Evidence for multiple effects of ProTxII on activation gating in Na(V)1.5. (Q41763825)

9 October 2017

Evidence for multiple effects of ProTxII on activation gating in Na(V)1.5. (English)

1 reference

9 October 2017

Gabrielle B Edgerton

1 reference

9 October 2017

Kenneth M Blumenthal

series ordinal

1 reference

9 October 2017

Dorothy A Hanck

series ordinal

1 reference

9 October 2017

9 July 2008

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9 October 2017

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inferred from page(s)

published in

Toxicon

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9 October 2017

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9 October 2017

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9 October 2017

489-500

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Inhibition of sodium channel gating by trapping the domain II voltage sensor with protoxin II.

9 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2613288

Atomic structure of a voltage-dependent K+ channel in a lipid membrane-like environment

6 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2613288

Tarantula toxins interact with voltage sensors within lipid membranes

6 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2613288

Molecular interactions of the gating modifier toxin ProTx-II with NaV 1.5: implied existence of a novel toxin binding site coupled to activation

6 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2613288

Site-3 toxins and cardiac sodium channels

6 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2613288

ProTx-I and ProTx-II: gating modifiers of voltage-gated sodium channels

6 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2613288

Novel paradigms on scorpion toxins that affects the activating mechanism of sodium channels

6 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2613288

Subtype specificity of scorpion beta-toxin Tz1 interaction with voltage-gated sodium channels is determined by the pore loop of domain 3.

6 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2613288

Structure of the KvAP voltage-dependent K+ channel and its dependence on the lipid membrane

6 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2613288

Voltage-sensor activation with a tarantula toxin as cargo.

6 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2613288

Crystal structure of a mammalian voltage-dependent Shaker family K+ channel

6 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2613288

Charge immobilization of the voltage sensor in domain IV is independent of sodium current inactivation

6 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2613288

X-ray structure of a voltage-dependent K+ channel

6 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2613288

Two tarantula peptides inhibit activation of multiple sodium channels

6 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2613288

Molecular mechanisms of neurotoxin action on voltage-gated sodium channels.

6 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2613288

Localization and molecular determinants of the Hanatoxin receptors on the voltage-sensing domains of a K(+) channel

6 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2613288

Voltage sensors in domains III and IV, but not I and II, are immobilized by Na+ channel fast inactivation

6 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2613288

Mapping the receptor site for hanatoxin, a gating modifier of voltage-dependent K+ channels.

6 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2613288

Hanatoxin modifies the gating of a voltage-dependent K+ channel through multiple binding sites

6 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2613288

Effects of III-IV linker mutations on human heart Na+ channel inactivation gating

6 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2613288

A mutant of TTX-resistant cardiac sodium channels with TTX-sensitive properties

6 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2613288

Mechanisms of extracellular divalent and trivalent cation block of the sodium current in canine cardiac Purkinje cells

6 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2613288

Extracellular divalent and trivalent cation effects on sodium current kinetics in single canine cardiac Purkinje cells

6 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2613288

Interaction between extracellular Hanatoxin and the resting conformation of the voltage-sensor paddle in Kv channels

6 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2613288

Differential phospholipid binding by site 3 and site 4 toxins. Implications for structural variability between voltage-sensitive sodium channel domains

18 August 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/18657562

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

An inner pore residue (Asn406) in the Nav1.5 channel controls slow inactivation and enhances mibefradil block to T-type Ca2+ channel levels

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/18657562

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Time-dependent changes in kinetics of Na+ current in single canine cardiac Purkinje cells

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/18657562

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1016/J.TOXICON.2008.06.023

1 reference

9 October 2017

1 reference

9 October 2017

PubMed publication ID

18657562

1 reference