Bruton's tyrosine kinase inhibitor BMS-986142 in experimental models of rheumatoid arthritis enhances efficacy of agents representing clinical standard-of-care. (Q41106264)

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scientific article published on 24 July 2017

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English	Bruton's tyrosine kinase inhibitor BMS-986142 in experimental models of rheumatoid arthritis enhances efficacy of agents representing clinical standard-of-care.	scientific article published on 24 July 2017

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26 March 2020

Bruton's tyrosine kinase inhibitor BMS-986142 in experimental models of rheumatoid arthritis enhances efficacy of agents representing clinical standard-of-care (English)

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26 March 2020

rheumatoid arthritis

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Scott H Watterson

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26 March 2020

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26 March 2020

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Kathleen M Gillooly

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26 March 2020

Claudine Pulicicchio

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26 March 2020

Mark A Pattoli

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26 March 2020

Lihong Cheng

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26 March 2020

Stacey Skala

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26 March 2020

Elizabeth M Heimrich

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26 March 2020

Kim W McIntyre

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26 March 2020

Tracy L Taylor

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26 March 2020

Daniel W Kukral

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26 March 2020

Shailesh Dudhgaonkar

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26 March 2020

Jignesh Nagar

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26 March 2020

Dana Banas

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26 March 2020

Joseph A Tino

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26 March 2020

Aberra Fura

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26 March 2020

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24 July 2017

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26 March 2020

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26 March 2020

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26 March 2020

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26 March 2020

e0181782

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26 March 2020

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24 July 2017

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Tofacitinib in Combination With Conventional Disease-Modifying Antirheumatic Drugs in Patients With Active Rheumatoid Arthritis: Patient-Reported Outcomes From a Phase III Randomized Controlled Trial

1 reference

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26 September 2017

Rheumatoid arthritis therapy reappraisal: strategies, opportunities and challenges

1 reference

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26 September 2017

B cells in rheumatoid arthritis: from pathogenic players to disease biomarkers.

1 reference

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26 September 2017

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1 reference

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26 September 2017

Novel small molecule therapeutics in rheumatoid arthritis

1 reference

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26 September 2017

Optimizing outcomes in rheumatoid arthritis patients with inadequate responses to disease-modifying anti-rheumatic drugs

1 reference

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26 September 2017

RN486, a selective Bruton's tyrosine kinase inhibitor, abrogates immune hypersensitivity responses and arthritis in rodents

1 reference

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26 September 2017

Comprehensive analysis of kinase inhibitor selectivity

1 reference

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26 September 2017

Positive regulators of osteoclastogenesis and bone resorption in rheumatoid arthritis

1 reference

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26 September 2017

The Bruton tyrosine kinase inhibitor PCI-32765 ameliorates autoimmune arthritis by inhibition of multiple effector cells

1 reference

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26 September 2017

Absence of Tec family kinases interleukin-2 inducible T cell kinase (Itk) and Bruton's tyrosine kinase (Btk) severely impairs Fc epsilonRI-dependent mast cell responses

1 reference

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26 September 2017

Btk regulates B cell receptor-mediated antigen processing and presentation by controlling actin cytoskeleton dynamics in B cells

1 reference

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26 September 2017

Dual functions of Bruton's tyrosine kinase and Tec kinase during Fcgamma receptor-induced signaling and phagocytosis.

1 reference

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26 September 2017

The tec family tyrosine kinase Btk Regulates RANKL-induced osteoclast maturation

1 reference

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26 September 2017

Adalimumab and methotrexate is more effective than adalimumab alone in patients with established rheumatoid arthritis: results from a 6-month longitudinal, observational, multicentre study

1 reference

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26 September 2017

Analysis of Fcgamma receptor haplotypes in rheumatoid arthritis: FCGR3A remains a major susceptibility gene at this locus, with an additional contribution from FCGR3B.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5524405

26 September 2017

Common mechanisms in immune-mediated inflammatory disease

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26 September 2017

Collagen type II (CII)-specific antibodies induce arthritis in the absence of T or B cells but the arthritis progression is enhanced by CII-reactive T cells

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26 September 2017

RANK-L and RANK: T cells, bone loss, and mammalian evolution

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26 September 2017

Infliximab (chimeric anti-tumour necrosis factor alpha monoclonal antibody) versus placebo in rheumatoid arthritis patients receiving concomitant methotrexate: a randomised phase III trial. ATTRACT Study Group

1 reference

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26 September 2017

Btk/Tec kinases regulate sustained increases in intracellular Ca2+ following B-cell receptor activation

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5524405

26 September 2017

Specific Btk inhibition suppresses B cell– and myeloid cell–mediated arthritis

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5524405

14 June 2018

A role for Bruton's tyrosine kinase in B cell antigen receptor-mediated activation of phospholipase C-gamma 2.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5524405

14 June 2018

The Bruton's tyrosine kinase gene is expressed throughout B cell differentiation, from early precursor B cell stages preceding immunoglobulin gene rearrangement up to mature B cell stages

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5524405

14 June 2018

Discovery of 6-Fluoro-5-(R)-(3-(S)-(8-fluoro-1-methyl-2,4-dioxo-1,2-dihydroquinazolin-3(4H)-yl)-2-methylphenyl)-2-(S)-(2-hydroxypropan-2-yl)-2,3,4,9-tetrahydro-1H-carbazole-8-carboxamide (BMS-986142): A Reversible Inhibitor of Bruton's Tyrosine Kina

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5524405

19 August 2018

Comparative efficacy and safety of tofacitinib, with or without methotrexate, in patients with active rheumatoid arthritis: a Bayesian network meta-analysis of randomized controlled trials

1 reference

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19 August 2018

The orally available Btk inhibitor ibrutinib (PCI-32765) protects against osteoclast-mediated bone loss.

1 reference

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19 August 2018

Rheumatoid arthritis. Triple therapy or etanercept after methotrexate failure in RA?

1 reference

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19 August 2018

Antiarthritis Effect of a Novel Bruton's Tyrosine Kinase (BTK) Inhibitor in Rat Collagen-Induced Arthritis and Mechanism-Based Pharmacokinetic/Pharmacodynamic Modeling: Relationships between Inhibition of BTK Phosphorylation and Efficacy

1 reference

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19 August 2018

Periodic, partial inhibition of IkappaB Kinase beta-mediated signaling yields therapeutic benefit in preclinical models of rheumatoid arthritis.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5524405

19 August 2018

Tyrosine kinases Btk and Tec regulate osteoclast differentiation by linking RANK and ITAM signals.

1 reference

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1 reference

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19 August 2018

Function of Bruton's tyrosine kinase during B cell development is partially independent of its catalytic activity.

1 reference

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1 reference

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1 reference

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19 August 2018

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1 reference

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Prevention and amelioration of collagen-induced arthritis by blockade of the CD28 co-stimulatory pathway: requirement for both B7-1 and B7-2

1 reference

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The PREMIER study: A multicenter, randomized, double-blind clinical trial of combination therapy with adalimumab plus methotrexate versus methotrexate alone or adalimumab alone in patients with early, aggressive rheumatoid arthritis who had not had

1 reference

https://pubmed.ncbi.nlm.nih.gov/28742141

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Essential role of T cell NF-kappa B activation in collagen-induced arthritis

1 reference

https://pubmed.ncbi.nlm.nih.gov/28742141

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Transphosphorylation of Bruton's tyrosine kinase on tyrosine 551 is critical for B cell antigen receptor function

1 reference

https://pubmed.ncbi.nlm.nih.gov/28742141

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Combined inhibition of tumor necrosis factor α and interleukin-17 as a therapeutic opportunity in rheumatoid arthritis: development and characterization of a novel bispecific antibody

1 reference

https://pubmed.ncbi.nlm.nih.gov/28742141

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Essential role of Fc gamma receptors in anti-type II collagen antibody-induced arthritis

1 reference

https://pubmed.ncbi.nlm.nih.gov/28742141

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Collagen-induced arthritis in mice

1 reference

https://pubmed.ncbi.nlm.nih.gov/28742141

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

B cell depletion delays collagen-induced arthritis in mice: arthritis induction requires synergy between humoral and cell-mediated immunity

1 reference

https://pubmed.ncbi.nlm.nih.gov/28742141

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

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10.1371/JOURNAL.PONE.0181782

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26 March 2020

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26 March 2020

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26 March 2020

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