Molecular aspects of the relationship between cancer and aging: tumor suppressor activity during cellular senescence (Q41702987)

7 October 2017

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title

Molecular aspects of the relationship between cancer and aging: tumor suppressor activity during cellular senescence (English)

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7 October 2017

Garkavtsev I

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7 October 2017

Hull C

series ordinal

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7 October 2017

Riabowol K

series ordinal

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7 October 2017

publication date

1 January 1998

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7 October 2017

published in

Experimental Gerontology

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7 October 2017

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7 October 2017

issue

1-2

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7 October 2017

page(s)

81-94

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Investigation of the role of G1/S cell cycle mediators in cellular senescence

7 October 2017

cites work

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https://api.crossref.org/works/10.1016%2FS0531-5565%2897%2900086-7

7 January 2021

Increased activity of p53 in senescing fibroblasts

1 reference

https://api.crossref.org/works/10.1016%2FS0531-5565%2897%2900086-7

7 January 2021

Overexpression of Cyclin D1 Blocks Proliferation of Normal Diploid Fibroblasts

1 reference

https://api.crossref.org/works/10.1016%2FS0531-5565%2897%2900086-7

7 January 2021

The effect of donor age on the in vitro life span of cultured human arterial smooth-muscle cells

1 reference

https://api.crossref.org/works/10.1016%2FS0531-5565%2897%2900086-7

7 January 2021

Radiation-induced cell cycle arrest compromised by p21 deficiency

1 reference

https://api.crossref.org/works/10.1016%2FS0531-5565%2897%2900086-7

7 January 2021

SV40-induced immortalization of human cells

1 reference

https://api.crossref.org/works/10.1016%2FS0531-5565%2897%2900086-7

7 January 2021

Induction of the growth inhibitor IGF-binding protein 3 by p53

1 reference

https://api.crossref.org/works/10.1016%2FS0531-5565%2897%2900086-7

7 January 2021

Replicative senescence: an old lives' tale?

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https://api.crossref.org/works/10.1016%2FS0531-5565%2897%2900086-7

7 January 2021

Cancer progression and p53.

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https://api.crossref.org/works/10.1016%2FS0531-5565%2897%2900086-7

7 January 2021

Activity of RNA polymerase I transcription factor UBF blocked by Rb gene product

1 reference

https://api.crossref.org/works/10.1016%2FS0531-5565%2897%2900086-7

7 January 2021

Modulation of activity of the promoter of the human MDR1 gene by Ras and p53.

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https://api.crossref.org/works/10.1016%2FS0531-5565%2897%2900086-7

7 January 2021

Expression of growth arrest-specific (gas) genes in senescent murine cells.

1 reference

https://api.crossref.org/works/10.1016%2FS0531-5565%2897%2900086-7

7 January 2021

Mice Lacking p21CIP1/WAF1 undergo normal development, but are defective in G1 checkpoint control

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https://api.crossref.org/works/10.1016%2FS0531-5565%2897%2900086-7

7 January 2021

DNA damage triggers a prolonged p53-dependent G1 arrest and long-term induction of Cip1 in normal human fibroblasts

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https://api.crossref.org/works/10.1016%2FS0531-5565%2897%2900086-7

7 January 2021

A biomarker that identifies senescent human cells in culture and in aging skin in vivo

1 reference

https://api.crossref.org/works/10.1016%2FS0531-5565%2897%2900086-7

7 January 2021

Altered regulation of G1 cyclins in senescent human diploid fibroblasts: accumulation of inactive cyclin E-Cdk2 and cyclin D1-Cdk2 complexes

1 reference

https://api.crossref.org/works/10.1016%2FS0531-5565%2897%2900086-7

7 January 2021

T cell cultures and the Hayflick limit.

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https://api.crossref.org/works/10.1016%2FS0531-5565%2897%2900086-7

7 January 2021

WAF1, a potential mediator of p53 tumor suppression

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https://api.crossref.org/works/10.1016%2FS0531-5565%2897%2900086-7

7 January 2021

A syndrome of multiorgan hyperplasia with features of gigantism, tumorigenesis, and female sterility in p27(Kip1)-deficient mice

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https://api.crossref.org/works/10.1016%2FS0531-5565%2897%2900086-7

7 January 2021

E2F-1 functions in mice to promote apoptosis and suppress proliferation

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https://api.crossref.org/works/10.1016%2FS0531-5565%2897%2900086-7

7 January 2021

A human DNA segment with properties of the gene that predisposes to retinoblastoma and osteosarcoma

1 reference

https://api.crossref.org/works/10.1016%2FS0531-5565%2897%2900086-7

7 January 2021

A transcriptionally active DNA-binding site for human p53 protein complexes

1 reference

https://api.crossref.org/works/10.1016%2FS0531-5565%2897%2900086-7

7 January 2021

Suppression of the novel growth inhibitor p33ING1 promotes neoplastic transformation

1 reference

https://api.crossref.org/works/10.1016%2FS0531-5565%2897%2900086-7

7 January 2021

Cellular localization and chromosome mapping of a novel candidate tumor suppressor gene (ING1)

1 reference

https://api.crossref.org/works/10.1016%2FS0531-5565%2897%2900086-7

7 January 2021

Extension of the replicative life span of human diploid fibroblasts by inhibition of the p33ING1 candidate tumor suppressor

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https://api.crossref.org/works/10.1016%2FS0531-5565%2897%2900086-7

7 January 2021

Wild-type p53 can down-modulate the activity of various promoters

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https://api.crossref.org/works/10.1016%2FS0531-5565%2897%2900086-7

7 January 2021

Replicative senescence: the human fibroblast comes of age.

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https://api.crossref.org/works/10.1016%2FS0531-5565%2897%2900086-7

7 January 2021

Insulin-like growth factor binding protein 3 accumulates to high levels in culture medium of senescent and quiescent human fibroblasts.

1 reference

https://api.crossref.org/works/10.1016%2FS0531-5565%2897%2900086-7

7 January 2021

Growth suppression by p18, a p16INK4/MTS1- and p14INK4B/MTS2-related CDK6 inhibitor, correlates with wild-type pRb function

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https://api.crossref.org/works/10.1016%2FS0531-5565%2897%2900086-7

7 January 2021

Correlation of terminal cell cycle arrest of skeletal muscle with induction of p21 by MyoD.

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https://api.crossref.org/works/10.1016%2FS0531-5565%2897%2900086-7

7 January 2021

p15INK4B is a potential effector of TGF-beta-induced cell cycle arrest

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https://api.crossref.org/works/10.1016%2FS0531-5565%2897%2900086-7

7 January 2021

Cooperative effect of antisense-Rb and antisense-p53 oligomers on the extension of life span in human diploid fibroblasts, TIG-1.

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https://api.crossref.org/works/10.1016%2FS0531-5565%2897%2900086-7

7 January 2021

Regulation of p16CDKN2 expression and its implications for cell immortalization and senescence

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https://api.crossref.org/works/10.1016%2FS0531-5565%2897%2900086-7

7 January 2021

Abnormalities in structure and expression of the human retinoblastoma gene in SCLC.

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https://api.crossref.org/works/10.1016%2FS0531-5565%2897%2900086-7

7 January 2021

Telomeres shorten during ageing of human fibroblasts

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https://api.crossref.org/works/10.1016%2FS0531-5565%2897%2900086-7

7 January 2021

Inhibition of cyclin-dependent kinases by p21

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https://api.crossref.org/works/10.1016%2FS0531-5565%2897%2900086-7

7 January 2021

THE LIMITED IN VITRO LIFETIME OF HUMAN DIPLOID CELL STRAINS

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https://api.crossref.org/works/10.1016%2FS0531-5565%2897%2900086-7

7 January 2021

Regulation of retinoblastoma protein functions by ectopic expression of human cyclins

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https://api.crossref.org/works/10.1016%2FS0531-5565%2897%2900086-7

7 January 2021

Integration of cell cycle control with transcriptional regulation by the retinoblastoma protein

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https://api.crossref.org/works/10.1016%2FS0531-5565%2897%2900086-7

7 January 2021

Germline p16 mutations in familial melanoma

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https://api.crossref.org/works/10.1016%2FS0531-5565%2897%2900086-7

7 January 2021

A cell cycle regulator potentially involved in genesis of many tumor types

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https://api.crossref.org/works/10.1016%2FS0531-5565%2897%2900086-7

7 January 2021

Identification of p53 as a sequence-specific DNA-binding protein

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https://api.crossref.org/works/10.1016%2FS0531-5565%2897%2900086-7

7 January 2021

Specific Association of Human Telomerase Activity with Immortal Cells and Cancer

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https://api.crossref.org/works/10.1016%2FS0531-5565%2897%2900086-7

7 January 2021

Enhanced growth of mice lacking the cyclin-dependent kinase inhibitor function of p27(Kip1).

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https://api.crossref.org/works/10.1016%2FS0531-5565%2897%2900086-7

7 January 2021

p53: puzzle and paradigm

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https://api.crossref.org/works/10.1016%2FS0531-5565%2897%2900086-7

7 January 2021

Increased p53 Protein Associated with Aging in Human Diploid Fibroblasts

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https://api.crossref.org/works/10.1016%2FS0531-5565%2897%2900086-7

7 January 2021

The retinoblastoma susceptibility gene encodes a nuclear phosphoprotein associated with DNA binding activity

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https://api.crossref.org/works/10.1016%2FS0531-5565%2897%2900086-7

7 January 2021

The tumor suppressor genes

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https://api.crossref.org/works/10.1016%2FS0531-5565%2897%2900086-7

7 January 2021

Characterization of a 54K Dalton cellular SV40 tumor antigen present in SV40-transformed cells and uninfected embryonal carcinoma cells

1 reference

https://api.crossref.org/works/10.1016%2FS0531-5565%2897%2900086-7

7 January 2021

Transcriptional activation of the Cdk inhibitor p21 by vitamin D3 leads to the induced differentiation of the myelomonocytic cell line U937.

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https://api.crossref.org/works/10.1016%2FS0531-5565%2897%2900086-7

7 January 2021

Existence of high abundance antiproliferative mRNA's in senescent human diploid fibroblasts

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https://api.crossref.org/works/10.1016%2FS0531-5565%2897%2900086-7

7 January 2021

Absence of p53 allows direct immortalization of hematopoietic cells by the myc and raf oncogenes

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https://api.crossref.org/works/10.1016%2FS0531-5565%2897%2900086-7

7 January 2021

Regulation of gene expression and transcription factor binding activity during cellular aging.

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https://api.crossref.org/works/10.1016%2FS0531-5565%2897%2900086-7

7 January 2021

Principles of CDK regulation

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https://api.crossref.org/works/10.1016%2FS0531-5565%2897%2900086-7

7 January 2021

Diverse gene sequences are overexpressed in werner syndrome fibroblasts undergoing premature replicative senescence

1 reference

https://api.crossref.org/works/10.1016%2FS0531-5565%2897%2900086-7

7 January 2021

Mice lacking p27(Kip1) display increased body size, multiple organ hyperplasia, retinal dysplasia, and pituitary tumors

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https://api.crossref.org/works/10.1016%2FS0531-5565%2897%2900086-7

7 January 2021

Deletions of the cyclin-dependent kinase-4 inhibitor gene in multiple human cancers

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https://api.crossref.org/works/10.1016%2FS0531-5565%2897%2900086-7

7 January 2021

Cloning of senescent cell-derived inhibitors of DNA synthesis using an expression screen

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https://api.crossref.org/works/10.1016%2FS0531-5565%2897%2900086-7

7 January 2021

Human cyclin E, a nuclear protein essential for the G1-to-S phase transition

1 reference

https://api.crossref.org/works/10.1016%2FS0531-5565%2897%2900086-7

7 January 2021

Mutations and altered expression of p16INK4 in human cancer.

1 reference

https://api.crossref.org/works/10.1016%2FS0531-5565%2897%2900086-7

7 January 2021

p27Kip1, a cyclin-Cdk inhibitor, links transforming growth factor-beta and contact inhibition to cell cycle arrest

1 reference

https://api.crossref.org/works/10.1016%2FS0531-5565%2897%2900086-7

7 January 2021

Transcription factor activity during cellular aging of human diploid fibroblasts

1 reference

https://api.crossref.org/works/10.1016%2FS0531-5565%2897%2900086-7

7 January 2021

Expression of cell cycle-dependent genes in young and senescent WI-38 fibroblasts

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https://api.crossref.org/works/10.1016%2FS0531-5565%2897%2900086-7

7 January 2021

Alterations in p53 and p16INK4 expression and telomere length during spontaneous immortalization of Li-Fraumeni syndrome fibroblasts

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https://api.crossref.org/works/10.1016%2FS0531-5565%2897%2900086-7

7 January 2021

Evidence for a relationship between longevity of mammalian species and life spans of normal fibroblasts in vitro and erythrocytes in vivo

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https://api.crossref.org/works/10.1016%2FS0531-5565%2897%2900086-7

7 January 2021

Repression of the interleukin 6 gene promoter by p53 and the retinoblastoma susceptibility gene product

1 reference

https://api.crossref.org/works/10.1016%2FS0531-5565%2897%2900086-7

7 January 2021

Measurement of DNA content and cell volume in senescent human fibroblasts utilizing flow multiparameter single cell analysis

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https://api.crossref.org/works/10.1016%2FS0531-5565%2897%2900086-7

7 January 2021

A new regulatory motif in cell-cycle control causing specific inhibition of cyclin D/CDK4

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https://api.crossref.org/works/10.1016%2FS0531-5565%2897%2900086-7

7 January 2021

Wild-type p53 binds to the TATA-binding protein and represses transcription

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https://api.crossref.org/works/10.1016%2FS0531-5565%2897%2900086-7

7 January 2021

A role for both RB and p53 in the regulation of human cellular senescence

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https://api.crossref.org/works/10.1016%2FS0531-5565%2897%2900086-7

7 January 2021

Inhibitors of mammalian G1 cyclin-dependent kinases

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https://api.crossref.org/works/10.1016%2FS0531-5565%2897%2900086-7

7 January 2021

Defining cellular senescence in IMR-90 cells: a flow cytometric analysis

1 reference

https://api.crossref.org/works/10.1016%2FS0531-5565%2897%2900086-7

7 January 2021

Failure to phosphorylate the retinoblastoma gene product in senescent human fibroblasts

1 reference

https://api.crossref.org/works/10.1016%2FS0531-5565%2897%2900086-7

7 January 2021

Immortalization of conditionally transformed chicken cells: loss of normal p53 expression is an early step that is independent of cell transformation.

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https://api.crossref.org/works/10.1016%2FS0531-5565%2897%2900086-7

7 January 2021

Distinct roles for cyclin-dependent kinases in cell cycle control

1 reference

https://api.crossref.org/works/10.1016%2FS0531-5565%2897%2900086-7

7 January 2021

The p21 inhibitor of cyclin-dependent kinases controls DNA replication by interaction with PCNA

1 reference

https://api.crossref.org/works/10.1016%2FS0531-5565%2897%2900086-7

7 January 2021

Repression of RNA polymerase III transcription by the retinoblastoma protein

1 reference

https://api.crossref.org/works/10.1016%2FS0531-5565%2897%2900086-7

7 January 2021

Differential CDK-inhibitor gene expression in aging human diploid fibroblasts

1 reference

https://api.crossref.org/works/10.1016%2FS0531-5565%2897%2900086-7

7 January 2021

Reversible cellular senescence: implications for immortalization of normal human diploid fibroblasts

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https://api.crossref.org/works/10.1016%2FS0531-5565%2897%2900086-7

7 January 2021

p21 is a universal inhibitor of cyclin kinases

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https://api.crossref.org/works/10.1016%2FS0531-5565%2897%2900086-7

7 January 2021

D type cyclins associate with multiple protein kinases and the DNA replication and repair factor PCNA

1 reference

https://api.crossref.org/works/10.1016%2FS0531-5565%2897%2900086-7

7 January 2021

Tumor induction and tissue atrophy in mice lacking E2F-1

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https://api.crossref.org/works/10.1016%2FS0531-5565%2897%2900086-7

7 January 2021

Wild-type p53 mediates positive regulation of gene expression through a specific DNA sequence element

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https://api.crossref.org/works/10.1016%2FS0531-5565%2897%2900086-7

7 January 2021

10.1016/S0531-5565(97)00086-7

Identifiers

DOI

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7 October 2017

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