Targeted deletion of the extracellular signal-regulated protein kinase 5 attenuates hypertrophic response and promotes pressure overload-induced apoptosis in the heart (Q41205020)

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scientific article published on 14 January 2010

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English	Targeted deletion of the extracellular signal-regulated protein kinase 5 attenuates hypertrophic response and promotes pressure overload-induced apoptosis in the heart	scientific article published on 14 January 2010

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scholarly article

1 reference

Europe PubMed Central

PMC publication ID

28 September 2017

Targeted deletion of the extracellular signal-regulated protein kinase 5 attenuates hypertrophic response and promotes pressure overload-induced apoptosis in the heart (English)

1 reference

Europe PubMed Central

PMC publication ID

28 September 2017

6

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Europe PubMed Central

PMC publication ID

28 September 2017

4

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author name string

Tomomi E Kimura

1

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Europe PubMed Central

PMC publication ID

28 September 2017

Jiawei Jin

2

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Europe PubMed Central

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28 September 2017

Min Zi

3

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Europe PubMed Central

PMC publication ID

28 September 2017

Sukhpal Prehar

4

1 reference

Europe PubMed Central

PMC publication ID

28 September 2017

Wei Liu

5

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Europe PubMed Central

PMC publication ID

28 September 2017

Jun-ichi Abe

7

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Europe PubMed Central

PMC publication ID

28 September 2017

Ludwig Neyses

8

1 reference

Europe PubMed Central

PMC publication ID

28 September 2017

Arthur H Weston

9

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Europe PubMed Central

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28 September 2017

Elizabeth J Cartwright

10

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Europe PubMed Central

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28 September 2017

Xin Wang

11

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Europe PubMed Central

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28 September 2017

language of work or name

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publication date

14 January 2010

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Europe PubMed Central

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28 September 2017

Circulation Research

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Europe PubMed Central

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28 September 2017

106

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Europe PubMed Central

PMC publication ID

28 September 2017

5

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Europe PubMed Central

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28 September 2017

961-970

1 reference

Europe PubMed Central

PMC publication ID

28 September 2017

miR-133 and miR-30 regulate connective tissue growth factor: implications for a role of microRNAs in myocardial matrix remodeling

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3003662

28 September 2017

Identification of pharmacological inhibitors of the MEK5/ERK5 pathway

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3003662

28 September 2017

Fluid shear stress inhibits TNF-mediated JNK activation via MEK5-BMK1 in endothelial cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3003662

28 September 2017

The MEF2D transcription factor mediates stress-dependent cardiac remodeling in mice

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3003662

28 September 2017

Mitogen-activated protein kinases in heart development and diseases

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3003662

28 September 2017

p53 and Bad: remote strangers become close friends

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3003662

28 September 2017

The Bad guy cooperates with good cop p53: Bad is transcriptionally up-regulated by p53 and forms a Bad/p53 complex at the mitochondria to induce apoptosis

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3003662

28 September 2017

Regulation of cellular functions by the ERK5 signalling pathway

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3003662

28 September 2017

A novel mitogen-activated protein kinase docking site in the N terminus of MEK5alpha organizes the components of the extracellular signal-regulated kinase 5 signaling pathway.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3003662

28 September 2017

Death begets failure in the heart

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3003662

28 September 2017

Targeted deletion of mek5 causes early embryonic death and defects in the extracellular signal-regulated kinase 5/myocyte enhancer factor 2 cell survival pathway

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3003662

28 September 2017

p38alpha mitogen-activated protein kinase plays a critical role in cardiomyocyte survival but not in cardiac hypertrophic growth in response to pressure overload.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3003662

28 September 2017

Targeted deletion of BMK1/ERK5 in adult mice perturbs vascular integrity and leads to endothelial failure.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3003662

28 September 2017

Differential Role of MEK5α and MEK5β in BMK1/ERK5 Activation

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3003662

28 September 2017

Activation of gp130 transduces hypertrophic signal through interaction of scaffolding/docking protein Gab1 with tyrosine phosphatase SHP2 in cardiomyocytes

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3003662

28 September 2017

Roles of cardiac transcription factors in cardiac hypertrophy

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3003662

28 September 2017

Targeted inhibition of p38 MAPK promotes hypertrophic cardiomyopathy through upregulation of calcineurin-NFAT signaling

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3003662

28 September 2017

Load-induced transcriptional activation of c-jun in rat myocardium: regulation by myocyte enhancer factor 2.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3003662

28 September 2017

Akt/protein kinase B promotes organ growth in transgenic mice

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3003662

28 September 2017

Activated MEK5 induces serial assembly of sarcomeres and eccentric cardiac hypertrophy.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3003662

28 September 2017

ERK5 is a novel type of mitogen-activated protein kinase containing a transcriptional activation domain

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3003662

28 September 2017

Mutational analysis of the DNA binding, dimerization, and transcriptional activation domains of MEF2C

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3003662

28 September 2017

Isolation of MEK5 and differential expression of alternatively spliced forms

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3003662

28 September 2017

Cardiomyocyte-specific inactivation of transcription factor CREB in mice.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3003662

17 June 2018

Activation of extracellular signal-regulated kinase 5 reduces cardiac apoptosis and dysfunction via inhibition of a phosphodiesterase 3A/inducible cAMP early repressor feedback loop

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3003662

17 June 2018

Regulation of nuclear translocation of extracellular signal-regulated kinase 5 by active nuclear import and export mechanisms.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3003662

17 June 2018

CTGF expression is induced by TGF- beta in cardiac fibroblasts and cardiac myocytes: a potential role in heart fibrosis

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3003662

17 June 2018

Cardiac-specific deletion of mkk4 reveals its role in pathological hypertrophic remodeling but not in physiological cardiac growth.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3003662

19 August 2018

Regulation of neuronal survival by the extracellular signal-regulated protein kinase 5.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3003662

19 August 2018

A new type of ERK1/2 autophosphorylation causes cardiac hypertrophy

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3003662

19 August 2018

Big mitogen-activated protein kinase 1/extracellular signal-regulated kinase 5 signaling pathway is essential for tumor-associated angiogenesis

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3003662

19 August 2018

Activation of big MAP kinase 1 (BMK1/ERK5) inhibits cardiac injury after myocardial ischemia and reperfusion

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3003662

19 August 2018

Big mitogen-activated protein kinase (BMK1)/ERK5 protects endothelial cells from apoptosis

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3003662

19 August 2018

Activation of mitogen-activated protein kinases and p90 ribosomal S6 kinase in failing human hearts with dilated cardiomyopathy

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3003662

19 August 2018

p53-induced inhibition of Hif-1 causes cardiac dysfunction during pressure overload

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3003662

2 December 2018

Myocyte Enhancer Factors 2A and 2C Induce Dilated Cardiomyopathy in Transgenic Mice

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3003662

2 December 2018

Alterations in G protein and MAP kinase signaling pathways during cardiac remodeling in hypertension and heart failure

1 reference

https://pubmed.ncbi.nlm.nih.gov/20075332

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Cellular mechanisms of cardiac hypertrophy

1 reference

https://pubmed.ncbi.nlm.nih.gov/20075332

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

MEF2 activates a genetic program promoting chamber dilation and contractile dysfunction in calcineurin-induced heart failure

1 reference

https://pubmed.ncbi.nlm.nih.gov/20075332

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1161/CIRCRESAHA.109.209320

1 reference

Europe PubMed Central

PMC publication ID

28 September 2017

PMC publication ID

1 reference

Europe PubMed Central

PMC publication ID

28 September 2017

PubMed publication ID

1 reference

Europe PubMed Central

PMC publication ID

28 September 2017

ResearchGate publication ID

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