Rapid and transient recruitment of DNMT1 to DNA double-strand breaks is mediated by its interaction with multiple components of the DNA damage response machinery. (Q41122376)

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scientific article published on 11 October 2010

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English	Rapid and transient recruitment of DNMT1 to DNA double-strand breaks is mediated by its interaction with multiple components of the DNA damage response machinery.	scientific article published on 11 October 2010

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scholarly article

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15 February 2020

Rapid and transient recruitment of DNMT1 to DNA double-strand breaks is mediated by its interaction with multiple components of the DNA damage response machinery (English)

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15 February 2020

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15 February 2020

Keith D. Robertson

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15 February 2020

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Kyungsoo Ha

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15 February 2020

Gun Eui Lee

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15 February 2020

Stela S Palii

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Kevin D Brown

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15 February 2020

Yoshihiko Takeda

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15 February 2020

Kapil N Bhalla

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11 October 2010

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15 February 2020

Human Molecular Genetics

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15 February 2020

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15 February 2020

1

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15 February 2020

126-140

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15 February 2020

Disruption of Dnmt1/PCNA/UHRF1 interactions promotes tumorigenesis from human and mice glial cells

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Targeting of 5-aza-2'-deoxycytidine residues by chromatin-associated DNMT1 induces proteasomal degradation of the free enzyme

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MDC1: The art of keeping things in focus

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The DNA-damage response in human biology and disease

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Epigenetics in cancer

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Comparative analysis of different laser systems to study cellular responses to DNA damage in mammalian cells

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Essential function of Chk1 can be uncoupled from DNA damage checkpoint and replication control

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DNA methylation in development and human disease

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Double strand breaks can initiate gene silencing and SIRT1-dependent onset of DNA methylation in an exogenous promoter CpG island

1 reference

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ATR: an essential regulator of genome integrity

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A conserved proliferating cell nuclear antigen-interacting protein sequence in Chk1 is required for checkpoint function

1 reference

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Regulation of DNA double-strand break repair pathway choice

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RNF8 ubiquitylates histones at DNA double-strand breaks and promotes assembly of repair proteins

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The SRA protein Np95 mediates epigenetic inheritance by recruiting Dnmt1 to methylated DNA

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DNA methylation inhibitor 5-Aza-2'-deoxycytidine induces reversible genome-wide DNA damage that is distinctly influenced by DNA methyltransferases 1 and 3B.

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UHRF1 plays a role in maintaining DNA methylation in mammalian cells

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DNA damage, homology-directed repair, and DNA methylation

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Dynamics of Dnmt1 interaction with the replication machinery and its role in postreplicative maintenance of DNA methylation

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Complete inactivation of DNMT1 leads to mitotic catastrophe in human cancer cells

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27 September 2017

DNMT1 but not its interaction with the replication machinery is required for maintenance of DNA methylation in human cells

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Chromatin relaxation in response to DNA double-strand breaks is modulated by a novel ATM- and KAP-1 dependent pathway

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Spatial organization of the mammalian genome surveillance machinery in response to DNA strand breaks

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Rapid PIKK-dependent release of Chk1 from chromatin promotes the DNA-damage checkpoint response.

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ATM- and cell cycle-dependent regulation of ATR in response to DNA double-strand breaks

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Recruitment of DNA methyltransferase I to DNA repair sites

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EUKARYOTIC CYTOSINE METHYLTRANSFERASES

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Evidence that DNA damage detection machinery participates in DNA repair

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Identification and characterization of a novel and specific inhibitor of the ataxia-telangiectasia mutated kinase ATM

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Replication-independent chromatin loading of Dnmt1 during G2 and M phases

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Dial 9-1-1 for DNA damage: the Rad9-Hus1-Rad1 (9-1-1) clamp complex

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Human DNA methyltransferase 1 is required for maintenance of the histone H3 modification pattern

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Repeated phosphopeptide motifs in Claspin mediate the regulated binding of Chk1

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PCNA clamp facilitates action of DNA cytosine methyltransferase 1 on hemimethylated DNA

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DNMT1 knockout delivers a strong blow to genome stability and cell viability

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based on heuristic

inferred from PubMed ID database lookup

Human cancer cells require ATR for cell cycle progression following exposure to ionizing radiation

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12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Substrate specificity determinants of the checkpoint protein kinase Chk1

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12 December 2020

based on heuristic

inferred from PubMed ID database lookup

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10.1093/HMG/DDQ451

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Europe PubMed Central

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20940144%20AND%20SRC:MED&resulttype=core&format=json

15 February 2020

release_ydk6kmnforgbpcsazcyfx7b6qu

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24 November 2022

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15 February 2020

PubMed publication ID

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Europe PubMed Central

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15 February 2020

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