Suppressor of Cytokine Signaling-3 Is a Glucagon-inducible Inhibitor of PKA Activity and Gluconeogenic Gene Expression in Hepatocytes (Q41466117)

1 October 2017

Suppressor of cytokine signaling-3 is a glucagon-inducible inhibitor of PKA activity and gluconeogenic gene expression in hepatocytes (English)

1 reference

1 October 2017

Suppressor of Cytokine Signaling-3 Is a Glucagon-inducible Inhibitor of PKA Activity and Gluconeogenic Gene Expression in Hepatocytes (English)

1 reference

https://api.crossref.org/works/10.1074/JBC.M110.159111

10 August 2024

Jean S. Campbell

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?resulttype=core&format=json&query=SRC%3AMED%20AND%20EXT_ID%3A20978125

10 August 2024

Allison M. Gaudy

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10 August 2024

Alicia H. Clementi

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10 August 2024

Alan V. Smrcka

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10 August 2024

Robert A. Mooney

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10 August 2024

language of work or name

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publication date

26 October 2010

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full work available at URL

1 October 2017

http://www.jbc.org/content/285/53/41356.full.pdf

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http://intl.jbc.org/cgi/content/abstract/285/53/41356

10 August 2024

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https://www.ncbi.nlm.nih.gov/pmc/articles/pmid/20978125/pdf/?tool=EBI

10 August 2024

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10 August 2024

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https://europepmc.org/articles/PMC3009861

10 August 2024

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10 August 2024

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https://doi.org/10.1074/jbc.m110.159111

10 August 2024

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https://api.elsevier.com/content/article/PII:S0021925819761195?httpAccept=text/xml

10 August 2024

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https://api.elsevier.com/content/article/PII:S0021925819761195?httpAccept=text/plain

10 August 2024

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https://api.crossref.org/works/10.1074/JBC.M110.159111

https://syndication.highwire.org/content/doi/10.1074/jbc.M110.159111

10 August 2024

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https://api.crossref.org/works/10.1074/JBC.M110.159111

Journal of Biological Chemistry

10 August 2024

published in

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1 October 2017

285

1 reference

1 October 2017

1 reference

1 October 2017

41356-41365

1 reference

Activation of protein kinase Calpha by EPAC1 is required for the ERK- and CCAAT/enhancer-binding protein beta-dependent induction of the SOCS-3 gene by cyclic AMP in COS1 cells.

1 October 2017

1 reference

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A fasting inducible switch modulates gluconeogenesis via activator/coactivator exchange

11 June 2018

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The role of SOCS-3 protein in leptin resistance and obesity.

11 June 2018

1 reference

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Regulation of liver regeneration and hepatocarcinogenesis by suppressor of cytokine signaling 3

11 June 2018

1 reference

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Chronic tumor necrosis factor-alpha treatment causes insulin resistance via insulin receptor substrate-1 serine phosphorylation and suppressor of cytokine signaling-3 induction in 3T3-L1 adipocytes

11 June 2018

1 reference

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Cell physiology of cAMP sensor Epac

11 June 2018

1 reference

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Exchange protein activated by cyclic AMP (Epac)-mediated induction of suppressor of cytokine signaling 3 (SOCS-3) in vascular endothelial cells

11 June 2018

1 reference

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Dynamics of signaling by PKA.

11 June 2018

1 reference

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Interleukin-6 depletion selectively improves hepatic insulin action in obesity

11 June 2018

1 reference

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A-kinase-interacting protein localizes protein kinase A in the nucleus

11 June 2018

1 reference

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Central role of suppressors of cytokine signaling proteins in hepatic steatosis, insulin resistance, and the metabolic syndrome in the mouse

11 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3009861

Suppressor of cytokine signaling 1 (SOCS-1) and SOCS-3 cause insulin resistance through inhibition of tyrosine phosphorylation of insulin receptor substrate proteins by discrete mechanisms

11 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3009861

PKA: a portrait of protein kinase dynamics

11 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3009861

Insulin-regulated hepatic gluconeogenesis through FOXO1-PGC-1alpha interaction

11 June 2018

1 reference

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Glucagon and regulation of glucose metabolism

11 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3009861

Suppressor of cytokine signaling-3 (SOCS-3), a potential mediator of interleukin-6-dependent insulin resistance in hepatocytes.

11 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3009861

Interleukin-6 induces cellular insulin resistance in hepatocytes

11 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3009861

Phosphorylation of the catalytic subunit of protein kinase A. Autophosphorylation versus phosphorylation by phosphoinositide-dependent kinase-1.

11 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3009861

Intracellular targeting of the type-I alpha regulatory subunit of cAMP-dependent protein kinase

11 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3009861

SOCS-1 and SOCS-3 block insulin signaling by ubiquitin-mediated degradation of IRS1 and IRS2

11 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3009861

AKAP mediated signal transduction

11 June 2018

1 reference

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A new phospholipase-C-calcium signalling pathway mediated by cyclic AMP and a Rap GTPase

11 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3009861

Characterization of the gene EPAC2: structure, chromosomal localization, tissue expression, and identification of the liver-specific isoform

11 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3009861

SOCS-3 inhibits insulin signaling and is up-regulated in response to tumor necrosis factor-alpha in the adipose tissue of obese mice

11 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3009861

Calcium regulation of neuronal gene expression

11 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3009861

CREB regulates hepatic gluconeogenesis through the coactivator PGC-1

11 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3009861

Control of hepatic gluconeogenesis through the transcriptional coactivator PGC-1

11 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3009861

Regulation of insulin/insulin-like growth factor-1 signaling by proteasome-mediated degradation of insulin receptor substrate-2.

11 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3009861

Transcriptional regulation by the phosphorylation-dependent factor CREB

11 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3009861

Adipose tissue tumor necrosis factor and interleukin-6 expression in human obesity and insulin resistance

11 June 2018

2 references

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11 June 2018

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3009861

Insulin/IGF-1 and TNF-alpha stimulate phosphorylation of IRS-1 at inhibitory Ser307 via distinct pathways

30 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3009861

SOCS-3 is an insulin-induced negative regulator of insulin signaling

11 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3009861

A-kinase anchoring proteins: protein kinase A and beyond

11 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3009861

Effects of cAMP on ERK mitogen-activated protein kinase activity in hepatocytes do not parallel the bidirectional regulation of DNA synthesis

11 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3009861

The conserved SOCS box motif in suppressors of cytokine signaling binds to elongins B and C and may couple bound proteins to proteasomal degradation

11 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3009861

The Elongin BC complex interacts with the conserved SOCS-box motif present in members of the SOCS, ras, WD-40 repeat, and ankyrin repeat families

11 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3009861

A family of cAMP-binding proteins that directly activate Rap1

11 June 2018

1 reference

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SOCS: suppressors of cytokine signalling

11 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3009861

Phosphorylation and activation of cAMP-dependent protein kinase by phosphoinositide-dependent protein kinase

11 June 2018

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Growth hormone preferentially induces the rapid, transient expression of SOCS-3, a novel inhibitor of cytokine receptor signaling

11 June 2018

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Subcutaneous Adipose Tissue Releases Interleukin-6, But Not Tumor Necrosis Factor-α,in Vivo1

11 June 2018

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A molecular basis for insulin resistance. Elevated serine/threonine phosphorylation of IRS-1 and IRS-2 inhibits their binding to the juxtamembrane region of the insulin receptor and impairs their ability to undergo insulin-induced tyrosine phosphory

11 June 2018

1 reference

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IRS-1-mediated inhibition of insulin receptor tyrosine kinase activity in TNF-alpha- and obesity-induced insulin resistance

11 June 2018

1 reference

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Phosphorylated CREB binds specifically to the nuclear protein CBP

11 June 2018

1 reference

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Nuclear protein phosphatase 2A dephosphorylates protein kinase A-phosphorylated CREB and regulates CREB transcriptional stimulation

11 June 2018

1 reference

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Activation of cAMP and mitogen responsive genes relies on a common nuclear factor

11 June 2018

1 reference

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The molecular cloning of a type II regulatory subunit of the cAMP-dependent protein kinase from rat skeletal muscle and mouse brain

11 June 2018

1 reference

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Cyclic AMP stimulates somatostatin gene transcription by phosphorylation of CREB at serine 133

11 June 2018

1 reference

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Molecular physiology of the regulation of hepatic gluconeogenesis and glycolysis

11 June 2018

1 reference

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Phosphorylation of CREB affects its binding to high and low affinity sites: implications for cAMP induced gene transcription

11 June 2018

1 reference

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Transcriptional attenuation following cAMP induction requires PP-1-mediated dephosphorylation of CREB.

11 June 2018

1 reference

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Selective inhibition of cytokine-activated extracellular signal-regulated kinase by cyclic AMP via Epac1-dependent induction of suppressor of cytokine signalling-3.

11 June 2018

1 reference

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Identification of CCAAT/enhancer-binding proteins as exchange protein activated by cAMP-activated transcription factors that mediate the induction of the SOCS-3 gene.

19 August 2018

1 reference

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The dual function of hepatic SOCS3 in insulin resistance in vivo.

19 August 2018

1 reference

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Phospholipase C epsilon modulates beta-adrenergic receptor-dependent cardiac contraction and inhibits cardiac hypertrophy

19 August 2018

1 reference

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Epac: a new cAMP target and new avenues in cAMP research

19 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3009861

The role of leptin resistance in the lipid abnormalities of aging

19 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3009861

Insulin-induced insulin receptor substrate-1 degradation is mediated by the proteasome degradation pathway.

19 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3009861

Tissue distribution of rat glucagon receptor and GLP-1 receptor gene expression1This work was supported by a grant from the Crohn's and Colitis Foundation of America.1

19 August 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M110.159111

Starvation in the rat. II. Effect of age and obesity on protein sparing and fuel metabolism

21 January 2018

1 reference

12 December 2020

Direct and indirect effects of insulin in suppressing glucose production in depancreatized dogs: role of glucagon

1 reference

12 December 2020

Glucagon enhances the direct suppressive effect of insulin on hepatic glucose production in humans

1 reference

12 December 2020

Glucagon activates Ca2+ and Cl- channels in rat hepatocytes

1 reference

12 December 2020

Epac-mediated activation of phospholipase C(epsilon) plays a critical role in beta-adrenergic receptor-dependent enhancement of Ca2+ mobilization in cardiac myocytes

1 reference

12 December 2020

American Journal of Physiology

239

E277

Goodman

1980

1 reference

https://api.crossref.org/works/10.1074/JBC.M110.159111

The Journal of Clinical Endocrinology and Metabolism

10 August 2024

4196

Mohamed-Ali

1997

1 reference

https://api.crossref.org/works/10.1074/JBC.M110.159111

American Journal of Physiology

10 August 2024

272

E371

Lewis

1997

1 reference

https://api.crossref.org/works/10.1074/JBC.M110.159111

10 August 2024

Identifiers

1 reference

1 October 2017

1 reference

1 October 2017

1 reference