pioneer rounds of translation in yeast

21 January 2018

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Ribosome occupancy of the yeast CPA1 upstream open reading frame termination codon modulates nonsense-mediated mRNA decay

21 January 2018

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Structural basis of m7GpppG binding to the nuclear cap-binding protein complex

21 January 2018

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Circularization of mRNA by eukaryotic translation initiation factors

21 January 2018

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A newly identified N-terminal amino acid sequence of human eIF4G binds poly(A)-binding protein and functions in poly(A)-dependent translation

21 January 2018

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Interaction of eukaryotic translation initiation factor 4G with the nuclear cap-binding complex provides a link between nuclear and cytoplasmic functions of the m(7) guanosine cap.

21 January 2018

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eIF4G is required for the pioneer round of translation in mammalian cells

21 January 2018

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Posttranscriptional gene regulation by spatial rearrangement of the 3' untranslated region

21 January 2018

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Evidence for reassociation of RNA-binding proteins after cell lysis: implications for the interpretation of immunoprecipitation analyses

21 January 2018

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EJC-independent degradation of nonsense immunoglobulin-mu mRNA depends on 3' UTR length

21 January 2018

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Concerted action of poly(A) nucleases and decapping enzyme in mammalian mRNA turnover

21 January 2018

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Mechanism of mRNA deadenylation: evidence for a molecular interplay between translation termination factor eRF3 and mRNA deadenylases

21 January 2018

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Quantitative characterization of Tob interactions provides the thermodynamic basis for translation termination-coupled deadenylase regulation

21 January 2018

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Recognition of nonsense mRNA: towards a unified model

21 January 2018

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NMD factors UPF2 and UPF3 bridge UPF1 to the exon junction complex and stimulate its RNA helicase activity

21 January 2018

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Mammalian poly(A)-binding protein is a eukaryotic translation initiation factor, which acts via multiple mechanisms

21 January 2018

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A GFP-based reporter system to monitor nonsense-mediated mRNA decay

21 January 2018

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Autoregulation of the nonsense-mediated mRNA decay pathway in human cells

21 January 2018

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Erratum: Regulation of cytoplasmic mRNA decay

21 January 2018

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CLIP-seq of eIF4AIII reveals transcriptome-wide mapping of the human exon junction complex

21 January 2018

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The Yeast Nuclear Cap Binding Complex Can Interact with Translation Factor eIF4G and Mediate Translation Initiation

31 March 2020

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Translation is required to remove Y14 from mRNAs in the cytoplasm

31 March 2020

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Stopped-flow and Brownian dynamics studies of electrostatic effects in the kinetics of binding of 7-methyl-GpppG to the protein eIF4E

31 March 2020

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eIF4G Dramatically Enhances the Binding of eIF4E to the mRNA 5′-Cap Structure

31 March 2020

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Nonsense-mediated mRNA decay - mechanisms of substrate mRNA recognition and degradation in mammalian cells

31 March 2020

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Pioneer round of translation mediated by nuclear cap-binding proteins CBP80/20 occurs during prolonged hypoxia

31 March 2020

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Regulation of cytoplasmic mRNA decay

31 March 2020

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31 March 2020

Identifiers

DOI

10.1038/NSMB.2576

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10 October 2017

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