Regulation of mitochondrial permeability transition pore by PINK1. (Q41786008)

9 October 2017

Regulation of mitochondrial permeability transition pore by PINK1. (English)

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9 October 2017

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9 October 2017

Clement A Gautier

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9 October 2017

Emilie Giaime

1 reference

9 October 2017

Erica Caballero

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9 October 2017

Lucía Núñez

1 reference

9 October 2017

Zhiyin Song

1 reference

9 October 2017

David Chan

1 reference

9 October 2017

Jie Shen

1 reference

9 October 2017

25 May 2012

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Molecular Neurodegeneration

9 October 2017

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9 October 2017

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9 October 2017

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describes a project that uses

9 October 2017

ImageJ

1 reference

11 June 2022

https://www.ebi.ac.uk/europepmc/webservices/rest/PMC3405481/fullTextXML

inferred from PubMed Central ID database lookup

cites work

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Bioenergetic consequences of PINK1 mutations in Parkinson disease

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The PINK1/Parkin pathway regulates mitochondrial dynamics and function in mammalian hippocampal and dopaminergic neurons

6 June 2018

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Depletion of PINK1 affects mitochondrial metabolism, calcium homeostasis and energy maintenance

6 June 2018

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Oxidative stress alters the regulatory control of p66Shc and Akt in PINK1 deficient cells.

6 June 2018

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The mitochondrial fusion-promoting factor mitofusin is a substrate of the PINK1/parkin pathway

6 June 2018

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Parkinson's disease mutations in PINK1 result in decreased Complex I activity and deficient synaptic function

6 June 2018

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Presenilins are essential for regulating neurotransmitter release

6 June 2018

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Loss of parkin or PINK1 function increases Drp1-dependent mitochondrial fragmentation

6 June 2018

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Calcium elevation in mitochondria is the main Ca2+ requirement for mitochondrial permeability transition pore (mPTP) opening.

6 June 2018

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Mitochondrial alterations in PINK1 deficient cells are influenced by calcineurin-dependent dephosphorylation of dynamin-related protein 1.

6 June 2018

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Parkinson phenotype in aged PINK1-deficient mice is accompanied by progressive mitochondrial dysfunction in absence of neurodegeneration

6 June 2018

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Effect of transient and permanent permeability transition pore opening on NAD(P)H localization in intact cells.

6 June 2018

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Indirect regulation of presenilins in CREB-mediated transcription.

6 June 2018

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PINK1-associated Parkinson's disease is caused by neuronal vulnerability to calcium-induced cell death

6 June 2018

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Loss of PINK1 function promotes mitophagy through effects on oxidative stress and mitochondrial fission

6 June 2018

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Silencing of PINK1 expression affects mitochondrial DNA and oxidative phosphorylation in dopaminergic cells

6 June 2018

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PINK1 defect causes mitochondrial dysfunction, proteasomal deficit and alpha-synuclein aggregation in cell culture models of Parkinson's disease

6 June 2018

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The Parkinson's disease genes pink1 and parkin promote mitochondrial fission and/or inhibit fusion in Drosophila

6 June 2018

1 reference

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Loss of PINK1 causes mitochondrial functional defects and increased sensitivity to oxidative stress

6 June 2018

1 reference

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The kinase domain of mitochondrial PINK1 faces the cytoplasm

6 June 2018

1 reference

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Pink1 regulates mitochondrial dynamics through interaction with the fission/fusion machinery

6 June 2018

1 reference

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Primary coenzyme Q deficiency in Pdss2 mutant mice causes isolated renal disease

6 June 2018

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The PINK1/Parkin pathway regulates mitochondrial morphology

6 June 2018

1 reference

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Loss-of-function of human PINK1 results in mitochondrial pathology and can be rescued by parkin

6 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3405481

Visualization and quantification of mitochondrial dynamics in living animal cells.

6 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3405481

Cyclosporine A attenuates mitochondrial permeability transition and improves mitochondrial respiratory function in cardiomyocytes isolated from dogs with heart failure

6 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3405481

Drosophila pink1 is required for mitochondrial function and interacts genetically with parkin

6 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3405481

Mitochondrial dysfunction in Drosophila PINK1 mutants is complemented by parkin

6 June 2018

1 reference

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Distinct characteristics of Ca(2+)-induced depolarization of isolated brain and liver mitochondria

6 June 2018

1 reference

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Wild-type PINK1 prevents basal and induced neuronal apoptosis, a protective effect abrogated by Parkinson disease-related mutations

6 June 2018

1 reference

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Hereditary early-onset Parkinson's disease caused by mutations in PINK1

6 June 2018

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Mitochondrial dysfunction and oxidative damage in parkin-deficient mice

6 June 2018

1 reference

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Mitofusins Mfn1 and Mfn2 coordinately regulate mitochondrial fusion and are essential for embryonic development

6 June 2018

1 reference

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Study on the relationship between calcium-induced calcium release from mitochondria and PTP opening

6 June 2018

1 reference

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Chronic systemic pesticide exposure reproduces features of Parkinson's disease

6 June 2018

1 reference

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Mitochondria and cell death. Mechanistic aspects and methodological issues

6 June 2018

1 reference

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Transient and long-lasting openings of the mitochondrial permeability transition pore can be monitored directly in intact cells by changes in mitochondrial calcein fluorescence

6 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3405481

From calcium signaling to cell death: two conformations for the mitochondrial permeability transition pore. Switching from low- to high-conductance state

6 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3405481

Cyclosporin A, but not FK 506, protects mitochondria and neurons against hypoglycemic damage and implicates the mitochondrial permeability transition in cell death.

6 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3405481

Regulation of the permeability transition pore in skeletal muscle mitochondria. Modulation By electron flow through the respiratory chain complex i.

6 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3405481

Imaging the permeability pore transition in single mitochondria

6 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3405481

Mitochondria Are Excitable Organelles Capable of Generating and Conveying Electrical and Calcium Signals

6 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3405481

Chronic Parkinsonism in humans due to a product of meperidine-analog synthesis

6 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3405481

Bongkrekic acid. An inhibitor of the adenine nucleotide translocase of mitochondria

6 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3405481

Inhibition of Ca2(+)-induced large-amplitude swelling of liver and heart mitochondria by cyclosporin is probably caused by the inhibitor binding to mitochondrial-matrix peptidyl-prolyl cis-trans isomerase and preventing it interacting with the adeni

6 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3405481

Calcineurin is a common target of cyclophilin-cyclosporin A and FKBP-FK506 complexes

6 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3405481

The antioxidant Trolox helps recovery from the familial Parkinson's disease-specific mitochondrial deficits caused by PINK1- and DJ-1-deficiency in dopaminergic neuronal cells

6 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3405481

Mitochondrial membrane potential decrease caused by loss of PINK1 is not due to proton leak, but to respiratory chain defects.

18 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3405481

Local control of mitochondrial membrane potential, permeability transition pore and reactive oxygen species by calcium and calmodulin in rat ventricular myocytes

18 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3405481

Mitochondrial respiratory dysfunction in familiar parkinsonism associated with PINK1 mutation.

18 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3405481

Role of alpha-tocopherol in the regulation of mitochondrial permeability transition.

18 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3405481

Mechanisms of acetaminophen-induced hepatotoxicity: role of oxidative stress and mitochondrial permeability transition in freshly isolated mouse hepatocytes

18 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3405481

Effect of amyloid beta-peptide on permeability transition pore: a comparative study.

18 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3405481

Mitochondrial permeability transition can be directly monitored in living neurons

18 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3405481

Imaging the mitochondrial permeability transition pore in intact cells.

18 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3405481

Mitochondrial complex I deficiency in Parkinson's disease

18 August 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/22630785

12 December 2020

inferred from PubMed ID database lookup

Organelle isolation: functional mitochondria from mouse liver, muscle and cultured filroblasts

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/22630785

12 December 2020

inferred from PubMed ID database lookup

Selectivity of Inhibition of Na+-Ca2+ Exchange of Heart Mitochondria by Benzothiazepine CGP-37157

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/22630785

12 December 2020

inferred from PubMed ID database lookup

Identifiers

DOI

10.1186/1750-1326-7-22

1 reference

Dimensions Publication ID

9 October 2017

0 references

1 reference

9 October 2017

PubMed publication ID

22630785

1 reference