Construction by gene targeting in human cells of a "conditional' CDC2 mutant that rereplicates its DNA. (Q41125480)

27 September 2017

title

Construction by gene targeting in human cells of a "conditional' CDC2 mutant that rereplicates its DNA. (English)

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27 September 2017

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Itzhaki JE

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27 September 2017

Gilbert CS

series ordinal

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27 September 2017

Porter AC

series ordinal

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27 September 2017

language of work or name

English

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publication date

1 March 1997

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27 September 2017

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27 September 2017

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27 September 2017

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27 September 2017

page(s)

258-265

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Principles of CDK regulation

27 September 2017

cites work

1 reference

https://api.crossref.org/works/10.1038%2FNG0397-258

Universal control mechanism regulating onset of M-phase

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNG0397-258

Involvement of p34cdc2 in establishing the dependency of S phase on mitosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNG0397-258

Checkpoints in the cell cycle of fission yeast

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNG0397-258

Cyclin a is required for the onset of DNA replication in mammalian fibroblasts

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNG0397-258

Regulation of the cell cycle by the cdk2 protein kinase in cultured human fibroblasts

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNG0397-258

The FT210 cell line is a mouse G2 phase mutant with a temperature-sensitive CDC2 gene product

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNG0397-258

Requirement for p34cdc2 kinase is restricted to mitosis in the mammalian cdc2 mutant FT210

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNG0397-258

The inducible lac operator-repressor system is functional in mammalian cells.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNG0397-258

Testing an "in-out" targeting procedure for making subtle genomic modifications in mouse embryonic stem cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNG0397-258

Nuclear events of apoptosis in vitro in cell-free mitotic extracts: a model system for analysis of the active phase of apoptosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNG0397-258

Chromatin condensation during apoptosis is accompanied by degradation of lamin A+B, without enhanced activation of cdc2 kinase

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNG0397-258

Uncoupled cell cycle without mitosis induced by a protein kinase inhibitor, K-252a

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNG0397-258

The ts41 mutation in Chinese hamster cells leads to successive S phases in the absence of intervening G2, M, and G1

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNG0397-258

The cell cycle in polyploid megakaryocytes is associated with reduced activity of cyclin B1-dependent cdc2 kinase

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNG0397-258

Reversible tyrosine phosphorylation of cdc2: dephosphorylation accompanies activation during entry into mitosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNG0397-258

Lac repressor can regulate expression from a hybrid SV40 early promoter containing a lac operator in animal cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNG0397-258

Uncoupling of S phase and mitosis induced by anticancer agents in cells lacking p21

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNG0397-258

Altering the genome by homologous recombination

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNG0397-258

7 January 2021

Cell Cycle Regulation in the Yeasts Saccharomyces cerevisiae and Schizosaccharomyces pombe

1 reference

https://api.crossref.org/works/10.1038%2FNG0397-258

7 January 2021

Animal cell cycles and their control

1 reference

https://api.crossref.org/works/10.1038%2FNG0397-258

7 January 2021

Cyclin-dependent protein kinases: key regulators of the eukaryotic cell cycle

1 reference

https://api.crossref.org/works/10.1038%2FNG0397-258

7 January 2021

Temporal order of S phase and mitosis in fission yeast is determined by the state of the p34cdc2-mitotic B cyclin complex

1 reference

https://api.crossref.org/works/10.1038%2FNG0397-258

7 January 2021

p25rum1 orders S phase and mitosis by acting as an inhibitor of the p34cdc2 mitotic kinase

1 reference

https://api.crossref.org/works/10.1038%2FNG0397-258

7 January 2021

S-phase-promoting cyclin-dependent kinases prevent re-replication by inhibiting the transition of replication origins to a pre-replicative state

1 reference

https://api.crossref.org/works/10.1038%2FNG0397-258

7 January 2021

Cyclins and cancer. II: Cyclin D and CDK inhibitors come of age

1 reference

https://api.crossref.org/works/10.1038%2FNG0397-258

7 January 2021

The cdc2 kinase is a nuclear protein that is essential for mitosis in mammalian cells

1 reference

https://api.crossref.org/works/10.1038%2FNG0397-258

7 January 2021

cdc2 gene expression at the G1 to S transition in human T lymphocytes

1 reference

https://api.crossref.org/works/10.1038%2FNG0397-258

7 January 2021

Stringent regulation of stably integrated chloramphenicol acetyl transferase genes by E. coli lac repressor in monkey cells

1 reference

https://api.crossref.org/works/10.1038%2FNG0397-258

7 January 2021

Targeted disruption of a human interferon-inducible gene detected by secretion of human growth hormone

1 reference

https://api.crossref.org/works/10.1038%2FNG0397-258

7 January 2021

Targeted breakage of a human chromosome mediated by cloned human telomeric DNA

1 reference

https://api.crossref.org/works/10.1038%2FNG0397-258

7 January 2021

Gene targeting in human somatic cells. Complete inactivation of an interferon-inducible gene

1 reference

https://api.crossref.org/works/10.1038%2FNG0397-258

7 January 2021

Characterization of a newly derived human sarcoma cell line (HT-1080).

1 reference

https://api.crossref.org/works/10.1038%2FNG0397-258

7 January 2021

Simultaneous in situ detection of beta-interferon mRNA and DNA in the same cell

1 reference

https://api.crossref.org/works/10.1038%2FNG0397-258

7 January 2021

Features of apoptotic cells measured by flow cytometry

1 reference

https://api.crossref.org/works/10.1038%2FNG0397-258

7 January 2021

Premature p34cdc2 activation required for apoptosis.

1 reference

https://api.crossref.org/works/10.1038%2FNG0397-258

7 January 2021

Cdc2 activation is not required for thymocyte apoptosis

1 reference

https://api.crossref.org/works/10.1038%2FNG0397-258

7 January 2021

Analysis of inducers of the E.coli lac repressor system in mammalian cells and whole animals

1 reference

https://api.crossref.org/works/10.1038%2FNG0397-258

7 January 2021

Transcriptional activation by tetracyclines in mammalian cells

1 reference

https://api.crossref.org/works/10.1038%2FNG0397-258

7 January 2021

Coordinated synthesis and degradation of cdc2 in the mammalian cell cycle

1 reference

https://api.crossref.org/works/10.1038%2FNG0397-258

7 January 2021

Inducible gene targeting in mice

1 reference

https://api.crossref.org/works/10.1038%2FNG0397-258

7 January 2021

Study of the cell cycle-dependent assembly of the DNA pre-replication centres in Xenopus egg extracts.

1 reference

https://api.crossref.org/works/10.1038%2FNG0397-258

7 January 2021

Mammalian Cell Fusion : Studies on the Regulation of DNA Synthesis and Mitosis

1 reference

https://api.crossref.org/works/10.1038%2FNG0397-258

7 January 2021

Mitosis in transition

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https://api.crossref.org/works/10.1038%2FNG0397-258

7 January 2021

A p53-dependent mouse spindle checkpoint

1 reference

https://api.crossref.org/works/10.1038%2FNG0397-258

7 January 2021

Effect of staurosporine on MOLT-4 cell progression through G2 and on cytokinesis

1 reference

https://api.crossref.org/works/10.1038%2FNG0397-258

7 January 2021

Reversible arrest of proliferation of rat 3Y1 fibroblasts in both the G1 and G2 phases by trichostatin A

1 reference

https://api.crossref.org/works/10.1038%2FNG0397-258

7 January 2021

Effects of leptomycin B on the cell cycle of fibroblasts and fission yeast cells

1 reference

https://api.crossref.org/works/10.1038%2FNG0397-258

7 January 2021

A nonchromatographic assay for expression of the chloramphenicol acetyltransferase gene in eucaryotic cells

1 reference

https://api.crossref.org/works/10.1038%2FNG0397-258

7 January 2021

Selection for animal cells that express the Escherichia coli gene coding for xanthine-guanine phosphoribosyltransferase

1 reference

https://api.crossref.org/works/10.1038%2FNG0397-258

7 January 2021

A perfectly symmetric lac operator binds the lac repressor very tightly

1 reference

https://api.crossref.org/works/10.1038%2FNG0397-258

7 January 2021

Modifications of theE.coliLac repressor for expression in eukaryotic cells: effects of nuclear signal sequences on protein activity and nuclear accumulation

1 reference

https://api.crossref.org/works/10.1038%2FNG0397-258

7 January 2021

Flow cytometric analysis of G1- and G2/M-phase subpopulations in mammalian cell nuclei using side scatter and DNA content measurements

1 reference

https://api.crossref.org/works/10.1038%2FNG0397-258

7 January 2021

Activation of cdc2 protein kinase during mitosis in human cells: cell cycle-dependent phosphorylation and subunit rearrangement

1 reference

https://api.crossref.org/works/10.1038%2FNG0397-258

7 January 2021

Identifiers

DOI

10.1038/NG0397-258

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Dimensions Publication ID

27 September 2017

1038486934

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