Gain-of-function mutant p53 promotes cell growth and cancer cell metabolism via inhibition of AMPK activation. (Q41046980)

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19 March 2020

title

Gain-of-function mutant p53 promotes cell growth and cancer cell metabolism via inhibition of AMPK activation (English)

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19 March 2020

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Gordon B Mills

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Mien-Chie Hung

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Yongkun Wei

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Ge Zhou

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Jiping Wang

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Mei Zhao

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Tong-Xin Xie

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Noriaki Tanaka

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Ameeta A Patel

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Alexandra M Ward

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Samar A Jasser

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Heath D Skinner

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Alison Lea Fitzgerald

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Abdullah A Osman

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Xuefeng Xia

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Zhou Songyang

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Carlos Caulin

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Jiyong Liang

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19 March 2020

Jeffrey N Myers

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publication date

22 May 2014

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19 March 2020

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volume

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issue

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page(s)

960-974

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AMP-activated protein kinase induces p53 by phosphorylating MDMX and inhibiting its activity

19 March 2020

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Various p53 mutant proteins differently regulate the Ras circuit to induce a cancer-related gene signature

26 September 2017

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Mutant p53 disrupts mammary tissue architecture via the mevalonate pathway

26 September 2017

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Gain-of-function mutant p53 but not p53 deletion promotes head and neck cancer progression in response to oncogenic K-ras.

26 September 2017

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AMP-activated protein kinase: an energy sensor that regulates all aspects of cell function

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Disruptive TP53 mutation is associated with aggressive disease characteristics in an orthotopic murine model of oral tongue cancer

26 September 2017

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The AMPK signalling pathway coordinates cell growth, autophagy and metabolism

26 September 2017

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Exome sequencing of head and neck squamous cell carcinoma reveals inactivating mutations in NOTCH1

26 September 2017

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26 September 2017

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A fluorescent reporter of AMPK activity and cellular energy stress

26 September 2017

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AMPK phosphorylates and inhibits SREBP activity to attenuate hepatic steatosis and atherosclerosis in diet-induced insulin-resistant mice

26 September 2017

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26 September 2017

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The regulation of energy metabolism and the IGF-1/mTOR pathways by the p53 protein

26 September 2017

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26 September 2017

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Mutant p53 gain-of-function in cancer

26 September 2017

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Development of protein kinase activators: AMPK as a target in metabolic disorders and cancer.

26 September 2017

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26 September 2017

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Heterozygosity for hypoxia inducible factor 1alpha decreases the incidence of thymic lymphomas in a p53 mutant mouse model

26 September 2017

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26 September 2017

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26 September 2017

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26 September 2017

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Mutant p53 facilitates pro-angiogenic, hyperproliferative phenotype in response to chronic relative hypoxia

26 September 2017

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AMP-activated protein kinase induces a p53-dependent metabolic checkpoint

26 September 2017

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Regulation of fatty acid synthesis and oxidation by the AMP-activated protein kinase

26 September 2017

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A leucine-rich nuclear export signal in the p53 tetramerization domain: regulation of subcellular localization and p53 activity by NES masking

26 September 2017

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Characterization of the AMP-activated protein kinase kinase from rat liver and identification of threonine 172 as the major site at which it phosphorylates AMP-activated protein kinase

26 September 2017

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Mutant p53 protein localized in the cytoplasm inhibits autophagy

26 September 2017

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Activation of AMP-activated protein kinase induces p53-dependent apoptotic cell death in response to energetic stress

19 August 2018

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S-adenosylmethionine attenuates hepatic lipid synthesis in micropigs fed ethanol with a folate-deficient diet

19 August 2018

1 reference

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Gain of function of a p53 hot spot mutation in a mouse model of Li-Fraumeni syndrome.

19 August 2018

1 reference

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Gain of function of mutant p53 by coaggregation with multiple tumor suppressors

19 August 2018

1 reference

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Phosphorylation of rat muscle acetyl-CoA carboxylase by AMP-activated protein kinase and protein kinase A

2 December 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/24857548

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Mutant p53 gain of function in two mouse models of Li-Fraumeni syndrome

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/24857548

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Localization of AMP kinase is regulated by stress, cell density, and signaling through the MEK-->ERK1/2 pathway

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/24857548

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1016/J.MOLCEL.2014.04.024

1 reference

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19 March 2020

1 reference

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19 March 2020

PubMed publication ID

24857548

1 reference

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