Arachidonate 5-lipoxygenase (Q411791)

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mammalian protein found in Homo sapiens

ALOX5
arachidonate 5-lipoxygenase
arachidonic acid 5-lipoxygenase
LOX-5
arachidonic 5-lipoxygenase delta-13 isoform
uniprot:P09917
arachidonic 5-lipoxygenase delta-p10 isoform
arachidonic 5-lipoxygenase delta-10-13 isoform
arachidonic 5-lipoxygenase alpha-10 isoform
leukotriene A4 synthase
ALOX5 protein, human

Language	Label	Description	Also known as
English	Arachidonate 5-lipoxygenase	mammalian protein found in Homo sapiens	ALOX5 arachidonate 5-lipoxygenase arachidonic acid 5-lipoxygenase LOX-5 arachidonic 5-lipoxygenase delta-13 isoform uniprot:P09917 arachidonic 5-lipoxygenase delta-p10 isoform arachidonic 5-lipoxygenase delta-10-13 isoform arachidonic 5-lipoxygenase alpha-10 isoform leukotriene A4 synthase ALOX5 protein, human

Statements

1 reference

13 November 2019

UniProt protein ID

Lipoxigenase, C-terminal domain superfamily

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/P09917

PLAT/LH2 domain superfamily

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/P09917

Lipoxygenase, mammalian

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/P09917

Lipoxygenase, C-terminal domain, protein family

1 reference

based on heuristic

inferred from protein domain or family

Lipoxygenase, iron binding site, protein family

1 reference

based on heuristic

inferred from protein domain or family

PLAT/LH2 domain, protein family

1 reference

based on heuristic

inferred from protein domain or family

Lipoxygenase, conserved site, protein family

1 reference

based on heuristic

inferred from protein domain or family

1 reference

13 November 2019

UniProt protein ID

1 reference

13 November 2019

UniProt protein ID

molecular function

arachidonate 5-lipoxygenase activity

determination method or standard

4 references

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P09917

determination method or standard

8 April 2019

Molecular cloning and amino acid sequence of human 5-lipoxygenase

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P09917

determination method or standard

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P09917

determination method or standard

8 April 2019

The structure of human 5-lipoxygenase

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P09917

determination method or standard

dioxygenase activity

determination method or standard

1 reference

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P09917

determination method or standard

protein binding

determination method or standard

8 references

8 April 2019

Distinct parts of leukotriene C(4) synthase interact with 5-lipoxygenase and 5-lipoxygenase activating protein

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P09917

determination method or standard

8 April 2019

Molecular cloning and functional characterization of mouse coactosin-like protein

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P09917

determination method or standard

8 April 2019

5-Lipoxygenase interacts with coactosin-like protein

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P09917

determination method or standard

8 April 2019

Coactosin-like protein supports 5-lipoxygenase enzyme activity and up-regulates leukotriene A4 production

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P09917

determination method or standard

8 April 2019

5-Lipoxygenase interacts with coactosin-like protein

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P09917

determination method or standard

8 April 2019

Analysis of 5-lipoxygenase phosphorylation on molecular level by MALDI-MS

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P09917

determination method or standard

8 April 2019

A proteome-scale map of the human interactome network

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P09917

determination method or standard

8 April 2019

Widespread macromolecular interaction perturbations in human genetic disorders

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P09917

determination method or standard

oxidoreductase activity

determination method or standard

1 reference

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P09917

determination method or standard

oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen

determination method or standard

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P09917

determination method or standard

determination method or standard

1 reference

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P09917

determination method or standard

nuclear envelope lumen

determination method or standard

1 reference

8 April 2019

5-lipoxygenase and 5-lipoxygenase-activating protein are localized in the nuclear envelope of activated human leukocytes

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P09917

determination method or standard

extracellular region

determination method or standard

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P09917

determination method or standard

extracellular space

determination method or standard

1 reference

17 October 2017

Comparison of tear protein levels in breast cancer patients and healthy controls using a de novo proteomic approach

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=P09917&geneProductId=UniProtKB:P09917

determination method or standard

determination method or standard

1 reference

8 April 2019

Human Protein Atlas

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P09917

determination method or standard

secretory granule lumen

determination method or standard

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P09917

determination method or standard

ficolin-1-rich granule lumen

determination method or standard

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P09917

determination method or standard

extracellular space

determination method or standard

1 reference

8 April 2019

Comparison of tear protein levels in breast cancer patients and healthy controls using a de novo proteomic approach

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P09917

determination method or standard

biological process

leukotriene metabolic process

determination method or standard

leukotriene production involved in inflammatory response

determination method or standard

1 reference

8 April 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P09917

determination method or standard

leukotriene biosynthetic process

determination method or standard

3 references

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P09917

determination method or standard

8 April 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P09917

determination method or standard

8 April 2019

The structure of human 5-lipoxygenase

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P09917

determination method or standard

inflammatory response

determination method or standard

1 reference

8 April 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P09917

determination method or standard

lipoxin metabolic process

determination method or standard

1 reference

17 October 2017

http://www.ebi.ac.uk/QuickGO/annotations?protein=P09917&geneProductId=UniProtKB:P09917

determination method or standard

lipoxygenase pathway

determination method or standard

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P09917

determination method or standard

neutrophil degranulation

determination method or standard

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P09917

determination method or standard

cytokine-mediated signaling pathway

determination method or standard

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P09917

determination method or standard

interleukin-18-mediated signaling pathway

determination method or standard

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P09917

determination method or standard

long-chain fatty acid biosynthetic process

determination method or standard

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P09917

determination method or standard

lipoxin biosynthetic process

determination method or standard

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P09917

determination method or standard

physically interacts with

enzyme inhibitor

1 reference

IUPHAR/BPS Guide to PHARMACOLOGY

Guide to Pharmacology Ligand ID

language of work or name

17 August 2016

object of statement has role

reaction inhibitor

1 reference

Open Targets Platform

14 August 2023

https://platform.opentargets.org/drug/CHEMBL93

Gene Atlas image

PBB GE ALOX5 204446 s at fs.png
732 × 530; 11 KB

0 references

http://purl.uniprot.org/uniprot/P09917

1 reference

Identifiers.org

Identifiers

MeSH descriptor ID

subject named as

ALOX5 protein, human

0 references

RefSeq protein ID

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

UniProt protein ID

1 reference

13 November 2019

UniProt protein ID

Ensembl protein ID

ENSP00000363512

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000363512

ENSP00000437634

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000437634

ENSP00000479958

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000479958

ENSP00000484468

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000484468

ENSP00000479452

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000479452

ENSP00000483803

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000483803

1 reference

Freebase Data Dumps

publication date

28 October 2013

Microsoft Academic ID

0 references

PDB structure ID

1 reference

UniProt protein ID

4 August 2016

language of work or name

1 reference

UniProt protein ID

4 August 2016

language of work or name

1 reference

UniProt protein ID

4 August 2016

language of work or name

1 reference

UniProt protein ID

4 August 2016

language of work or name

1 reference

based on heuristic

inferred by common MeSH mappings on source and on Wikidata

25 May 2023

Sitelinks

Wikipedia(0 entries)

Wikibooks(0 entries)

Wikinews(0 entries)

Wikiquote(0 entries)

Wikisource(0 entries)

Wikiversity(0 entries)

Wikivoyage(0 entries)

Wiktionary(0 entries)

Multilingual sites(0 entries)

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