Impact of loss of NF-κB1, NF-κB2 or c-REL on SLE-like autoimmune disease and lymphadenopathy in Fas(lpr/lpr) mutant mice (Q41154690)

27 September 2017

title

Impact of loss of NF-κB1, NF-κB2 or c-REL on SLE-like autoimmune disease and lymphadenopathy in Fas(lpr/lpr) mutant mice (English)

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27 September 2017

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13 June 2020

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13 June 2020

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13 June 2020

J T Low

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13 June 2020

P Hughes

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13 June 2020

A Lin

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13 June 2020

U Siebenlist

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13 June 2020

K Yaprianto

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13 June 2020

S Gerondakis

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13 June 2020

L A O'Reilly

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13 June 2020

publication date

18 June 2015

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Immunology & Cell Biology

27 September 2017

published in

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13 June 2020

volume

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13 June 2020

issue

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13 June 2020

page(s)

66-78

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Molecular therapies for systemic lupus erythematosus: clinical trials and future prospects

13 June 2020

cites work

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BH3-only Bcl-2 family member Bim is required for apoptosis of autoreactive thymocytes

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Loss of the pro-apoptotic BH3-only Bcl-2 family member Bim inhibits BCR stimulation-induced apoptosis and deletion of autoreactive B cells

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Cellular and genetic mechanisms of self tolerance and autoimmunity

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The many roles of FAS receptor signaling in the immune system

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Membrane-bound Fas ligand only is essential for Fas-induced apoptosis

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Fas receptor expression in germinal-center B cells is essential for T and B lymphocyte homeostasis

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Unravelling the complexities of the NF-kappaB signalling pathway using mouse knockout and transgenic models.

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Immune deficiency or hyperactivity-Nf-kappab illuminates autoimmunity.

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NF-kappaB: a key role in inflammatory diseases

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Shared principles in NF-kappaB signaling

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Alternative and classical NF-kappa B signaling retain autoreactive B cells in the splenic marginal zone and result in lupus-like disease

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Chronic inflammation induces telomere dysfunction and accelerates ageing in mice.

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Targeted disruption of the p50 subunit of NF-kappa B leads to multifocal defects in immune responses

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NF-kappaB2 is required for the control of autoimmunity by regulating the development of medullary thymic epithelial cells

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Nuclear factor (NF)-kappa B2 (p100/p52) is required for normal splenic microarchitecture and B cell-mediated immune responses

21 January 2018

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Lpr and gld: single gene models of systemic autoimmunity and lymphoproliferative disease

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The classification of glomerulonephritis in systemic lupus erythematosus revisited

21 January 2018

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Loss of c-REL but not NF-κB2 prevents autoimmune disease driven by FasL mutation

21 January 2018

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Apoptosis regulators Fas and Bim cooperate in shutdown of chronic immune responses and prevention of autoimmunity

21 January 2018

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Mice deficient in nuclear factor (NF)-kappa B/p52 present with defects in humoral responses, germinal center reactions, and splenic microarchitecture

21 January 2018

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Systemic autoimmune disease induced by dendritic cells that have captured necrotic but not apoptotic cells in susceptible mouse strains.

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The role of leukocytes, keratinocytes, and allergen-specific IgE in the development of atopic dermatitis

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Foxp3+ cells control Th2 responses in a murine model of atopic dermatitis.

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c-Rel is required for the development of thymic Foxp3+ CD4 regulatory T cells

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Danger-free autoimmune disease in Aire-deficient mice

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NF-κB control of T cell development

21 January 2018

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Control of central self-tolerance induction by autoreactive CD4+ thymocytes

21 January 2018

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Minireview: Glucocorticoids in autoimmunity: unexpected targets and mechanisms

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IkappaB kinase inhibitors for treating autoimmune and inflammatory disorders: potential and challenges

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Modulation of nuclear factor-kappaB activity can influence the susceptibility to systemic lupus erythematosus

21 January 2018

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Regulation of naive T cell function by the NF-kappaB2 pathway

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Control of lymphocyte development by nuclear factor-kappaB.

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Germline mutations in NFKB2 implicate the noncanonical NF-κB pathway in the pathogenesis of common variable immunodeficiency

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Autosomal-dominant B-cell deficiency with alopecia due to a mutation in NFKB2 that results in nonprocessable p100.

21 January 2018

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Combined immune deficiency in a patient with a novel NFKB2 mutation

21 January 2018

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T cell-specific ablation of Fas leads to Fas ligand-mediated lymphocyte depletion and inflammatory pulmonary fibrosis

21 January 2018

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The NF-kappaB p50:p50:HDAC-1 repressor complex orchestrates transcriptional inhibition of multiple pro-inflammatory genes

21 January 2018

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The c-Rel Transcription Factor in Development and Disease

21 January 2018

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IgE, mast cells, and eosinophils in atopic dermatitis

21 January 2018

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Skin inflammation arising from cutaneous regulatory T cell deficiency leads to impaired viral immune responses.

21 January 2018

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A small-molecule c-Rel inhibitor reduces alloactivation of T cells without compromising antitumor activity

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The NF- B Transcription Factor c-Rel Is Required for Th17 Effector Cell Development in Experimental Autoimmune Encephalomyelitis

21 January 2018

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12 December 2020

The transcriptional regulator Rel is essential for antigen receptor-mediated stimulation of mature T cells but dispensable for positive and negative selection of thymocytes and T cell apoptosis

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12 December 2020

NF-kappaB/p50 and NF-kappaB/c-Rel differentially regulate the activity of the 3'alphaE-hsl,2 enhancer in normal murine B cells in an activation-dependent manner

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12 December 2020

Mice lacking the c-rel proto-oncogene exhibit defects in lymphocyte proliferation, humoral immunity, and interleukin-2 expression

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12 December 2020

Effect of renal disease on the standardized mortality ratio and life expectancy of patients with systemic lupus erythematosus

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12 December 2020

Induction of various autoantibodies by mutant gene lpr in several strains of mice

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12 December 2020

Association between the NFKB1-94ins/del ATTG polymorphism and cancer risk: an updated meta-analysis

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12 December 2020

Development of atopic dermatitis-like skin lesion with IgE hyperproduction in NC/Nga mice

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Inhibition of NF-kappaB in T cells blocks lymphoproliferation and partially rescues autoimmune disease in gld/gld mice

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12 December 2020

Identifiers

DOI

10.1038/ICB.2015.66

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26084385%20AND%20SRC:MED&resulttype=core&format=json

13 June 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26084385%20AND%20SRC:MED&resulttype=core&format=json