Mechanisms underlying T-cell tolerance (Q41049046)

26 September 2017

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title

Mechanisms underlying T-cell tolerance (English)

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26 September 2017

Kruisbeek AM

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26 September 2017

Amsen D

series ordinal

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26 September 2017

publication date

1 April 1996

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Current Opinion in Immunology

26 September 2017

published in

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26 September 2017

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26 September 2017

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26 September 2017

page(s)

233-244

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Thymic selection: two pathways to life and two to death

26 September 2017

cites work

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7 January 2021

T cell receptor antagonists and partial agonists

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7 January 2021

Short-lived complexes between myelin basic protein peptides and IAk

1 reference

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7 January 2021

Low avidity recognition of self-antigen by T cells permits escape from central tolerance.

1 reference

https://api.crossref.org/works/10.1016%2FS0952-7915%2896%2980062-8

7 January 2021

Direct binding of autoimmune disease related T cell epitopes to purified Lewis rat MHC class II molecules

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7 January 2021

Immunological function of a defined T-cell population tolerized to low-affinity self antigens

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https://api.crossref.org/works/10.1016%2FS0952-7915%2896%2980062-8

7 January 2021

Thymocyte lineage commitment: is it instructed or stochastic?

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https://api.crossref.org/works/10.1016%2FS0952-7915%2896%2980062-8

7 January 2021

Molecular mechanisms underlying functional T-cell unresponsiveness.

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https://api.crossref.org/works/10.1016%2FS0952-7915%2896%2980062-8

7 January 2021

CTLA-4 can function as a negative regulator of T cell activation

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https://api.crossref.org/works/10.1016%2FS0952-7915%2896%2980062-8

7 January 2021

CD28 and CTLA-4 have opposing effects on the response of T cells to stimulation

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https://api.crossref.org/works/10.1016%2FS0952-7915%2896%2980062-8

7 January 2021

Distinct roles for CD28 and cytotoxic T lymphocyte-associated molecule-4 receptors during T cell activation?

1 reference

https://api.crossref.org/works/10.1016%2FS0952-7915%2896%2980062-8

7 January 2021

A negative regulatory function of B7 revealed in B7-1 transgenic mice

1 reference

https://api.crossref.org/works/10.1016%2FS0952-7915%2896%2980062-8

7 January 2021

Lymphoproliferative disorders with early lethality in mice deficient in Ctla-4

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7 January 2021

Loss of CTLA-4 leads to massive lymphoproliferation and fatal multiorgan tissue destruction, revealing a critical negative regulatory role of CTLA-4

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https://api.crossref.org/works/10.1016%2FS0952-7915%2896%2980062-8

7 January 2021

Negative selection of CD4+CD8+ thymocytes by T cell receptor-induced apoptosis requires a costimulatory signal that can be provided by CD28

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https://api.crossref.org/works/10.1016%2FS0952-7915%2896%2980062-8

7 January 2021

CD28-B7 interactions are not required for intrathymic clonal deletion

1 reference

https://api.crossref.org/works/10.1016%2FS0952-7915%2896%2980062-8

7 January 2021

Antigen/MHC-specific T cells are preferentially exported from the thymus in the presence of their MHC ligand.

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https://api.crossref.org/works/10.1016%2FS0952-7915%2896%2980062-8

7 January 2021

An essential role for gp39, the ligand for CD40, in thymic selection.

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https://api.crossref.org/works/10.1016%2FS0952-7915%2896%2980062-8

7 January 2021

The expansive role of CD40 and its ligand, gp39, in immunity

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https://api.crossref.org/works/10.1016%2FS0952-7915%2896%2980062-8

7 January 2021

Studies on the interdependence of gp39 and B7 expression and function during antigen-specific immune responses

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https://api.crossref.org/works/10.1016%2FS0952-7915%2896%2980062-8

7 January 2021

Induction of B cell costimulatory function by recombinant murine CD40 ligand

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https://api.crossref.org/works/10.1016%2FS0952-7915%2896%2980062-8

7 January 2021

Rapid induction of a novel costimulatory activity on B cells by CD40 ligand.

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https://api.crossref.org/works/10.1016%2FS0952-7915%2896%2980062-8

7 January 2021

CD40 ligand-transduced co-stimulation of T cells in the development of helper function

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https://api.crossref.org/works/10.1016%2FS0952-7915%2896%2980062-8

7 January 2021

Impairment of antigen-specific T-cell priming in mice lacking CD40 ligand

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https://api.crossref.org/works/10.1016%2FS0952-7915%2896%2980062-8

7 January 2021

Peripheral clonal elimination of functional T cells

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https://api.crossref.org/works/10.1016%2FS0952-7915%2896%2980062-8

7 January 2021

Extrathymic tolerance of mature T cells: clonal elimination as a consequence of immunity

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https://api.crossref.org/works/10.1016%2FS0952-7915%2896%2980062-8

7 January 2021

Programmed cell death and extrathymic reduction of Vβ8+CD4+ T cells in mice tolerant to Staphylococcus aureus enterotoxin B

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https://api.crossref.org/works/10.1016%2FS0952-7915%2896%2980062-8

7 January 2021

Peripheral selection of the T cell repertoire

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https://api.crossref.org/works/10.1016%2FS0952-7915%2896%2980062-8

7 January 2021

Virus persistence in acutely infected immunocompetent mice by exhaustion of antiviral cytotoxic effector T cells

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https://api.crossref.org/works/10.1016%2FS0952-7915%2896%2980062-8

7 January 2021

T cell immunity after a viral infection versus T cell tolerance induced by soluble viral peptides.

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https://api.crossref.org/works/10.1016%2FS0952-7915%2896%2980062-8

7 January 2021

Thymic and peripheral apoptosis of antigen-specific T cells might cooperate in establishing self tolerance.

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https://api.crossref.org/works/10.1016%2FS0952-7915%2896%2980062-8

7 January 2021

T cell deletion in high antigen dose therapy of autoimmune encephalomyelitis

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https://api.crossref.org/works/10.1016%2FS0952-7915%2896%2980062-8

7 January 2021

The liver eliminates T cells undergoing antigen-triggered apoptosis in vivo

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https://api.crossref.org/works/10.1016%2FS0952-7915%2896%2980062-8

7 January 2021

Visualization of peptide-specific T cell immunity and peripheral tolerance induction in vivo.

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https://api.crossref.org/works/10.1016%2FS0952-7915%2896%2980062-8

7 January 2021

Intrathymic and extrathymic clonal deletion of T cells

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https://api.crossref.org/works/10.1016%2FS0952-7915%2896%2980062-8

7 January 2021

Fate of H2-activated T lymphocytes in syngeneic hosts. I. Fate in lymphoid tissues and intestines traced with 3H-thymidine, 125I-deoxyuridine and 51chromium

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https://api.crossref.org/works/10.1016%2FS0952-7915%2896%2980062-8

7 January 2021

Clonal deletion as direct consequence of an in vivo T cell response to bacterial superantigen

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https://api.crossref.org/works/10.1016%2FS0952-7915%2896%2980062-8

7 January 2021

Exogenous superantigens acutely trigger distinct levels of peripheral T cell tolerance/immunosuppression: dose-response relationship.

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https://api.crossref.org/works/10.1016%2FS0952-7915%2896%2980062-8

7 January 2021

Proliferation is a prerequisite for bacterial superantigen-induced T cell apoptosis in vivo

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https://api.crossref.org/works/10.1016%2FS0952-7915%2896%2980062-8

7 January 2021

A functionally compromised intermediate in extrathymic CD8+ T cell deletion.

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https://api.crossref.org/works/10.1016%2FS0952-7915%2896%2980062-8

7 January 2021

Mechanisms of tolerance induction in major histocompatibility complex class II-restricted T cells specific for a blood-borne self-antigen.

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https://api.crossref.org/works/10.1016%2FS0952-7915%2896%2980062-8

7 January 2021

The progressive differentiation of primed T cells is associated with an increasing susceptibility to apoptosis.

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https://api.crossref.org/works/10.1016%2FS0952-7915%2896%2980062-8

7 January 2021

Limited capacity for tolerization of CD4+ T cells specific for a pancreatic beta cell neo-antigen.

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https://api.crossref.org/works/10.1016%2FS0952-7915%2896%2980062-8

7 January 2021

Anergy and exhaustion are independent mechanisms of peripheral T cell tolerance

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https://api.crossref.org/works/10.1016%2FS0952-7915%2896%2980062-8

7 January 2021

Fatal interactions: Fas-induced apoptosis of mature T cells

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https://api.crossref.org/works/10.1016%2FS0952-7915%2896%2980062-8

7 January 2021

Lymphoproliferation disorder in mice explained by defects in Fas antigen that mediates apoptosis

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https://api.crossref.org/works/10.1016%2FS0952-7915%2896%2980062-8

7 January 2021

Generalized lymphoproliferative disease in mice, caused by a point mutation in the Fas ligand

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https://api.crossref.org/works/10.1016%2FS0952-7915%2896%2980062-8

7 January 2021

Targeted mutation in the Fas gene causes hyperplasia in peripheral lymphoid organs and liver

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https://api.crossref.org/works/10.1016%2FS0952-7915%2896%2980062-8

7 January 2021

Dominant interfering Fas gene mutations impair apoptosis in a human autoimmune lymphoproliferative syndrome

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https://api.crossref.org/works/10.1016%2FS0952-7915%2896%2980062-8

7 January 2021

Mutations in Fas associated with human lymphoproliferative syndrome and autoimmunity

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https://api.crossref.org/works/10.1016%2FS0952-7915%2896%2980062-8

7 January 2021

Fas ligand mediates activation-induced cell death in human T lymphocytes

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https://api.crossref.org/works/10.1016%2FS0952-7915%2896%2980062-8

7 January 2021

The polypeptide encoded by the cDNA for human cell surface antigen Fas can mediate apoptosis

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https://api.crossref.org/works/10.1016%2FS0952-7915%2896%2980062-8

7 January 2021

Autocrine T-cell suicide mediated by APO-1/(Fas/CD95)

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https://api.crossref.org/works/10.1016%2FS0952-7915%2896%2980062-8

7 January 2021

Cell-autonomous Fas (CD95)/Fas-ligand interaction mediates activation-induced apoptosis in T-cell hybridomas.

1 reference

https://api.crossref.org/works/10.1016%2FS0952-7915%2896%2980062-8

7 January 2021

The fas antigen is involved in peripheral but not thymic deletion of T lymphocytes in T cell receptor transgenic mice

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https://api.crossref.org/works/10.1016%2FS0952-7915%2896%2980062-8

7 January 2021

Fas(CD95)/FasL interactions required for programmed cell death after T-cell activation.

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https://api.crossref.org/works/10.1016%2FS0952-7915%2896%2980062-8

7 January 2021

A role for CD95 ligand in preventing graft rejection

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https://api.crossref.org/works/10.1016%2FS0952-7915%2896%2980062-8

7 January 2021

Fas Ligand-Induced Apoptosis as a Mechanism of Immune Privilege

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https://api.crossref.org/works/10.1016%2FS0952-7915%2896%2980062-8

7 January 2021

Fas and Fas ligand: lpr and gld mutations

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https://api.crossref.org/works/10.1016%2FS0952-7915%2896%2980062-8

7 January 2021

Induction of apoptosis in mature T cells by tumour necrosis factor

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https://api.crossref.org/works/10.1016%2FS0952-7915%2896%2980062-8

7 January 2021

Mechanism of interleukin 12-mediated toxicities during experimental viral infections: role of tumor necrosis factor and glucocorticoids

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https://api.crossref.org/works/10.1016%2FS0952-7915%2896%2980062-8

7 January 2021

CTLA4 mediates antigen-specific apoptosis of human T cells

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https://api.crossref.org/works/10.1016%2FS0952-7915%2896%2980062-8

7 January 2021

Activation interferes with the APO-1 pathway in mature human T cells.

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https://api.crossref.org/works/10.1016%2FS0952-7915%2896%2980062-8

7 January 2021

CD28 costimulation can promote T cell survival by enhancing the expression of Bcl-XL.

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https://api.crossref.org/works/10.1016%2FS0952-7915%2896%2980062-8

7 January 2021

A naturally occurring soluble isoform of murine Fas generated by alternative splicing

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https://api.crossref.org/works/10.1016%2FS0952-7915%2896%2980062-8

7 January 2021

Self-ignorance in the peripheral T-cell pool

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https://api.crossref.org/works/10.1016%2FS0952-7915%2896%2980062-8

7 January 2021

Prevention of T cell anergy by signaling through the gamma c chain of the IL-2 receptor

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https://api.crossref.org/works/10.1016%2FS0952-7915%2896%2980062-8

7 January 2021

Multiple levels of peripheral tolerance

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https://api.crossref.org/works/10.1016%2FS0952-7915%2896%2980062-8

7 January 2021

Levels of peripheral T cell tolerance induced by different doses of tolerogen

1 reference

https://api.crossref.org/works/10.1016%2FS0952-7915%2896%2980062-8

7 January 2021

T cell awareness of paternal alloantigens during pregnancy

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https://api.crossref.org/works/10.1016%2FS0952-7915%2896%2980062-8

7 January 2021

The role of the T cell costimulator B7-1 in autoimmunity and the induction and maintenance of tolerance to peripheral antigen

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https://api.crossref.org/works/10.1016%2FS0952-7915%2896%2980062-8

7 January 2021

Ablation of "tolerance" and induction of diabetes by virus infection in viral antigen transgenic mice

1 reference

https://api.crossref.org/works/10.1016%2FS0952-7915%2896%2980062-8

7 January 2021

Virus infection triggers insulin-dependent diabetes mellitus in a transgenic model: role of anti-self (virus) immune response

1 reference

https://api.crossref.org/works/10.1016%2FS0952-7915%2896%2980062-8

7 January 2021

Mice expressing both B7-1 and viral glycoprotein on pancreatic beta cells along with glycoprotein-specific transgenic T cells develop diabetes due to a breakdown of T-lymphocyte unresponsiveness

1 reference

https://api.crossref.org/works/10.1016%2FS0952-7915%2896%2980062-8

7 January 2021

T-cell responsiveness to an oncogenic peripheral protein and spontaneous autoimmunity in transgenic mice

1 reference

https://api.crossref.org/works/10.1016%2FS0952-7915%2896%2980062-8

7 January 2021

A Theory of Self-Nonself Discrimination: Paralysis and induction involve the recognition of one and two determinants on an antigen, respectively

1 reference

https://api.crossref.org/works/10.1016%2FS0952-7915%2896%2980062-8

7 January 2021

Fibroblasts as efficient antigen-presenting cells in lymphoid organs

1 reference

https://api.crossref.org/works/10.1016%2FS0952-7915%2896%2980062-8

7 January 2021

T helper cell subsets in insulin-dependent diabetes

1 reference

https://api.crossref.org/works/10.1016%2FS0952-7915%2896%2980062-8

7 January 2021

A role for non-MHC genetic polymorphism in susceptibility to spontaneous autoimmunity

1 reference

https://api.crossref.org/works/10.1016%2FS0952-7915%2896%2980062-8

7 January 2021

An altered peptide ligand mediates immune deviation and prevents autoimmune encephalomyelitis

1 reference

https://api.crossref.org/works/10.1016%2FS0952-7915%2896%2980062-8

7 January 2021

Th1 and Th2 CD4+ T cells in the pathogenesis of organ-specific autoimmune diseases.

1 reference

https://api.crossref.org/works/10.1016%2FS0952-7915%2896%2980062-8

7 January 2021

Relationships among antigen presentation, cytokines, immune deviation, and autoimmune disease

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https://api.crossref.org/works/10.1016%2FS0952-7915%2896%2980062-8

7 January 2021

Lymphocyte responses and cytokines

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https://api.crossref.org/works/10.1016%2FS0952-7915%2896%2980062-8

7 January 2021

Production of interleukin 10 by islet cells accelerates immune-mediated destruction of beta cells in nonobese diabetic mice

1 reference

https://api.crossref.org/works/10.1016%2FS0952-7915%2896%2980062-8

7 January 2021

Regulatory T cell clones induced by oral tolerance: suppression of autoimmune encephalomyelitis

1 reference

https://api.crossref.org/works/10.1016%2FS0952-7915%2896%2980062-8

7 January 2021

Peripheral deletion of antigen-reactive T cells in oral tolerance.

1 reference

https://api.crossref.org/works/10.1016%2FS0952-7915%2896%2980062-8

7 January 2021

B7-1 and B7-2 costimulatory molecules activate differentially the Th1/Th2 developmental pathways: application to autoimmune disease therapy

1 reference

https://api.crossref.org/works/10.1016%2FS0952-7915%2896%2980062-8

7 January 2021

Differential effects of anti-B7-1 and anti-B7-2 monoclonal antibody treatment on the development of diabetes in the nonobese diabetic mouse

1 reference

https://api.crossref.org/works/10.1016%2FS0952-7915%2896%2980062-8

7 January 2021

Modulation of cytokine patterns of human autoreactive T cell clones by a single amino acid substitution of their peptide ligand

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https://api.crossref.org/works/10.1016%2FS0952-7915%2896%2980062-8

7 January 2021

Selective apoptosis of CD4+CD8+ thymocytes by the anti-Fas antibody

1 reference

https://api.crossref.org/works/10.1016%2FS0952-7915%2896%2980062-8

7 January 2021

10.1016/S0952-7915(96)80062-8

Identifiers

DOI

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26 September 2017

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