Renal uptake of the antiapoptotic protein survivin is mediated by megalin at the apical membrane of the proximal tubule. (Q41412746)

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4 March 2020

title

Renal uptake of the antiapoptotic protein survivin is mediated by megalin at the apical membrane of the proximal tubule (English)

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LDL receptor related protein 2

4 March 2020

main subject

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GOA release 2020-03-11

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4 March 2020

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4 March 2020

Kai-Uwe Eckardt

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4 March 2020

Karl X Knaup

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4 March 2020

Thomas Hackenbeck

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4 March 2020

Maike Buettner-Herold

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Philipp Lechler

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4 March 2020

Sven Kroening

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4 March 2020

Margarethe Goppelt-Struebe

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4 March 2020

Ursula Schloetzer-Schrehardt

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4 March 2020

Barbara G Fürnrohr

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4 March 2020

Reinhard E Voll

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4 March 2020

Kerstin Amann

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Erik I Christensen

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Michael S Wiesener

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publication date

3 July 2013

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American Journal of Physiology - Renal Physiology

4 March 2020

published in

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volume

305

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issue

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page(s)

F734-44

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Survivin and IAP proteins in cell-death mechanisms

4 March 2020

cites work

1 reference

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Characterization of an epithelial approximately 460-kDa protein that facilitates endocytosis of intrinsic factor-vitamin B12 and binds receptor-associated protein

21 January 2018

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Receptor-mediated endocytosis in renal proximal tubule

21 January 2018

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Mutations in LRP2, which encodes the multiligand receptor megalin, cause Donnai-Barrow and facio-oculo-acoustico-renal syndromes

21 January 2018

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Survivin is released from cancer cells via exosomes.

21 January 2018

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Protective role of the inhibitor of apoptosis protein, survivin, in toxin-induced acute renal failure

21 January 2018

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Characterization of connective tissue growth factor expression in primary cultures of human tubular epithelial cells: modulation by hypoxia

21 January 2018

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The tumor gene survivin is highly expressed in adult renal tubular cells: implications for a pathophysiological role in the kidney

21 January 2018

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beta2-glycoprotein-I (apolipoprotein H) and beta2-glycoprotein-I-phospholipid complex harbor a recognition site for the endocytic receptor megalin

21 January 2018

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Enhanced apoptotic cell death of renal epithelial cells in mice lacking transcription factor AP-2β

21 January 2018

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An endocytic pathway essential for renal uptake and activation of the steroid 25-(OH) vitamin D3

21 January 2018

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Cubilin dysfunction causes abnormal metabolism of the steroid hormone 25(OH) vitamin D(3)

21 January 2018

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Targeting apoptosis in acute tubular injury

21 January 2018

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Phase I study of YM155, a novel survivin suppressant, in patients with advanced solid tumors

21 January 2018

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Renal phenotypic investigations of megalin-deficient patients: novel insights into tubular proteinuria and albumin filtration

21 January 2018

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A phase II study of YM155, a novel small-molecule suppressor of survivin, in castration-resistant taxane-pretreated prostate cancer

21 January 2018

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Bcl-2-deficient mice demonstrate fulminant lymphoid apoptosis, polycystic kidneys, and hypopigmented hair

21 January 2018

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Structural basis for phosphoserine-proline recognition by group IV WW domains

21 January 2018

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Mouse model of proximal tubule endocytic dysfunction.

21 January 2018

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Defective forebrain development in mice lacking gp330/megalin

21 January 2018

1 reference

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