Inhibition of H-Ras transformation by the PTEN/MMAC1/TEP1 tumor suppressor gene (Q40896708)

24 September 2017

title

Inhibition of H-Ras transformation by the PTEN/MMAC1/TEP1 tumor suppressor gene (English)

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24 September 2017

T Tolkacheva

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24 September 2017

A M Chan

series ordinal

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24 September 2017

language of work or name

English

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publication date

1 February 2000

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24 September 2017

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24 September 2017

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24 September 2017

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24 September 2017

page(s)

680-689

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New insights into tumor suppression: PTEN suppresses tumor formation by restraining the phosphoinositide 3-kinase/AKT pathway

24 September 2017

cites work

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https://api.crossref.org/works/10.1038%2FSJ.ONC.1203331

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Phosphotyrosine-dependent activation of Rac-1 GDP/GTP exchange by the vav proto-oncogene product

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Akt is a direct target of the phosphatidylinositol 3-kinase. Activation by growth factors, v-src and v-Ha-ras, in Sf9 and mammalian cells

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Pten is essential for embryonic development and tumour suppression

21 January 2018

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PTEN and inherited hamartoma-cancer syndromes

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The protein kinase encoded by the Akt proto-oncogene is a target of the PDGF-activated phosphatidylinositol 3-kinase

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Growth suppression of glioma cells by PTEN requires a functional phosphatase catalytic domain

21 January 2018

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The tumor-suppressor activity of PTEN is regulated by its carboxyl-terminal region

21 January 2018

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Eukaryotic proteins expressed in Escherichia coli: An improved thrombin cleavage and purification procedure of fusion proteins with glutathione S-transferase

21 January 2018

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Protein kinase B (PKB/Akt) activity is elevated in glioblastoma cells due to mutation of the tumor suppressor PTEN/MMAC.

21 January 2018

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Cdc42 and Rac1 induce integrin-mediated cell motility and invasiveness through PI(3)K

21 January 2018

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PTEN/MMAC1/TEP1 suppresses the tumorigenicity and induces G1 cell cycle arrest in human glioblastoma cells

21 January 2018

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PTEN, a putative protein tyrosine phosphatase gene mutated in human brain, breast, and prostate cancer

21 January 2018

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The tumor suppressor, PTEN/MMAC1, dephosphorylates the lipid second messenger, phosphatidylinositol 3,4,5-trisphosphate

21 January 2018

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PTEN: a tumour suppressor that functions as a phospholipid phosphatase

21 January 2018

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A role for Rac in Tiam1-induced membrane ruffling and invasion

21 January 2018

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Phenotypic analysis of human glioma cells expressing the MMAC1 tumor suppressor phosphatase

21 January 2018

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PTEN: Sometimes Taking It Off Can Be Better than Putting It On

21 January 2018

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The lipid phosphatase activity of PTEN is critical for its tumor supressor function

21 January 2018

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Differential roles of Akt, Rac, and Ral in R-Ras-mediated cellular transformation, adhesion, and survival

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Phosphatases and tumorigenesis

21 January 2018

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Mutation of Pten/Mmac1 in mice causes neoplasia in multiple organ systems

21 January 2018

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Regulation of G1 progression by the PTEN tumor suppressor protein is linked to inhibition of the phosphatidylinositol 3-kinase/Akt pathway

21 January 2018

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Role of phosphoinositide 3-OH kinase in cell transformation and control of the actin cytoskeleton by Ras

21 January 2018

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Phosphatidylinositol-3-OH kinase as a direct target of Ras

21 January 2018

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Recognition of unique carboxyl-terminal motifs by distinct PDZ domains

21 January 2018

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Negative regulation of PKB/Akt-dependent cell survival by the tumor suppressor PTEN

21 January 2018

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Identification of a candidate tumour suppressor gene, MMAC1, at chromosome 10q23.3 that is mutated in multiple advanced cancers

21 January 2018

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Inhibition of cell migration, spreading, and focal adhesions by tumor suppressor PTEN

21 January 2018

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Signals from the Ras, Rac, and Rho GTPases converge on the Pak protein kinase in Rat-1 fibroblasts

21 January 2018

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Increasing complexity of the Ras signaling pathway

21 January 2018

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Transfer of purified herpes virus thymidine kinase gene to cultured mouse cells

21 January 2018

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The PTEN/MMAC1 tumor suppressor phosphatase functions as a negative regulator of the phosphoinositide 3-kinase/Akt pathway

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1203331

21 January 2018

Identifiers

DOI

10.1038/SJ.ONC.1203331

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Dimensions Publication ID

24 September 2017

1050525179

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