NMDA antagonists: antiepileptic-neuroprotective drugs with diversified neuropharmacological profiles (Q41007572)

25 September 2017

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title

NMDA antagonists: antiepileptic-neuroprotective drugs with diversified neuropharmacological profiles (English)

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25 September 2017

S Sagratella

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25 September 2017

publication date

1 July 1995

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25 September 2017

published in

Pharmacological Research

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25 September 2017

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25 September 2017

issue

1-2

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25 September 2017

page(s)

1-13

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The dissociative anaesthetics, ketamine and phencyclidine, selectively reduce excitation of central mammalian neurones by N-methyl-aspartate

25 September 2017

cites work

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7 January 2021

Comparison of sigma- and kappa-opiate receptor ligands as excitatory amino acid antagonists

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7 January 2021

Excitatory Amino Acid Transmitters

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7 January 2021

Effects of excitatory amino acids and their antagonists on membrane and action potentials of cat caudate neurones

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7 January 2021

Possible therapeutic applications of antagonists of excitatory amino acid neurotransmitters

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7 January 2021

Magnesium gates glutamate-activated channels in mouse central neurones

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7 January 2021

Differential effects of dextrorphan and levorphanol on the excitation of rat spinal neurons by amino acids.

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7 January 2021

[3H]MK-801 labels a site on the N-methyl-D-aspartate receptor channel complex in rat brain membranes

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7 January 2021

Glycine potentiates the NMDA response in cultured mouse brain neurons

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7 January 2021

Zinc selectively blocks the action of N-methyl-D-aspartate on cortical neurons

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7 January 2021

Cooperative modulation of [3H]MK-801 binding to the N-methyl-D-aspartate receptor-ion channel complex by L-glutamate, glycine, and polyamines

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7 January 2021

Magnesium ions block an N-methyl-D-aspartate receptor-mediated component of synaptic transmission in rat hippocampus

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7 January 2021

Magnesium-free medium activates seizure-like events in the rat hippocampal slice

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7 January 2021

Effects of ketamine and (+)cyclazocine on 4-aminopyridine and "magnesium free" epileptogenic activity in hippocampal slices of rats

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7 January 2021

Inhibitory influence of excitatory amino acid antagonists on penicillin-induced epileptiform bursting in rat hippocampal slices.

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7 January 2021

N-methylaspartate receptors mediate epileptiform activity evoked in some, but not all, conditions in rat neocortical slices

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7 January 2021

The NMDA receptor antagonist 2-amino-5-phosphonovalerate blocks stimulus train-induced epileptogenesis but not epileptiform bursting in the rat hippocampal slice

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7 January 2021

NMDA antagonists differentiate epileptogenesis from seizure expression in an in vitro model

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7 January 2021

Potassium-dependent prolonged field bursts in the dentate gyrus: effects of extracellular calcium and amino acid receptor antagonists

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7 January 2021

Transition from normal to epileptiform activity in kindled rat hippocampal slices

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7 January 2021

Anticonvulsant action of excitatory amino acid antagonists

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7 January 2021

Effects of excitatory amino-acid antagonists on the anticonvulsant action of phenobarbital or diphenylhydanton in mice

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7 January 2021

Protection against chemically induced seizures by 2-amino-7-phosphonoheptanoic acid

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7 January 2021

Effect of glutamate receptor antagonists on N-methyl-D-aspartate- and (S)-α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid-induced convulsant effects in mice and rats

1 reference

https://api.crossref.org/works/10.1016%2FS1043-6618%2895%2980002-6

7 January 2021

Anticonvulsant effects of phencyclidine-like drugs: relation to N-methyl-D-aspartic acid antagonism

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https://api.crossref.org/works/10.1016%2FS1043-6618%2895%2980002-6

7 January 2021

MK-801 sensitizes rats to pilocarpine induced limbic seizures and status epilepticus.

1 reference

https://api.crossref.org/works/10.1016%2FS1043-6618%2895%2980002-6

7 January 2021

Potentiation of kainic acid epileptogenicity and sparing from neuronal damage by an NMDA receptor antagonist

1 reference

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7 January 2021

Antiepileptic action of excitatory amino acid antagonists in the photosensitive baboon, papio papio

1 reference

https://api.crossref.org/works/10.1016%2FS1043-6618%2895%2980002-6

7 January 2021

Ketamine: convulsant or anti-convulsant?

1 reference

https://api.crossref.org/works/10.1016%2FS1043-6618%2895%2980002-6

7 January 2021

Phencyclidine-like effect of cyclazocine on pentylentetrazol-induced seizures in laboratory animals

1 reference

https://api.crossref.org/works/10.1016%2FS1043-6618%2895%2980002-6

7 January 2021

Thalamic NMDA receptors in the gamma-hydroxybutyrate model of absence seizures: a cerebral microinjection study in rats

1 reference

https://api.crossref.org/works/10.1016%2FS1043-6618%2895%2980002-6

7 January 2021

Effects of ketamine on EEG activity in cats and monkeys

1 reference

https://api.crossref.org/works/10.1016%2FS1043-6618%2895%2980002-6

7 January 2021

An investigation on the mechanism of anticonvulsant action of ketamine and phencyclidine on convulsions due to cortical application of penicillin in rabbits.

1 reference

https://api.crossref.org/works/10.1016%2FS1043-6618%2895%2980002-6

7 January 2021

Inhibitory influence of morphinans on ictal and interictal EEG changes induced by cortical application of penicillin in rabbits: a comparative study with NMDA antagonists and pentobarbitone

1 reference

https://api.crossref.org/works/10.1016%2FS1043-6618%2895%2980002-6

7 January 2021

Non-NMDA glutamate receptors are involved in the maintenance of status epilepticus

1 reference

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7 January 2021

Ketamine-induced changes in kindled amygdaloid seizures

1 reference

https://api.crossref.org/works/10.1016%2FS1043-6618%2895%2980002-6

7 January 2021

The effect of the non-NMDA receptor antagonist GYKI 52466 and NBQX and the competitive NMDA receptor antagonist D-CPPene on the development of amygdala kindling and on amygdala-kindled seizures

1 reference

https://api.crossref.org/works/10.1016%2FS1043-6618%2895%2980002-6

7 January 2021

The NMDA antagonist MK-801 suppresses behavioral seizures, augments afterdischarges, but does not block development of perforant path kindling

1 reference

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7 January 2021

Effects of antiepileptics on both behavioral and electrographic seizure patterns induced by maximal electroshock in rats

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7 January 2021

The effects of intrahippocampal ibotenic acid and their blockade by (?) 2-amino-7-phosphonoheptanoic acid: Morphological and electroencephalographical analysis

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7 January 2021

D-aminaphosphonovalerate is 100-fold more powerful than D-alpha-aminoadipate in blocking N-methylaspartate neurotoxicity

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7 January 2021

Ketamine and MK-801 prevent degeneration of thalamic neurons induced by focal cortical seizures

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7 January 2021

MK-801 protects against neuronal injury induced by electrical stimulation

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7 January 2021

Kainic acid neurotoxicity in the goldfish optic tectum. No protection by the NMDA receptor antagonist MK801 and partial protection by abolition of a tectal excitatory input

1 reference

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7 January 2021

7-Chlorokynurenate prevents NMDA-induced and kainate-induced striatal lesions

1 reference

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7 January 2021

Kainate-induced degeneration of neostriatal neurons: dependency upon corticostriatal tract

1 reference

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7 January 2021

Kainic acid neurotoxicity toward hippocampal formation: dependence on specific excitatory pathways

1 reference

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7 January 2021

CGS-19755 is neuroprotective during repetitive ischemia: this effect is significantly enhanced when combined with hypothermia

1 reference

https://api.crossref.org/works/10.1016%2FS1043-6618%2895%2980002-6

7 January 2021

Pre- and post-treatment with MK-801 but not pretreatment alone reduces neocortical damage after focal cerebral ischemia in the rat.

1 reference

https://api.crossref.org/works/10.1016%2FS1043-6618%2895%2980002-6

7 January 2021

AMPA, but not NMDA, receptor antagonism is neuroprotective in gerbil global ischaemia, even when delayed 24 h

1 reference

https://api.crossref.org/works/10.1016%2FS1043-6618%2895%2980002-6

7 January 2021

Delayed neuronal death in the gerbil hippocampus following ischemia

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https://api.crossref.org/works/10.1016%2FS1043-6618%2895%2980002-6

7 January 2021

Hippocampal unit activity after transient cerebral ischemia in rats

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https://api.crossref.org/works/10.1016%2FS1043-6618%2895%2980002-6

7 January 2021

Postischemic synaptic physiology in area CA1 of the gerbil hippocampus studied in vitro

1 reference

https://api.crossref.org/works/10.1016%2FS1043-6618%2895%2980002-6

7 January 2021

Selective neuron loss after cerebral ischemia in the rat: possible role of transmitter glutamate

1 reference

https://api.crossref.org/works/10.1016%2FS1043-6618%2895%2980002-6

7 January 2021

The effect of NMDA, AMPA/kainate, and calcium channel antagonists on traumatic cortical neuronal injury in culture

1 reference

https://api.crossref.org/works/10.1016%2FS1043-6618%2895%2980002-6

7 January 2021

Effects of calcium antagonists on hypoxic and NMDA injury in rat hippocampal slices

1 reference

https://api.crossref.org/works/10.1016%2FS1043-6618%2895%2980002-6

7 January 2021

NMDA antagonists increase recovery of evoked potentials from slices of rat olfactory cortex after anoxia

1 reference

https://api.crossref.org/works/10.1016%2FS1043-6618%2895%2980002-6

7 January 2021

Effects of adenosinergic drugs on hypoxia-induced electrophysiological changes in rat hippocampal slices

1 reference

https://api.crossref.org/works/10.1016%2FS1043-6618%2895%2980002-6

7 January 2021

7-Chlorokynurenate Ameliorates Neuronal Injury Mediated by HIV Envelope Protein gp120 in Rodent Retinal Cultures

1 reference

https://api.crossref.org/works/10.1016%2FS1043-6618%2895%2980002-6

7 January 2021

Calcium-mediated neurotoxicity: relationship to specific channel types and role in ischemic damage

1 reference

https://api.crossref.org/works/10.1016%2FS1043-6618%2895%2980002-6

7 January 2021

MK-801, an N-methyl-D-aspartate receptor antagonist, blocks quinolinic acid-induced lipid peroxidation in rat corpus striatum

1 reference

https://api.crossref.org/works/10.1016%2FS1043-6618%2895%2980002-6

7 January 2021

Effects of taurine and ketamine on bovine retinal membrane lipid peroxidation

1 reference

https://api.crossref.org/works/10.1016%2FS1043-6618%2895%2980002-6

7 January 2021

Protective actions of 21-aminosteroids and MK-801 on hypoxia-induced electrophysiological changes in rat hippocampal slices

1 reference

https://api.crossref.org/works/10.1016%2FS1043-6618%2895%2980002-6

7 January 2021

21-Aminosteroids attenuate excitotoxic neuronal injury in cortical cell cultures

1 reference

https://api.crossref.org/works/10.1016%2FS1043-6618%2895%2980002-6

7 January 2021

The role of glutamate neurotoxicity in hypoxic-ischemic neuronal death

1 reference

https://api.crossref.org/works/10.1016%2FS1043-6618%2895%2980002-6

7 January 2021

Neuronal vacuolization and necrosis induced by the noncompetitive N-methyl-D-aspartate (NMDA) antagonist MK(+)801 (dizocilpine maleate): a light and electron microscopic evaluation of the rat retrosplenial cortex

1 reference

https://api.crossref.org/works/10.1016%2FS1043-6618%2895%2980002-6

7 January 2021

MK-801 and ketamine induce heat shock protein HSP72 in injured neurons in posterior cingulate and retrosplenial cortex

1 reference

https://api.crossref.org/works/10.1016%2FS1043-6618%2895%2980002-6

7 January 2021

Behavioural and electroencephalographic effects of excitatory amino acid antagonists and sigma opiate/phencyclidine-like compounds in rats

1 reference

https://api.crossref.org/works/10.1016%2FS1043-6618%2895%2980002-6

7 January 2021

Behavioural and electroencephalographic interactions between haloperidol and PCP/sigma ligands in the rat

1 reference

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7 January 2021

Different capability of N-methyl-D-aspartate antagonists to elicit EEG and behavioural phencyclidine-like effects in rats

1 reference

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7 January 2021

NE-100, a novel sigma receptor ligand: effect on phencyclidine-induced behaviors in rats, dogs and monkeys

1 reference

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7 January 2021

Dizocilpine (MK-801), ketamine and phencyclidine: low doses affect brain field potentials in the freely moving rat in the same way as activation of dopaminergic transmission

1 reference

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7 January 2021

NMDA receptors and in vivo dopamine release in the nucleus accumbens and caudatus

1 reference

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7 January 2021

Attenuation of hippocampal inhibition by a NMDA (N-methyl-D-aspartate) receptor antagonist

1 reference

https://api.crossref.org/works/10.1016%2FS1043-6618%2895%2980002-6

7 January 2021

The noncompetitive N-methyl-D-aspartate antagonists, MK-801, phencyclidine and ketamine, increase the potency of general anesthetics

1 reference

https://api.crossref.org/works/10.1016%2FS1043-6618%2895%2980002-6

7 January 2021

The contribution of excitatory amino acids to central sensitization and persistent nociception after formalin-induced tissue injury

1 reference

https://api.crossref.org/works/10.1016%2FS1043-6618%2895%2980002-6

7 January 2021

Inhibition of Morphine Tolerance and Dependence by the NMDA Receptor Antagonist MK-801

1 reference

https://api.crossref.org/works/10.1016%2FS1043-6618%2895%2980002-6

7 January 2021

Inhibition of opiate tolerance by non-competitive N-methyl-D-aspartate receptor antagonists

1 reference

https://api.crossref.org/works/10.1016%2FS1043-6618%2895%2980002-6

7 January 2021

Selective impairment of learning and blockade of long-term potentiation by an N-methyl-D-aspartate receptor antagonist, AP5

1 reference

https://api.crossref.org/works/10.1016%2FS1043-6618%2895%2980002-6

7 January 2021

Anti-parkinsonian agents are phencyclidine agonists and N-methyl-aspartate antagonists

1 reference

https://api.crossref.org/works/10.1016%2FS1043-6618%2895%2980002-6

7 January 2021

Anticataleptic effects of the N-methyl-D-aspartate antagonist MK-801 in rats

1 reference

https://api.crossref.org/works/10.1016%2FS1043-6618%2895%2980002-6

7 January 2021

NMDA receptor antagonists inhibit catalepsy induced by either dopamine D1 or D2 receptor antagonists

1 reference

https://api.crossref.org/works/10.1016%2FS1043-6618%2895%2980002-6

7 January 2021

NMDA antagonists potentiate antiparkinsonian actions of L-dopa in monoamine-depleted rats

1 reference

https://api.crossref.org/works/10.1016%2FS1043-6618%2895%2980002-6

7 January 2021

Competitive NMDA antagonists enhance the catalepsy induced by delta 9-tetrahydrocannabinol in mice

1 reference

https://api.crossref.org/works/10.1016%2FS1043-6618%2895%2980002-6

7 January 2021

Effects of the 1-amino-adamantanes at the MK-801-binding site of the NMDA-receptor-gated ion channel: a human postmortem brain study

1 reference

https://api.crossref.org/works/10.1016%2FS1043-6618%2895%2980002-6

7 January 2021

Memantine is a potent blocker of N-methyl-D-aspartate (NMDA) receptor channels

1 reference

https://api.crossref.org/works/10.1016%2FS1043-6618%2895%2980002-6

7 January 2021

Heteromeric NMDA receptors: molecular and functional distinction of subtypes

1 reference

https://api.crossref.org/works/10.1016%2FS1043-6618%2895%2980002-6

7 January 2021

Some central effects of CGP 37849 and CGP 39551, the competitive NMDA receptor antagonists: potential antiparkinsonian activity

1 reference

https://api.crossref.org/works/10.1016%2FS1043-6618%2895%2980002-6

7 January 2021

Different capability of N-methyl-D-aspartate antagonists to affect locomotor/exploratory activity of mice in a computerized on-line open field test

1 reference

https://api.crossref.org/works/10.1016%2FS1043-6618%2895%2980002-6

7 January 2021

Antiepileptogenic action of 7-chlorokynurenic acid on amygdala kindling of rats

1 reference

https://api.crossref.org/works/10.1016%2FS1043-6618%2895%2980002-6

7 January 2021

Effects of some excitatory amino acid antagonists on imipenem-induced seizures in DBA/2 mice.

1 reference

https://api.crossref.org/works/10.1016%2FS1043-6618%2895%2980002-6

7 January 2021

An electrophysiological study on the common antitussive drug dextromethorphan in hippocampal slices in the rat.

1 reference

https://api.crossref.org/works/10.1016%2FS1043-6618%2895%2980002-6

7 January 2021

Non-opioid antitussives potentiate some behavioural and EEG effects of N-methyl-D-aspartate channel blockers

1 reference

https://api.crossref.org/works/10.1016%2FS1043-6618%2895%2980002-6

7 January 2021

Nucleus accumbens NMDA antagonist decreases locomotor activity produced by cocaine, heroin or accumbens dopamine, but not caffeine

1 reference

https://api.crossref.org/works/10.1016%2FS1043-6618%2895%2980002-6

7 January 2021

Neuroprotection by N-methyl-D-aspartate antagonists in focal cerebral ischemia is dependent on continued maintenance dosing

1 reference

https://api.crossref.org/works/10.1016%2FS1043-6618%2895%2980002-6

7 January 2021

The involvement of excitatory amino acids in neocortical epileptogenesis: NMDA and non-NMDA receptors

1 reference

https://api.crossref.org/works/10.1016%2FS1043-6618%2895%2980002-6

7 January 2021

Inhibition of K+-evoked [3H]D-aspartate release and neuronal calcium influx by verapamil, diltiazem and dextromethorphan: evidence for non-L/non-N voltage-sensitive calcium channels

1 reference

https://api.crossref.org/works/10.1016%2FS1043-6618%2895%2980002-6

7 January 2021

Diversified electrophysiological properties of morphinan drugs in rats

1 reference

https://api.crossref.org/works/10.1016%2FS1043-6618%2895%2980002-6

7 January 2021

Influence of morphine and cyclazocine on the cortical epileptic foci in rabbits

1 reference

https://api.crossref.org/works/10.1016%2FS1043-6618%2895%2980002-6

7 January 2021

MK-801, but not drugs acting at strychnine-insensitive glycine receptors, attenuate methamphetamine nigrostriatal toxicity

1 reference

https://api.crossref.org/works/10.1016%2FS1043-6618%2895%2980002-6

7 January 2021

The glycine/NMDA receptor antagonist, R-(+)-HA-966, blocks activation of the mesolimbic dopaminergic system induced by phencyclidine and dizocilpine (MK-801) in rodents

1 reference

https://api.crossref.org/works/10.1016%2FS1043-6618%2895%2980002-6

7 January 2021

Felbamate displays in vitro antiepileptic effects as a broad spectrum excitatory amino acid receptor antagonist

1 reference

https://api.crossref.org/works/10.1016%2FS1043-6618%2895%2980002-6

7 January 2021

Neuroprotective effect of felbamate after kainic acid-induced status epilepticus.

1 reference

https://api.crossref.org/works/10.1016%2FS1043-6618%2895%2980002-6

7 January 2021

The glycine/NMDA receptor partial agonist D-cycloserine blocks kainate-induced seizures in rats. Comparison with MK-801 and diazepam

1 reference

https://api.crossref.org/works/10.1016%2FS1043-6618%2895%2980002-6

7 January 2021

Anticonvulsant activity of a novel NMDA/glycine site antagonist, MDL 104,653, against kindled and sound-induced seizures

1 reference

https://api.crossref.org/works/10.1016%2FS1043-6618%2895%2980002-6

7 January 2021

The non-NMDA glutamate receptor antagonist GYKI 52466 counteracts locomotor stimulation and anticataleptic activity induced by the NMDA antagonist dizocilpine

1 reference

https://api.crossref.org/works/10.1016%2FS1043-6618%2895%2980002-6

7 January 2021

Prospects for clinically tolerated NMDA antagonists: open-channel blockers and alternative redox states of nitric oxide

1 reference

https://api.crossref.org/works/10.1016%2FS1043-6618%2895%2980002-6

7 January 2021

Glutamate receptor antagonists for neuroleptic malignant syndrome and akinetic hyperthermic parkinsonian crisis

1 reference

https://api.crossref.org/works/10.1016%2FS1043-6618%2895%2980002-6

7 January 2021

Ketamine activates psychosis and alters limbic blood flow in schizophrenia.

1 reference

https://api.crossref.org/works/10.1016%2FS1043-6618%2895%2980002-6

7 January 2021

10.1016/S1043-6618(95)80002-6

Identifiers

DOI

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25 September 2017

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