Slowing of axonal transport is a very early event in the toxicity of ALS-linked SOD1 mutants to motor neurons (Q41644415)

6 October 2017

title

Slowing of axonal transport is a very early event in the toxicity of ALS-linked SOD1 mutants to motor neurons (English)

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amyotrophic lateral sclerosis

6 October 2017

main subject

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ORCID Public Data File 2021

author name string

T L Williamson

series ordinal

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6 October 2017

D W Cleveland

series ordinal

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6 October 2017

language of work or name

English

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publication date

1 January 1999

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6 October 2017

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6 October 2017

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6 October 2017

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6 October 2017

page(s)

50-56

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Mutations in Cu/Zn superoxide dismutase gene are associated with familial amyotrophic lateral sclerosis

6 October 2017

cites work

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7 January 2021

Amyotrophic lateral sclerosis and structural defects in Cu,Zn superoxide dismutase

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7 January 2021

Superoxide radical and superoxide dismutases

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7 January 2021

Free radicals, antioxidants, and human disease: curiosity, cause, or consequence?

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7 January 2021

Cellular defenses against damage from reactive oxygen species

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7 January 2021

Superoxide dismutase activity, oxidative damage, and mitochondrial energy metabolism in familial and sporadic amyotrophic lateral sclerosis

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7 January 2021

Superoxide dismutase 1 with mutations linked to familial amyotrophic lateral sclerosis possesses significant activity

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7 January 2021

Toxic mutants in Charcot's sclerosis

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7 January 2021

Motor neurons in Cu/Zn superoxide dismutase-deficient mice develop normally but exhibit enhanced cell death after axonal injury

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7 January 2021

Motor neuron degeneration in mice that express a human Cu,Zn superoxide dismutase mutation

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7 January 2021

An adverse property of a familial ALS-linked SOD1 mutation causes motor neuron disease characterized by vacuolar degeneration of mitochondria

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7 January 2021

Transgenic mice expressing an altered murine superoxide dismutase gene provide an animal model of amyotrophic lateral sclerosis

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7 January 2021

ALS-linked SOD1 mutant G85R mediates damage to astrocytes and promotes rapidly progressive disease with SOD1-containing inclusions.

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7 January 2021

Aggregation and Motor Neuron Toxicity of an ALS-Linked SOD1 Mutant Independent from Wild-Type SOD1

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7 January 2021

Absence of neurofilaments reduces the selective vulnerability of motor neurons and slows disease caused by a familial amyotrophic lateral sclerosis-linked superoxide dismutase 1 mutant

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7 January 2021

Fine structural study of neurofibrillary changes in a family with amyotrophic lateral sclerosis

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7 January 2021

Intense superoxide dismutase-1 immunoreactivity in intracytoplasmic hyaline inclusions of familial amyotrophic lateral sclerosis with posterior column involvement

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7 January 2021

SOD1 mutation is associated with accumulation of neurofilaments in amyotrophic lateral sclerosis.

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7 January 2021

Morphometric Comparison of the Vulnerability of Peripheral Motor and Sensory Neurons in Amyotrophic Lateral Sclerosis

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7 January 2021

Modulations of neurofilament axonal transport during the development of rabbit retinal ganglion cells

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7 January 2021

Progressive neuronopathy in transgenic mice expressing the human neurofilament heavy gene: a mouse model of amyotrophic lateral sclerosis

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7 January 2021

Defective axonal transport in a transgenic mouse model of amyotrophic lateral sclerosis

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7 January 2021

The slow component of axonal transport. Identification of major structural polypeptides of the axon and their generality among mammalian neurons

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7 January 2021

The mechanisms of fast and slow transport in neurons: identification and characterization of the new kinesin superfamily motors

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7 January 2021

Microtubules and axonal growth

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7 January 2021

Posttranslational modification of class III beta-tubulin

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7 January 2021

In vivo microtubules are copolymers of available beta-tubulin isotypes: localization of each of six vertebrate beta-tubulin isotypes using polyclonal antibodies elicited by synthetic peptide antigens

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7 January 2021

Axonal transport of mutant superoxide dismutase 1 and focal axonal abnormalities in the proximal axons of transgenic mice.

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7 January 2021

Retardation of fast axonal transport in wobbler mice

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7 January 2021

Neurofilaments and orthograde transport are reduced in ventral root axons of transgenic mice that express human SOD1 with a G93A mutation

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7 January 2021

Neurofilament subunit NF-H modulates axonal diameter by selectively slowing neurofilament transport

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7 January 2021

A mutant neurofilament subunit causes massive, selective motor neuron death: implications for the pathogenesis of human motor neuron disease

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7 January 2021

Slowing of the axonal transport of neurofilament proteins during development

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7 January 2021

Slowing of neurofilament transport and the radial growth of developing nerve fibers

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7 January 2021

Changes in neurofilament transport coincide temporally with alterations in the caliber of axons in regenerating motor fibers

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7 January 2021

Protective effect of neurofilament heavy gene overexpression in motor neuron disease induced by mutant superoxide dismutase

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7 January 2021

Chaperone-facilitated copper binding is a property common to several classes of familial amyotrophic lateral sclerosis-linked superoxide dismutase mutants

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7 January 2021

Increased expression of neurofilament subunit NF-L produces morphological alterations that resemble the pathology of human motor neuron disease

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7 January 2021

Superoxide dismutase is an abundant component in cell bodies, dendrites, and axons of motor neurons and in a subset of other neurons

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7 January 2021

Identifiers

DOI

10.1038/4553

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Dimensions Publication ID

6 October 2017

1037355746

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