Epithelial-derived IL-33 promotes intestinal tumorigenesis in Apc Min/+ mice (Q41019883)

25 September 2017

Epithelial-derived IL-33 promotes intestinal tumorigenesis in Apc Min/+ mice (English)

1 reference

25 September 2017

Lili Chen

0 references

Gerold Bongers

0 references

Zhengxiang He

0 references

Noam Harpaz

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Glaucia C Furtado

1 reference

25 September 2017

Fabricio O Souto

1 reference

25 September 2017

Claudia Canasto-Chibuque

1 reference

25 September 2017

Madhura Deshpande

1 reference

25 September 2017

Huaibin M Ko

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25 September 2017

Kevin Kelley

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25 September 2017

Sergio A Lira

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25 September 2017

language of work or name

English

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publication date

14 July 2017

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25 September 2017

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25 September 2017

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25 September 2017

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25 September 2017

5520

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Creative Commons Attribution 4.0 International

25 September 2017

start time

14 July 2017

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April 2022 Public Data File from Crossref

copyrighted

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describes a project that uses

ImageJ

1 reference

11 June 2022

https://www.ebi.ac.uk/europepmc/webservices/rest/PMC5511216/fullTextXML

inferred from PubMed Central ID database lookup

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IL33 Promotes Colon Cancer Cell Stemness via JNK Activation and Macrophage Recruitment

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IL-33 regulates the IgA-microbiota axis to restrain IL-1α-dependent colitis and tumorigenesis

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IL-33 Receptor-Expressing Regulatory T Cells Are Highly Activated, Th2 Biased and Suppress CD4 T Cell Proliferation through IL-10 and TGFβ Release

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The IL-33/ST2 pathway contributes to intestinal tumorigenesis in humans and mice

26 September 2017

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IL-33 Signaling Protects from Murine Oxazolone Colitis by Supporting Intestinal Epithelial Function

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IL-33 promotes an innate immune pathway of intestinal tissue protection dependent on amphiregulin-EGFR interactions

26 September 2017

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IL-33 activates tumor stroma to promote intestinal polyposis.

26 September 2017

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26 September 2017

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Tumoral expression of IL-33 inhibits tumor growth and modifies the tumor microenvironment through CD8+ T and NK cells

26 September 2017

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Interleukin-33 and inflammatory bowel diseases: lessons from human studies

26 September 2017

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Interplay of host microbiota, genetic perturbations, and inflammation promotes local development of intestinal neoplasms in mice

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Interleukin-33/ST2 axis promotes breast cancer growth and metastases by facilitating intratumoral accumulation of immunosuppressive and innate lymphoid cells

26 September 2017

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Adenomatous polyps are driven by microbe-instigated focal inflammation and are controlled by IL-10-producing T cells

26 September 2017

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Opposing Functions of Classic and Novel IL-1 Family Members in Gut Health and Disease

26 September 2017

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The role of IL-33 in gut mucosal inflammation.

26 September 2017

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Associations between genetic polymorphisms in IL-33, IL1R1 and risk for inflammatory bowel disease

26 September 2017

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Transgenic expression of IL-33 activates CD8(+) T cells and NK cells and inhibits tumor growth and metastasis in mice

26 September 2017

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IL-33-induced alterations in murine intestinal function and cytokine responses are MyD88, STAT6, and IL-13 dependent

26 September 2017

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IL-33 drives biphasic IL-13 production for noncanonical Type 2 immunity against hookworms

26 September 2017

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Neutralisation of the interleukin-33/ST2 pathway ameliorates experimental colitis through enhancement of mucosal healing in mice

26 September 2017

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The goblet cell is the cellular source of the anti-microbial angiogenin 4 in the large intestine post Trichuris muris infection

26 September 2017

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26 September 2017

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Intestinal inflammation targets cancer-inducing activity of the microbiota.

26 September 2017

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Mucin Muc2 deficiency and weaning influences the expression of the innate defense genes Reg3β, Reg3γ and angiogenin-4.

26 September 2017

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Presensitizing with a Toll-like receptor 3 ligand impairs CD8 T-cell effector differentiation and IL-33 responsiveness

26 September 2017

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Interleukin-33 and the function of innate lymphoid cells

26 September 2017

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Interleukin-33 ameliorates experimental colitis through promoting Th2/Foxp3⁺ regulatory T-cell responses in mice

26 September 2017

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Novel cytokine signaling pathways in inflammatory bowel disease: insight into the dichotomous functions of IL-33 during chronic intestinal inflammation

26 September 2017

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Tumor-associated Macrophages (TAM) and Inflammation in Colorectal Cancer

26 September 2017

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Inflammatory bowel disease-associated interleukin-33 is preferentially expressed in ulceration-associated myofibroblasts.

26 September 2017

1 reference

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Interleukin-33 contributes to both M1 and M2 chemokine marker expression in human macrophages

26 September 2017

1 reference

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IL-33 is a crucial amplifier of innate rather than acquired immunity

26 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5511216

Epithelial-derived IL-33 and its receptor ST2 are dysregulated in ulcerative colitis and in experimental Th1/Th2 driven enteritis

26 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5511216

Disease-associated functions of IL-33: the new kid in the IL-1 family

26 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5511216

IL-33 is upregulated in colonocytes of ulcerative colitis.

26 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5511216

IL-33 amplifies the polarization of alternatively activated macrophages that contribute to airway inflammation

26 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5511216

Immune responses to the microbiota at the intestinal mucosal surface

26 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5511216

T-regulatory cells shift from a protective anti-inflammatory to a cancer-promoting proinflammatory phenotype in polyposis

26 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5511216

IL-33 enhances lipopolysaccharide-induced inflammatory cytokine production from mouse macrophages by regulating lipopolysaccharide receptor complex

26 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5511216

IL-1 receptor accessory protein and ST2 comprise the IL-33 receptor complex

26 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5511216

IL-33, an interleukin-1-like cytokine that signals via the IL-1 receptor-related protein ST2 and induces T helper type 2-associated cytokines

26 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5511216

RELMbeta/FIZZ2 is a goblet cell-specific immune-effector molecule in the gastrointestinal tract

26 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5511216

Loss of Apc in vivo immediately perturbs Wnt signaling, differentiation, and migration

26 September 2017

1 reference

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Molecular characterization of NF-HEV, a nuclear factor preferentially expressed in human high endothelial venules

26 September 2017

1 reference

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Angiogenins: a new class of microbicidal proteins involved in innate immunity

26 September 2017

1 reference

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A family of tissue-specific resistin-like molecules

26 September 2017

1 reference

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Tissue microarrays for high-throughput molecular profiling of tumor specimens

26 September 2017

1 reference

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Molecular cloning and characterization of a second subunit of the interleukin 1 receptor complex

26 September 2017

1 reference

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Loss of Apc heterozygosity and abnormal tissue building in nascent intestinal polyps in mice carrying a truncated Apc gene

26 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5511216

A dominant mutation that predisposes to multiple intestinal neoplasia in the mouse

26 September 2017

1 reference

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Loss of interleukin 33 expression in colonic crypts - a potential marker for disease remission in ulcerative colitis

26 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5511216

IL-23 activates innate lymphoid cells to promote neonatal intestinal pathology.

14 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5511216

IL-33 synergizes with TCR and IL-12 signaling to promote the effector function of CD8+ T cells

14 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5511216

In Vivo Expansion of Activated Foxp3+ Regulatory T Cells and Establishment of a Type 2 Immune Response upon IL-33 Treatment Protect against Experimental Arthritis.

14 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5511216

IL-33/ST2 pathway contributes to metastasis of human colorectal cancer.

19 August 2018

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5511216

IL-33 promotes GATA-3 polarization of gut-derived T cells in experimental and ulcerative colitis.

19 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5511216

Interleukin-33 exacerbates acute colitis via interleukin-4 in mice

19 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5511216

Interleukin-33 expression is specifically enhanced in inflamed mucosa of ulcerative colitis.

19 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5511216

Suppression of interleukin-33 bioactivity through proteolysis by apoptotic caspases.

19 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5511216

T1/ST2-deficient mice demonstrate the importance of T1/ST2 in developing primary T helper cell type 2 responses

19 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5511216

IL-33 attenuates development and perpetuation of chronic intestinal inflammation

19 August 2018

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12 December 2020

Interleukin-33 suppresses Notch ligand expression and prevents goblet cell depletion in dextran sulfate sodium-induced colitis

1 reference

12 December 2020

Regulatory sequences of the mouse villin gene that efficiently drive transgenic expression in immature and differentiated epithelial cells of small and large intestines

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12 December 2020

Characterization of the novel ST2/IL-33 system in patients with inflammatory bowel disease

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12 December 2020

10.1038/S41598-017-05716-Z

Identifiers

DOI

1 reference

25 September 2017

1 reference

25 September 2017

PubMed publication ID

28710436

1 reference