ALS Mutations Disrupt Phase Separation Mediated by α-Helical Structure in the TDP-43 Low-Complexity C-Terminal Domain. (Q41036092)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27545621%20AND%20SRC:MED&resulttype=core&format=json

21 March 2020

title

ALS Mutations Disrupt Phase Separation Mediated by α-Helical Structure in the TDP-43 Low-Complexity C-Terminal Domain (English)

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27545621%20AND%20SRC:MED&resulttype=core&format=json

amyotrophic lateral sclerosis

21 March 2020

main subject

1 reference

1 reference

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21 March 2020

author name string

Alexander E Conicella

series ordinal

1 reference

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21 March 2020

Gül H Zerze

series ordinal

1 reference

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21 March 2020

Jeetain Mittal

series ordinal

1 reference

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21 March 2020

publication date

18 August 2016

1 reference

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21 March 2020

1 reference

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21 March 2020

volume

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21 March 2020

issue

1 reference

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21 March 2020

page(s)

1537-1549

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27545621%20AND%20SRC:MED&resulttype=core&format=json

Two mutations G335D and Q343R within the amyloidogenic core region of TDP-43 influence its aggregation and inclusion formation

21 March 2020

cites work

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5014597

ATPase-Modulated Stress Granules Contain a Diverse Proteome and Substructure.

26 September 2017

1 reference

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Phosphorylation of TAR DNA-binding Protein of 43 kDa (TDP-43) by Truncated Casein Kinase 1δ Triggers Mislocalization and Accumulation of TDP-43.

26 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5014597

The TDP-43 N-terminal domain structure at high resolution

26 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5014597

ALS-Causing Mutations Significantly Perturb the Self-Assembly and Interaction with Nucleic Acid of the Intrinsically Disordered Prion-Like Domain of TDP-43.

26 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5014597

Phase separation in biology; functional organization of a higher order

26 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5014597

The LC Domain of hnRNPA2 Adopts Similar Conformations in Hydrogel Polymers, Liquid-like Droplets, and Nuclei

26 September 2017

1 reference

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Residue-by-Residue View of In Vitro FUS Granules that Bind the C-Terminal Domain of RNA Polymerase II

26 September 2017

1 reference

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Formation and Maturation of Phase-Separated Liquid Droplets by RNA-Binding Proteins

26 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5014597

Functional Significance of TDP-43 Mutations in Disease

26 September 2017

1 reference

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Phase separation by low complexity domains promotes stress granule assembly and drives pathological fibrillization

26 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5014597

The s2D method: simultaneous sequence-based prediction of the statistical populations of ordered and disordered regions in proteins

26 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5014597

Balanced Protein-Water Interactions Improve Properties of Disordered Proteins and Non-Specific Protein Association

26 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5014597

Axonal transport of TDP-43 mRNA granules is impaired by ALS-causing mutations

26 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5014597

Divergent phenotypes in mutant TDP-43 transgenic mice highlight potential confounds in TDP-43 transgenic modeling

26 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5014597

"Structural characterization of the minimal segment of TDP-43 competent for aggregation".

26 September 2017

1 reference

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RNA seeds higher-order assembly of FUS protein

26 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5014597

Molecular basis of UG-rich RNA recognition by the human splicing factor TDP-43

26 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5014597

Converging mechanisms in ALS and FTD: disrupted RNA and protein homeostasis

26 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5014597

The RNA-binding protein repertoire of embryonic stem cells.

26 September 2017

1 reference

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Probing the transient dark state of substrate binding to GroEL by relaxation-based solution NMR

26 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5014597

Structural transformation of the amyloidogenic core region of TDP-43 protein initiates its aggregation and cytoplasmic inclusion

26 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5014597

ALS-linked TDP-43 mutations produce aberrant RNA splicing and adult-onset motor neuron disease without aggregation or loss of nuclear TDP-43.

26 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5014597

The truncated C-terminal RNA recognition motif of TDP-43 protein plays a key role in forming proteinaceous aggregates

26 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5014597

Structural Ensemble of an Intrinsically Disordered Polypeptide

26 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5014597

Coaggregation of RNA-binding proteins in a model of TDP-43 proteinopathy with selective RGG motif methylation and a role for RRM1 ubiquitination

26 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5014597

Cell-free formation of RNA granules: low complexity sequence domains form dynamic fibers within hydrogels

26 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5014597

The tip of the iceberg: RNA-binding proteins with prion-like domains in neurodegenerative disease.

26 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5014597

The quantitative proteome of a human cell line.

26 September 2017

1 reference

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Structure-function studies of FMRP RGG peptide recognition of an RNA duplex-quadruplex junction

26 September 2017

1 reference

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SPARTA+: a modest improvement in empirical NMR chemical shift prediction by means of an artificial neural network

26 September 2017

1 reference

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Neurotoxic effects of TDP-43 overexpression in C. elegans

26 September 2017

1 reference

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Global analysis of TDP-43 interacting proteins reveals strong association with RNA splicing and translation machinery.

26 September 2017

1 reference

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TDP-43 mutant transgenic mice develop features of ALS and frontotemporal lobar degeneration

26 September 2017

1 reference

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TDP-43 is recruited to stress granules in conditions of oxidative insult.

26 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5014597

TDP-43 is intrinsically aggregation-prone, and amyotrophic lateral sclerosis-linked mutations accelerate aggregation and increase toxicity

26 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5014597

Functional mapping of the interaction between TDP-43 and hnRNP A2 in vivo

26 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5014597

TDP-43 immunoreactivity in hippocampal sclerosis and Alzheimer's disease

26 September 2017

1 reference

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Sensitivity of secondary structure propensities to sequence differences between alpha- and gamma-synuclein: implications for fibrillation

26 September 2017

1 reference

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Visualization of transient encounter complexes in protein-protein association.

26 September 2017

1 reference

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Ubiquitinated TDP-43 in frontotemporal lobar degeneration and amyotrophic lateral sclerosis

26 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5014597

Strategies to maximize heterologous protein expression in Escherichia coli with minimal cost

26 September 2017

1 reference

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TDP-43 binds heterogeneous nuclear ribonucleoprotein A/B through its C-terminal tail: an important region for the inhibition of cystic fibrosis transmembrane conductance regulator exon 9 splicing

26 September 2017

1 reference

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RefDB: a database of uniformly referenced protein chemical shifts

26 September 2017

1 reference

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Probability-based protein secondary structure identification using combined NMR chemical-shift data

26 September 2017

1 reference

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Nuclear factor TDP-43 and SR proteins promote in vitro and in vivo CFTR exon 9 skipping

26 September 2017

1 reference

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Dictionary of protein secondary structure: pattern recognition of hydrogen-bonded and geometrical features

26 September 2017

1 reference

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The chemical shift index: a fast and simple method for the assignment of protein secondary structure through NMR spectroscopy

26 September 2017

1 reference

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Phase transition of a disordered nuage protein generates environmentally responsive membraneless organelles

26 September 2017

1 reference

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TDP-43 loss of cellular function through aggregation requires additional structural determinants beyond its C-terminal Q/N prion-like domain

26 September 2017

1 reference

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Requirements for stress granule recruitment of fused in sarcoma (FUS) and TAR DNA-binding protein of 43 kDa (TDP-43)

14 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5014597

Wild-type and A315T mutant TDP-43 exert differential neurotoxicity in a Drosophila model of ALS.

14 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5014597

Efficient Simulation of Explicitly Solvated Proteins in the Well-Tempered Ensemble

14 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5014597

Sequence- and Temperature-Dependent Properties of Unfolded and Disordered Proteins from Atomistic Simulations

19 August 2018

1 reference

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A Liquid-to-Solid Phase Transition of the ALS Protein FUS Accelerated by Disease Mutation.

19 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5014597

Role of selected mutations in the Q/N rich region of TDP-43 in EGFP-12xQ/N-induced aggregate formation.

19 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5014597

Screening of the SOD1, FUS, TARDBP, ANG, and OPTN mutations in Korean patients with familial and sporadic ALS

19 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5014597

Germline P granules are liquid droplets that localize by controlled dissolution/condensation

19 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5014597

Identification of casein kinase-1 phosphorylation sites on TDP-43.

19 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5014597

Limits on variations in protein backbone dynamics from precise measurements of scalar couplings.

19 August 2018

1 reference

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Human, Drosophila, and C.elegans TDP43: nucleic acid binding properties and splicing regulatory function

19 August 2018

1 reference

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CPMG sequences with enhanced sensitivity to chemical exchange

19 August 2018

1 reference

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Analysis of main chain torsion angles in proteins: prediction of NMR coupling constants for native and random coil conformations

19 August 2018

1 reference

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The N-terminus of TDP-43 promotes its oligomerization and enhances DNA binding affinity

19 August 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/27545621

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

SS-map: Visualizing cooperative secondary structure elements in protein ensembles

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/27545621

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1016/J.STR.2016.07.007

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27545621%20AND%20SRC:MED&resulttype=core&format=json

21 March 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27545621%20AND%20SRC:MED&resulttype=core&format=json

21 March 2020

PubMed publication ID

27545621

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27545621%20AND%20SRC:MED&resulttype=core&format=json