The hydrophilic isoform of glutamate decarboxylase, GAD67, is targeted to membranes and nerve terminals independent of dimerization with the hydrophobic membrane-anchored isoform, GAD65. (Q41166666)

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scientific article published on December 1999

Language	Label	Description	Also known as
English	The hydrophilic isoform of glutamate decarboxylase, GAD67, is targeted to membranes and nerve terminals independent of dimerization with the hydrophobic membrane-anchored isoform, GAD65.	scientific article published on December 1999

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scholarly article

1 reference

Europe PubMed Central

PubMed publication ID

27 September 2017

The hydrophilic isoform of glutamate decarboxylase, GAD67, is targeted to membranes and nerve terminals independent of dimerization with the hydrophobic membrane-anchored isoform, GAD65. (English)

1 reference

Europe PubMed Central

PubMed publication ID

27 September 2017

1 reference

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author name string

Kanaani J

1

1 reference

Europe PubMed Central

PubMed publication ID

27 September 2017

Lissin D

2

1 reference

Europe PubMed Central

PubMed publication ID

27 September 2017

Kash SF

3

1 reference

Europe PubMed Central

PubMed publication ID

27 September 2017

Baekkeskov S

4

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Europe PubMed Central

PubMed publication ID

27 September 2017

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publication date

1 December 1999

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Europe PubMed Central

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27 September 2017

Journal of Biological Chemistry

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27 September 2017

274

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Europe PubMed Central

PubMed publication ID

27 September 2017

52

1 reference

Europe PubMed Central

PubMed publication ID

27 September 2017

37200-37209

1 reference

Europe PubMed Central

PubMed publication ID

27 September 2017

Regulation of gamma-aminobutyric acid synthesis in the brain

1 reference

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21 January 2018

High Concentration of GABA and High Glutamate Decarboxylase Activity in Rat Pancreatic Islets and Human Insulinoma

1 reference

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21 January 2018

Two genes encode distinct glutamate decarboxylases

1 reference

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21 January 2018

Brain glutamate decarboxylase cloned in lambda gt-11: fusion protein produces gamma-aminobutyric acid

1 reference

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21 January 2018

Two human glutamate decarboxylases, 65-kDa GAD and 67-kDa GAD, are each encoded by a single gene

1 reference

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21 January 2018

Regional differences in cofactor saturation of glutamate decarboxylase (GAD) in discrete brain nuclei of the rat. Effect of repeated administration of haloperidol on GAD activity in the substantia nigra

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21 January 2018

Two forms of the gamma-aminobutyric acid synthetic enzyme glutamate decarboxylase have distinct intraneuronal distributions and cofactor interactions.

1 reference

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21 January 2018

Epilepsy in mice deficient in the 65-kDa isoform of glutamic acid decarboxylase

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21 January 2018

Identification of the 64K autoantigen in insulin-dependent diabetes as the GABA-synthesizing enzyme glutamic acid decarboxylase

1 reference

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21 January 2018

GAD-reactive CD4+ Th1 cells induce diabetes in NOD/SCID mice.

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Autoantibodies to GABA-ergic neurons and pancreatic beta cells in stiff-man syndrome

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21 January 2018

The structural and functional heterogeneity of glutamic acid decarboxylase: A review

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21 January 2018

Motifs and structural fold of the cofactor binding site of human glutamate decarboxylase

1 reference

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21 January 2018

Targeting of the 67-kDa isoform of glutamic acid decarboxylase to intracellular organelles is mediated by its interaction with the NH2-terminal region of the 65-kDa isoform of glutamic acid decarboxylase

1 reference

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21 January 2018

Membrane anchoring of the autoantigen GAD65 to microvesicles in pancreatic beta-cells by palmitoylation in the NH2-terminal domain

1 reference

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21 January 2018

Association of GAD-65, but not of GAD-67, with the Golgi complex of transfected Chinese hamster ovary cells mediated by the N-terminal region

1 reference

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21 January 2018

A signal located within amino acids 1-27 of GAD65 is required for its targeting to the Golgi complex region

1 reference

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21 January 2018

Phosphorylation of serine residues 3, 6, 10, and 13 distinguishes membrane anchored from soluble glutamic acid decarboxylase 65 and is restricted to glutamic acid decarboxylase 65alpha

1 reference

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21 January 2018

Amino acid residues 24-31 but not palmitoylation of cysteines 30 and 45 are required for membrane anchoring of glutamic acid decarboxylase, GAD65

1 reference

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21 January 2018

Differential expression of GAD65 and GAD67 in human, rat, and mouse pancreatic islets.

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21 January 2018

Autoreactive epitopes defined by diabetes-associated human monoclonal antibodies are localized in the middle and C-terminal domains of the smaller form of glutamate decarboxylase

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21 January 2018

Identification of a transmembrane glycoprotein specific for secretory vesicles of neural and endocrine cells.

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Optimized survival of hippocampal neurons in B27-supplemented Neurobasal, a new serum-free medium combination

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21 January 2018

Evidence for two distinct forms of native glutamic acid decarboxylase in rat brain soluble extract: an immunoblotting study

1 reference

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21 January 2018

Cleft palate and decreased brain gamma-aminobutyric acid in mice lacking the 67-kDa isoform of glutamic acid decarboxylase

1 reference

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21 January 2018

Cleft palate in mice with a targeted mutation in the γ-aminobutyric acid-producing enzyme glutamic acid decarboxylase 67

1 reference

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21 January 2018

Increased anxiety and altered responses to anxiolytics in mice deficient in the 65-kDa isoform of glutamic acid decarboxylase.

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21 January 2018

Local GABA circuit control of experience-dependent plasticity in developing visual cortex.

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21 January 2018

Identifiers

10.1074/JBC.274.52.37200

1 reference

Europe PubMed Central

PubMed publication ID

27 September 2017

PubMed publication ID

1 reference

Europe PubMed Central

PubMed publication ID

27 September 2017

ResearchGate publication ID

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