Identification of microglial signal transduction pathways mediating a neurotoxic response to amyloidogenic fragments of beta-amyloid and prion proteins (Q40977784)

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scientific article published on February 1999

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English	Identification of microglial signal transduction pathways mediating a neurotoxic response to amyloidogenic fragments of beta-amyloid and prion proteins	scientific article published on February 1999

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scholarly article

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Europe PubMed Central

PubMed publication ID

25 September 2017

Identification of microglial signal transduction pathways mediating a neurotoxic response to amyloidogenic fragments of beta-amyloid and prion proteins (English)

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Europe PubMed Central

PubMed publication ID

25 September 2017

prion protein family

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author name string

C K Combs

1

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Europe PubMed Central

PubMed publication ID

25 September 2017

D E Johnson

2

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Europe PubMed Central

PubMed publication ID

25 September 2017

S B Cannady

3

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Europe PubMed Central

PubMed publication ID

25 September 2017

T M Lehman

4

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Europe PubMed Central

PubMed publication ID

25 September 2017

G E Landreth

5

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Europe PubMed Central

PubMed publication ID

25 September 2017

language of work or name

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publication date

1 February 1999

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Europe PubMed Central

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25 September 2017

Journal of Neuroscience

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Europe PubMed Central

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25 September 2017

19

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Europe PubMed Central

PubMed publication ID

25 September 2017

3

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Europe PubMed Central

PubMed publication ID

25 September 2017

928-939

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Europe PubMed Central

PubMed publication ID

25 September 2017

Identification of the major tyrosine kinase substrate in signaling complexes formed after engagement of Fc gamma receptors

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https://pubmed.ncbi.nlm.nih.gov/9920656

12 December 2020

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Morphogenesis of amyloid plaques in 87V murine scrapie

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https://pubmed.ncbi.nlm.nih.gov/9920656

12 December 2020

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beta-Amyloid protein-dependent nitric oxide production from microglial cells and neurotoxicity

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https://pubmed.ncbi.nlm.nih.gov/9920656

12 December 2020

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An L1-like molecule, the 8D9 antigen, is a potent substrate for neurite extension

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https://pubmed.ncbi.nlm.nih.gov/9920656

12 December 2020

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Relationship of microglia and scrapie amyloid-immunoreactive plaques in kuru, Creutzfeldt-Jakob disease and Gerstmann-Sträussler syndrome

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https://pubmed.ncbi.nlm.nih.gov/9920656

12 December 2020

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Regulation of Phagocytosis and [Ca 2+ ] i Flux by Distinct Regions of an Fc Receptor

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https://pubmed.ncbi.nlm.nih.gov/9920656

12 December 2020

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Chelerythrine is a potent and specific inhibitor of protein kinase C.

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https://pubmed.ncbi.nlm.nih.gov/9920656

12 December 2020

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Stimulation of tyrosine phosphorylation and calcium mobilization by Fc gamma receptor cross-linking. Regulation by the phosphotyrosine phosphatase CD45.

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https://pubmed.ncbi.nlm.nih.gov/9920656

12 December 2020

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Microglia in degenerative neurological disease.

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https://pubmed.ncbi.nlm.nih.gov/9920656

12 December 2020

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Nonsteroidal anti-inflammatory drug use and Alzheimer-type pathology in aging

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https://pubmed.ncbi.nlm.nih.gov/9920656

12 December 2020

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Synthetic peptides homologous to prion protein residues 106-147 form amyloid-like fibrils in vitro

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https://pubmed.ncbi.nlm.nih.gov/9920656

12 December 2020

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Channel formation by a neurotoxic prion protein fragment

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https://pubmed.ncbi.nlm.nih.gov/9920656

12 December 2020

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Neurotoxicity of a prion protein fragment

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https://pubmed.ncbi.nlm.nih.gov/9920656

12 December 2020

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Physical and functional association of Src-related protein tyrosine kinases with Fc gamma RII in monocytic THP-1 cells

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https://pubmed.ncbi.nlm.nih.gov/9920656

12 December 2020

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Anti‐inflammatory agents as a therapeutic approach to Alzheimer's disease

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https://pubmed.ncbi.nlm.nih.gov/9920656

12 December 2020

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Pharmacologic differentiation between inositol-1,4,5-trisphosphate-induced Ca2+ release and Ca2+- or caffeine-induced Ca2+ release from intracellular membrane systems.

1 reference

https://pubmed.ncbi.nlm.nih.gov/9920656

12 December 2020

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1,25(OH)2 vitamin D3 activates PKC-alpha in Caco-2 cells: a mechanism to limit secosteroid-induced rise in [Ca2+]i

1 reference

https://pubmed.ncbi.nlm.nih.gov/9920656

12 December 2020

based on heuristic

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Characterization of the microglial response in murine scrapie

1 reference

https://pubmed.ncbi.nlm.nih.gov/9920656

12 December 2020

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Evidence that production and release of amyloid beta-protein involves the endocytic pathway

1 reference

https://pubmed.ncbi.nlm.nih.gov/9920656

12 December 2020

based on heuristic

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Paxillin is tyrosine-phosphorylated by and preferentially associates with the calcium-dependent tyrosine kinase in rat liver epithelial cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/9920656

12 December 2020

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Risk of Alzheimer's disease and duration of NSAID use.

1 reference

https://pubmed.ncbi.nlm.nih.gov/9920656

12 December 2020

based on heuristic

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Senile plaques stimulate microglia to release a neurotoxin found in Alzheimer brain

1 reference

https://pubmed.ncbi.nlm.nih.gov/9920656

12 December 2020

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Scrapie prion proteins are synthesized in neurons

1 reference

https://pubmed.ncbi.nlm.nih.gov/9920656

12 December 2020

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The precursor of Alzheimer's disease amyloid A4 protein resembles a cell-surface receptor

1 reference

https://pubmed.ncbi.nlm.nih.gov/9920656

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Evidence for synthesis of scrapie prion proteins in the endocytic pathway

1 reference

https://pubmed.ncbi.nlm.nih.gov/9920656

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Microassays for superoxide and hydrogen peroxide production and nitroblue tetrazolium reduction using an enzyme immunoassay microplate reader

1 reference

https://pubmed.ncbi.nlm.nih.gov/9920656

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding

1 reference

https://pubmed.ncbi.nlm.nih.gov/9920656

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Nonsteroidal anti-inflammatory drugs in Alzheimer's disease.

1 reference

https://pubmed.ncbi.nlm.nih.gov/9920656

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Anti-inflammatory drugs in the fight against Alzheimer's disease

1 reference

https://pubmed.ncbi.nlm.nih.gov/9920656

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Can deposition of amyloid be prevented in Alzheimer's disease?

1 reference

https://pubmed.ncbi.nlm.nih.gov/9920656

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

A comparative immunohistochemical study of Kuru and senile plaques with a special reference to glial reactions at various stages of amyloid plaque formation

1 reference

https://pubmed.ncbi.nlm.nih.gov/9920656

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

PD 098059 is a specific inhibitor of the activation of mitogen-activated protein kinase kinase in vitro and in vivo

1 reference

https://pubmed.ncbi.nlm.nih.gov/9920656

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Differential regulation by beta-amyloid peptides of intracellular free Ca2+ concentration in cultured rat microglia

1 reference

https://pubmed.ncbi.nlm.nih.gov/9920656

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

beta-Amyloid converts an acute phase injury response to chronic injury responses

1 reference

https://pubmed.ncbi.nlm.nih.gov/9920656

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Increase of intracellular free Ca2+ in microglia activated by prion protein fragment

1 reference

https://pubmed.ncbi.nlm.nih.gov/9920656

12 December 2020

based on heuristic

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PrP deposition, microglial activation, and neuronal apoptosis in murine scrapie

1 reference

https://pubmed.ncbi.nlm.nih.gov/9920656

12 December 2020

based on heuristic

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beta-amyloid protein enhances macrophage production of oxygen free radicals and glutamate

1 reference

https://pubmed.ncbi.nlm.nih.gov/9920656

12 December 2020

based on heuristic

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Structural studies of the scrapie prion protein using mass spectrometry and amino acid sequencing.

1 reference

https://pubmed.ncbi.nlm.nih.gov/9920656

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

beta-Amyloid-induced IL-1 beta release from an activated human monocyte cell line is calcium- and G-protein-dependent

1 reference

https://pubmed.ncbi.nlm.nih.gov/9920656

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Purification and structural studies of a major scrapie prion protein

1 reference

https://pubmed.ncbi.nlm.nih.gov/9920656

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Repeated probing of western blots obtained from coomassie brilliant blue-stained or unstained polyacrylamide gels.

1 reference

https://pubmed.ncbi.nlm.nih.gov/9920656

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

A novel pathway for the activation of phospholipase D by P2z purinergic receptors in BAC1.2F5 macrophages

1 reference

https://pubmed.ncbi.nlm.nih.gov/9920656

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Differential regulation of IL-1 alpha and TNF alpha release from immortalized murine microglia (BV-2).

1 reference

https://pubmed.ncbi.nlm.nih.gov/9920656

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Cell death in prion disease.

1 reference

https://pubmed.ncbi.nlm.nih.gov/9920656

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The unique domain as the site on Lyn kinase for its constitutive association with the high affinity receptor for IgE

1 reference

https://pubmed.ncbi.nlm.nih.gov/9920656

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Tyrosine phosphorylation and association of Syk with Fc gamma RII in monocytic THP-1 cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/9920656

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Selective inhibition of protein kinase C isozymes by the indolocarbazole Gö 6976.

1 reference

https://pubmed.ncbi.nlm.nih.gov/9920656

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Ionic effects of the Alzheimer's disease beta-amyloid precursor protein and its metabolic fragments

1 reference

https://pubmed.ncbi.nlm.nih.gov/9920656

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Interaction of Alzheimer beta-amyloid peptide with the human monocytic cell line THP-1 results in a protein kinase C-dependent secretion of tumor necrosis factor-alpha

1 reference

https://pubmed.ncbi.nlm.nih.gov/9920656

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Protein tyrosine kinase PYK2 involved in Ca(2+)-induced regulation of ion channel and MAP kinase functions

1 reference

https://pubmed.ncbi.nlm.nih.gov/9920656

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Microtubule integrity regulates src-like and extracellular signal-regulated kinase activities in human pro-monocytic cells. Importance for interleukin-1 production

1 reference

https://pubmed.ncbi.nlm.nih.gov/9920656

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

A calcium-dependent tyrosine kinase splice variant in human monocytes. Activation by a two-stage process involving adherence and a subsequent intracellular signal

1 reference

https://pubmed.ncbi.nlm.nih.gov/9920656

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Discovery of a novel, potent, and Src family-selective tyrosine kinase inhibitor. Study of Lck- and FynT-dependent T cell activation

1 reference

https://pubmed.ncbi.nlm.nih.gov/9920656

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Microglia and prion disease: a review

1 reference

https://pubmed.ncbi.nlm.nih.gov/9920656

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Amyloid fibrils activate tyrosine kinase-dependent signaling and superoxide production in microglia.

1 reference

https://pubmed.ncbi.nlm.nih.gov/9920656

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Intracellular calcium homeostasis

1 reference

https://pubmed.ncbi.nlm.nih.gov/9920656

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Reactive microglia in Creutzfeldt-Jakob disease

1 reference

https://pubmed.ncbi.nlm.nih.gov/9920656

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Arthritis and anti-inflammatory agents as possible protective factors for Alzheimer's disease: a review of 17 epidemiologic studies

1 reference

https://pubmed.ncbi.nlm.nih.gov/9920656

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Predicted alpha-helical regions of the prion protein when synthesized as peptides form amyloid

1 reference

https://pubmed.ncbi.nlm.nih.gov/9920656

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Frequency of stages of Alzheimer-related lesions in different age categories

1 reference

https://pubmed.ncbi.nlm.nih.gov/9920656

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

A critical role for Syk in signal transduction and phagocytosis mediated by Fcgamma receptors on macrophages

1 reference

https://pubmed.ncbi.nlm.nih.gov/9920656

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

beta-Amyloid fibrils activate parallel mitogen-activated protein kinase pathways in microglia and THP1 monocytes.

1 reference

https://pubmed.ncbi.nlm.nih.gov/9920656

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Interactions of Dihydroxybenzenes with the Ca2+-ATPase: Separate Binding Sites for Dihydroxybenzenes and Sesquiterpene Lactones

1 reference

https://pubmed.ncbi.nlm.nih.gov/9920656

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

A cellular gene encodes scrapie PrP 27-30 protein

1 reference

https://pubmed.ncbi.nlm.nih.gov/9920656

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Role of microglia and host prion protein in neurotoxicity of a prion protein fragment

1 reference

https://pubmed.ncbi.nlm.nih.gov/9920656

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Intracellular calcium rise through L-type calcium channels, as molecular mechanism for prion protein fragment 106-126-induced astroglial proliferation.

1 reference

https://pubmed.ncbi.nlm.nih.gov/9920656

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Protein kinase C activation precedes arachidonic acid release during IgG-mediated phagocytosis

1 reference

https://pubmed.ncbi.nlm.nih.gov/9920656

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Correlations among tyrosine phosphorylation of Shc, p72syk, PLC-gamma 1, and [Ca2+]i flux in Fc gamma RIIA signaling

1 reference

https://pubmed.ncbi.nlm.nih.gov/9920656

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Paxillin phosphorylation and association with Lck and Pyk2 in anti-CD3- or anti-CD45-stimulated T cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/9920656

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Lipopolysaccharide-induced gene expression in murine peritoneal macrophages is selectively suppressed by agents that elevate intracellular cAMP.

1 reference

https://pubmed.ncbi.nlm.nih.gov/9920656

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Mechanisms of intercellular calcium signaling in glial cells studied with dantrolene and thapsigargin

1 reference

https://pubmed.ncbi.nlm.nih.gov/9920656

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The inflammatory response system of brain: implications for therapy of Alzheimer and other neurodegenerative diseases

1 reference

https://pubmed.ncbi.nlm.nih.gov/9920656

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Relationship of microglia and astrocytes to amyloid deposits of Alzheimer disease.

1 reference

https://pubmed.ncbi.nlm.nih.gov/9920656

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Amyloid beta-peptide is produced by cultured cells during normal metabolism

1 reference

https://pubmed.ncbi.nlm.nih.gov/9920656

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Tyrosine phosphorylation of phospholipase C-gamma 1 induced by cross-linking of the high-affinity or low-affinity Fc receptor for IgG in U937 cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/9920656

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Ras-dependent mitogen-activated protein kinase activation by G protein-coupled receptors. Convergence of Gi- and Gq-mediated pathways on calcium/calmodulin, Pyk2, and Src kinase

1 reference

https://pubmed.ncbi.nlm.nih.gov/9920656

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Truncated forms of the human prion protein in normal brain and in prion diseases

1 reference

https://pubmed.ncbi.nlm.nih.gov/9920656

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The respiratory burst oxidase

1 reference

https://pubmed.ncbi.nlm.nih.gov/9920656

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Inhibition of mast cell Fc epsilon R1-mediated signaling and effector function by the Syk-selective inhibitor, piceatannol.

1 reference

https://pubmed.ncbi.nlm.nih.gov/9920656

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Evidence for an early inflammatory response in the central nervous system of mice with scrapie.

1 reference

https://pubmed.ncbi.nlm.nih.gov/9920656

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Novel proteinaceous infectious particles cause scrapie

1 reference

https://pubmed.ncbi.nlm.nih.gov/9920656

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Free radicals and phagocytic cells.

1 reference

https://pubmed.ncbi.nlm.nih.gov/9920656

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Optimized survival of hippocampal neurons in B27-supplemented Neurobasal, a new serum-free medium combination

1 reference

https://pubmed.ncbi.nlm.nih.gov/9920656

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Tyrosine phosphorylation of the related adhesion focal tyrosine kinase in megakaryocytes upon stem cell factor and phorbol myristate acetate stimulation and its association with paxillin

1 reference

https://pubmed.ncbi.nlm.nih.gov/9920656

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Molecular characteristics of a protease-resistant, amyloidogenic and neurotoxic peptide homologous to residues 106-126 of the prion protein

1 reference

https://pubmed.ncbi.nlm.nih.gov/9920656

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Tyrosine phosphorylation systems in Alzheimer's disease pathology

1 reference

https://pubmed.ncbi.nlm.nih.gov/9920656

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Inhibitors of membrane transport system for organic anions block fura-2 excretion from PC12 and N2A cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/9920656

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Amyloids beta40 and beta42 are generated intracellularly in cultured human neurons and their secretion increases with maturation

1 reference

https://pubmed.ncbi.nlm.nih.gov/9920656

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

PubMed publication ID

1 reference

Europe PubMed Central

PubMed publication ID

25 September 2017

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