Major histocompatibility complex-directed susceptibility to rheumatoid arthritis (Q41722145)

8 October 2017

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title

Major histocompatibility complex-directed susceptibility to rheumatoid arthritis (English)

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8 October 2017

Major Histocompatibility Complex-Directed Susceptibility to Rheumatoid Arthritis (English)

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Gerald T. Nepom

Nepom GT

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8 October 2017

publication date

1 January 1998

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8 October 2017

1998

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published in

Advances in Immunology

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8 October 2017

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8 October 2017

page(s)

315-332

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The susceptibility sequence to rheumatoid arthritis is a cross-reactive B cell epitope shared by the Escherichia coli heat shock protein dnaJ and the histocompatibility leukocyte antigen DRB10401 molecule

8 October 2017

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HLA-DR4 and HLA-DR10 motifs that carry susceptibility to rheumatoid arthritis bind 70-kD heat shock proteins.

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Serological recognition of HLA-DR allodeterminant corresponding to DNA sequence involved in gene conversion

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HLA class II sequence polymorphisms and susceptibility to rheumatoid arthritis in Greeks. The HLA-DR beta shared-epitope hypothesis accounts for the disease in only a minority of Greek patients

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New perspectives on treating rheumatoid arthritis

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Destructive arthritis, rheumatoid factor, and HLA-DR4. Susceptibility versus severity, a case-control study

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Naturally processed peptides from two disease-resistance-associated HLA-DR13 alleles show related sequence motifs and the effects of the dimorphism at position 86 of the HLA-DR beta chain

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A distinctive peptide binding motif for HLA-DRB1*0407, an HLA-DR4 subtype not associated with rheumatoid arthritis

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7 January 2021

The set of naturally processed peptides displayed by DR molecules is tuned by polymorphism of residue 86

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Natural ligand motifs of closely related HLA-DR4 molecules predict features of rheumatoid arthritis associated peptides

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7 January 2021

Pocket 4 of the HLA-DR(alpha,beta 1*0401) molecule is a major determinant of T cells recognition of peptide

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HLA-DR alleles with naturally occurring amino acid substitutions and risk for development of rheumatoid arthritis

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Ancestral major histocompatibility complex DRB genes beget conserved patterns of localized polymorphisms

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MHC-DRB allelic sequences incorporate distinct intragenic trans-specific segments

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The structure of an intermediate in class II MHC maturation: CLIP bound to HLA-DR3

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Genetic typing of patients with inflammatory arthritis at presentation can be used to predict outcome

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The shared epitope hypothesis. An approach to understanding the molecular genetics of susceptibility to rheumatoid arthritis

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Allelic diversity is generated by intraexon sequence exchange at the DRB1 locus of primates

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Precise prediction of major histocompatibility complex class II-peptide interaction based on peptide side chain scanning

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Peptide binding specificity of HLA-DR4 molecules: correlation with rheumatoid arthritis association

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Structural requirements for recognition of the HLA-Dw14 class II epitope: a key HLA determinant associated with rheumatoid arthritis

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7 January 2021

Novel genes in the human major histocompatibility complex class-II region

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7 January 2021

MOLSCRIPT: a program to produce both detailed and schematic plots of protein structures

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7 January 2021

HLA-DQB1 codon 57 is critical for peptide binding and recognition.

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7 January 2021

Evolution of major histocompatibility complex class II allelic diversity: direct descent in mice and humans

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Allele specificity of structural requirement for peptides bound to HLA-DRB1*0405 and -DRB1*0406 complexes: implication for the HLA-associated susceptibility to methimazole-induced insulin autoimmune syndrome

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Most African-American patients with rheumatoid arthritis do not have the rheumatoid antigenic determinant (epitope)

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Autoreactive T cells from a type I diabetic recognize multiple class II products

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Critical contribution of beta chain residue 57 in peptide binding ability of both HLA-DR and -DQ molecules

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HLA genes associated with rheumatoid arthritis. Identification of susceptibility alleles using specific oligonucleotide probes

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Recognition of altered self major histocompatibility complex molecules modulated by specific peptide interactions

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7 January 2021

Treatment of rheumatoid arthritis with methotrexate alone, sulfasalazine and hydroxychloroquine, or a combination of all three medications

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7 January 2021

Associations of HLA-DR4 with rheumatoid factor and radiographic severity in rheumatoid arthritis

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7 January 2021

A Structural Model for TCR Recognition of the HLA Class II Shared Epitope Sequence Implicated in Susceptibility to Rheumatoid Arthritis

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7 January 2021

Use of T cell receptor/HLA-DRB1*04 molecular modeling to predict site-specific interactions for the DR shared epitope associated with rheumatoid arthritis

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7 January 2021

Cloning of the HLA class II region in yeast artificial chromosomes

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7 January 2021

MHC ligands and peptide motifs: first listing

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HLA-DRB1 genes and disease severity in rheumatoid arthritis. The MIRA Trial Group. Minocycline in Rheumatoid Arthritis

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7 January 2021

Rheumatoid arthritis may be primarily associated with HLA-DR4 molecules sharing a particular sequence at residues 67-74.

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7 January 2021

Prediction of peptide affinity to HLA DRB1*0401.

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7 January 2021

Susceptibility to rheumatoid arthritis maps to a T-cell epitope shared by the HLA-Dw4 DR beta-1 chain and the Epstein-Barr virus glycoprotein gp110.

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7 January 2021

Immunogenetic similarities between patients with Felty's syndrome and those with clonal expansions of large granular lymphocytes in rheumatoid arthritis

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7 January 2021

Crystal structure of the human class II MHC protein HLA-DR1 complexed with an influenza virus peptide

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7 January 2021

Presentation of self peptides by dendritic cells: possible implications for the pathogenesis of rheumatoid arthritis

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7 January 2021

Combination Therapy with Cyclosporine and Methotrexate in Severe Rheumatoid Arthritis

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7 January 2021

Association of HLA-DR4 with a more progressive disease course in patients with rheumatoid arthritis. Results of a followup study

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7 January 2021

HLA markers and prediction of clinical course and outcome in rheumatoid arthritis

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7 January 2021

The influence of HLA-DRB1 genes on disease severity in rheumatoid arthritis

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7 January 2021

Correlation between disease phenotype and genetic heterogeneity in rheumatoid arthritis

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7 January 2021

Association of HLA–Dw16 with rheumatoid arthritis in Yakima Indians. Further evidence for the “shared epitope” hypothesis

1 reference

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7 January 2021

HLA-DR4 subtype frequencies in rheumatoid arthritis indicate that DRB1 is the major susceptibility locus within the HLA class II region

1 reference

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7 January 2021

Negatively charged residues interacting with the p4 pocket confer binding specificity to DRB1*0401

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7 January 2021

Could HLA-DRB1 be the protective locus in rheumatoid arthritis?

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7 January 2021

Immune response of HLA-DQ8 transgenic mice to peptides from the third hypervariable region of HLA-DRB1 correlates with predisposition to rheumatoid arthritis

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7 January 2021

10.1016/S0065-2776(08)60563-5

Identifiers

DOI

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