Endothelial activation and apoptosis mediated by neutrophil-dependent interleukin 6 trans-signalling: a novel target for systemic sclerosis? (Q41614290)

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scientific article published on 10 November 2010

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English	Endothelial activation and apoptosis mediated by neutrophil-dependent interleukin 6 trans-signalling: a novel target for systemic sclerosis?	scientific article published on 10 November 2010

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scholarly article

1 reference

Europe PubMed Central

PMC publication ID

5 October 2017

Endothelial activation and apoptosis mediated by neutrophil-dependent interleukin 6 trans-signalling: a novel target for systemic sclerosis? (English)

1 reference

Europe PubMed Central

PMC publication ID

5 October 2017

0 references

2

1 reference

Europe PubMed Central

PMC publication ID

5 October 2017

author name string

Theresa C Barnes

1

1 reference

Europe PubMed Central

PMC publication ID

5 October 2017

Marina E Anderson

3

1 reference

Europe PubMed Central

PMC publication ID

5 October 2017

Steven W Edwards

4

1 reference

Europe PubMed Central

PMC publication ID

5 October 2017

Robert J Moots

5

1 reference

Europe PubMed Central

PMC publication ID

5 October 2017

language of work or name

0 references

publication date

10 November 2010

1 reference

Europe PubMed Central

PMC publication ID

5 October 2017

Annals of the Rheumatic Diseases

1 reference

Europe PubMed Central

PMC publication ID

5 October 2017

70

1 reference

Europe PubMed Central

PMC publication ID

5 October 2017

2

1 reference

Europe PubMed Central

PMC publication ID

5 October 2017

366-372

1 reference

Europe PubMed Central

PMC publication ID

5 October 2017

The pronounced Th17 profile in systemic sclerosis (SSc) together with intracellular expression of TGFbeta and IFNgamma distinguishes SSc phenotypes

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3015068

6 June 2018

The pathology of scleroderma vascular disease

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3015068

6 June 2018

IL-6 transsignaling: the in vivo consequences

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3015068

6 June 2018

Alterations of mononuclear inflammatory cells, CD4/CD8+ T cells, interleukin 1beta, and tumour necrosis factor alpha in the bronchoalveolar lavage fluid, peripheral blood, and skin of patients with systemic sclerosis

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3015068

6 June 2018

Of mice and not men: differences between mouse and human immunology

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3015068

6 June 2018

Interplay between IFN-gamma and IL-6 signaling governs neutrophil trafficking and apoptosis during acute inflammation

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3015068

6 June 2018

The role of soluble receptors in cytokine biology: the agonistic properties of the sIL-6R/IL-6 complex

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3015068

6 June 2018

Criteria for the classification of early systemic sclerosis.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3015068

6 June 2018

Endothelial injury in internal organs of University of California at Davis line 200 (UCD 200) chickens, an animal model for systemic sclerosis (Scleroderma).

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3015068

6 June 2018

Endogenous IL-1alpha from systemic sclerosis fibroblasts induces IL-6 and PDGF-A.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3015068

6 June 2018

Increased production of interleukin 6 and interleukin 8 in scleroderma fibroblasts.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3015068

6 June 2018

Scleroderma--demographics and survival

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3015068

6 June 2018

Role of IL-6 and its soluble receptor in induction of chemokines and leukocyte recruitment.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3015068

6 June 2018

Von Willebrand factor, thrombomodulin, thromboxane, beta-thromboglobulin and markers of fibrinolysis in primary Raynaud's phenomenon and systemic sclerosis

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3015068

6 June 2018

Endothelial cell apoptosis is a primary pathogenetic event underlying skin lesions in avian and human scleroderma

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3015068

6 June 2018

The soluble interleukin-6 receptor is generated by shedding

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3015068

6 June 2018

Soluble interleukin-6 receptors released from T cell or granulocyte/macrophage cell lines and human peripheral blood mononuclear cells are generated through an alternative splicing mechanism

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3015068

6 June 2018

Regulation of interleukin 6 receptor expression in human monocytes and monocyte-derived macrophages. Comparison with the expression in human hepatocytes

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3015068

6 June 2018

Isolation of an mRNA encoding a soluble form of the human interleukin-6 receptor

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3015068

6 June 2018

Protein kinase C activity is rate limiting for shedding of the interleukin-6 receptor.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3015068

6 June 2018

Neutrophil respiratory burst is decreased in scleroderma and normalized by near-infrared mediated hyperthermia.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3015068

19 August 2018

Longitudinal analysis of serum cytokine concentrations in systemic sclerosis: association of interleukin 12 elevation with spontaneous regression of skin sclerosis.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3015068

19 August 2018

Cyclooxygenase- and lipoxygenase-derived eicosanoids in bronchoalveolar lavage fluid from patients with scleroderma lung disease: an imbalance between proinflammatory and antiinflammatory lipid mediators.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3015068

19 August 2018

Chemotactic agents induce IL-6Ralpha shedding from polymorphonuclear cells: involvement of a metalloproteinase of the TNF-alpha-converting enzyme (TACE) type

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3015068

19 August 2018

Spontaneous neutrophil activation in patients with primary Raynaud's phenomenon and systemic sclerosis

1 reference

https://pubmed.ncbi.nlm.nih.gov/21068092

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Demonstration of interleukin 8 and autoantibodies to interleukin 8 in the serum of patients with systemic sclerosis and related disorders

1 reference

https://pubmed.ncbi.nlm.nih.gov/21068092

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

In situ expression of cytokines and cellular adhesion molecules in the skin of patients with systemic sclerosis. Their role in early and late disease

1 reference

https://pubmed.ncbi.nlm.nih.gov/21068092

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Correlation of soluble adhesion molecules in the peripheral blood of scleroderma patients with their in situ expression and with disease activity

1 reference

https://pubmed.ncbi.nlm.nih.gov/21068092

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Elevated serum interleukin-6 levels associated with active disease in systemic connective tissue disorders.

1 reference

https://pubmed.ncbi.nlm.nih.gov/21068092

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Altered levels of soluble adhesion molecules in rheumatoid arthritis, vasculitis and systemic sclerosis

1 reference

https://pubmed.ncbi.nlm.nih.gov/21068092

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Concentrations and origins of soluble interleukin 6 receptor-alpha in serum and synovial fluid

1 reference

https://pubmed.ncbi.nlm.nih.gov/21068092

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Serum levels of interleukin 6 (IL-6), oncostatin M, soluble IL-6 receptor, and soluble gp130 in patients with systemic sclerosis

1 reference

https://pubmed.ncbi.nlm.nih.gov/21068092

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Enhanced production of interleukin-6 (IL-6), oncostatin M and soluble IL-6 receptor by cultured peripheral blood mononuclear cells from patients with systemic sclerosis

1 reference

https://pubmed.ncbi.nlm.nih.gov/21068092

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Apoptosis is a natural stimulus of IL6R shedding and contributes to the proinflammatory trans-signaling function of neutrophils

1 reference

https://pubmed.ncbi.nlm.nih.gov/21068092

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The relationship between plasma microparticles and disease manifestations in patients with systemic sclerosis

1 reference

https://pubmed.ncbi.nlm.nih.gov/21068092

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Transcription factor fos-related antigen-2 induces progressive peripheral vasculopathy in mice closely resembling human systemic sclerosis

1 reference

https://pubmed.ncbi.nlm.nih.gov/21068092

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Serum levels of soluble interleukin 6 receptor and soluble gp130 are elevated in patients with localized scleroderma

1 reference

https://pubmed.ncbi.nlm.nih.gov/21068092

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

IL-6 and Its Soluble Receptor Orchestrate a Temporal Switch in the Pattern of Leukocyte Recruitment Seen during Acute Inflammation

1 reference

https://pubmed.ncbi.nlm.nih.gov/21068092

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Serum levels of interleukin-6 and interleukin-10 correlate with total skin thickness score in patients with systemic sclerosis

1 reference

https://pubmed.ncbi.nlm.nih.gov/21068092

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Overexpression of monocyte chemoattractant protein 1 in systemic sclerosis: role of platelet-derived growth factor and effects on monocyte chemotaxis and collagen synthesis

1 reference

https://pubmed.ncbi.nlm.nih.gov/21068092

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

IL-6: a regulator of the transition from neutrophil to monocyte recruitment during inflammation

1 reference

https://pubmed.ncbi.nlm.nih.gov/21068092

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Serum concentrations of the CXC chemokines interleukin 8 and growth-regulated oncogene-alpha are elevated in patients with systemic sclerosis

1 reference

https://pubmed.ncbi.nlm.nih.gov/21068092

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

ENHANCED OXIDATIVE METABOLISM OF NEUTROPHILS FROM PATIENTS WITH SYSTEMIC SCLEROSIS

1 reference

https://pubmed.ncbi.nlm.nih.gov/21068092

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Mechanisms of pathogenesis in scleroderma. I. Overproduction of interleukin 6 by fibroblasts cultured from affected skin sites of patients with scleroderma

1 reference

https://pubmed.ncbi.nlm.nih.gov/21068092

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1136/ARD.2010.133587

1 reference

Europe PubMed Central

PMC publication ID

5 October 2017

PMC publication ID

1 reference

Europe PubMed Central

PMC publication ID

5 October 2017

PubMed publication ID

1 reference

Europe PubMed Central

PMC publication ID

5 October 2017

ResearchGate publication ID

0 references

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