Reconstitution of a metabolic pathway with triple-cistronic IRES-containing retroviral vectors for correction of tetrahydrobiopterin deficiency (Q40886880)

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English	Reconstitution of a metabolic pathway with triple-cistronic IRES-containing retroviral vectors for correction of tetrahydrobiopterin deficiency	scientific article

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scholarly article

1 reference

Europe PubMed Central

PubMed publication ID

24 September 2017

Reconstitution of a metabolic pathway with triple-cistronic IRES-containing retroviral vectors for correction of tetrahydrobiopterin deficiency (English)

1 reference

Europe PubMed Central

PubMed publication ID

24 September 2017

1 reference

based on heuristic

inferred from title

metabolic pathway

1 reference

based on heuristic

inferred from title

author name string

Laufs S

1

1 reference

Europe PubMed Central

PubMed publication ID

24 September 2017

Kim SH

2

1 reference

Europe PubMed Central

PubMed publication ID

24 September 2017

Kim S

3

1 reference

Europe PubMed Central

PubMed publication ID

24 September 2017

Blau N

4

1 reference

Europe PubMed Central

PubMed publication ID

24 September 2017

Thöny B

5

1 reference

Europe PubMed Central

PubMed publication ID

24 September 2017

language of work or name

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based on heuristic

inferred from title

publication date

1 January 2000

1 reference

Europe PubMed Central

PubMed publication ID

24 September 2017

Journal of Gene Medicine

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Europe PubMed Central

PubMed publication ID

24 September 2017

2

1 reference

Europe PubMed Central

PubMed publication ID

24 September 2017

1

1 reference

Europe PubMed Central

PubMed publication ID

24 September 2017

22-31

1 reference

Europe PubMed Central

PubMed publication ID

24 September 2017

New tetrahydrobiopterin-dependent systems

1 reference

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21 January 2018

Tetrahydrobiopterin biosynthesis defects examined in cytokine-stimulated fibroblasts.

1 reference

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21 January 2018

GTP-cyclohydrolase-I like immunoreactivity in rat brain

1 reference

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21 January 2018

Hereditary progressive dystonia with marked diurnal fluctuation caused by mutations in the GTP cyclohydrolase I gene

1 reference

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21 January 2018

Chromosomal location of two human genes encoding tetrahydrobiopterin-metabolizing enzymes: 6-pyruvoyl-tetrahydropterin synthase maps to 11q22.3-q23.3, and pterin-4 alpha-carbinolamine dehydratase maps to 10q22

1 reference

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21 January 2018

Human GTP-cyclohydrolase I gene and sepiapterin reductase gene map to region 14q21-q22 and 2p14-p12, respectively, by in situ hybridization

1 reference

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21 January 2018

Chromosomal localization, genomic structure and characterization of the human gene and a retropseudogene for 6-pyruvoyltetrahydropterin synthase

1 reference

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21 January 2018

Decameric GTP cyclohydrolase I forms complexes with two pentameric GTP cyclohydrolase I feedback regulatory proteins in the presence of phenylalanine or of a combination of tetrahydrobiopterin and GTP

1 reference

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21 January 2018

Atomic structure of GTP cyclohydrolase I

1 reference

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21 January 2018

Active site topology and reaction mechanism of GTP cyclohydrolase I

1 reference

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21 January 2018

6-Pyruvoyl tetrahydropterin synthase, an enzyme with a novel type of active site involving both zinc binding and an intersubunit catalytic triad motif; site-directed mutagenesis of the proposed active center, characterization of the metal binding si

1 reference

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21 January 2018

Crystallographic and kinetic investigations on the mechanism of 6-pyruvoyl tetrahydropterin synthase

1 reference

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21 January 2018

Inborn errors of pterin metabolism

1 reference

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21 January 2018

Applications of gene therapy to the CNS.

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21 January 2018

Retrovirus-mediated gene transfer of 6-pyruvoyl-tetrahydropterin synthase corrects tetrahydrobiopterin deficiency in fibroblasts from hyperphenylalaninemic patients

1 reference

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21 January 2018

Retroviral vectors containing putative internal ribosome entry sites: development of a polycistronic gene transfer system and applications to human gene therapy

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21 January 2018

Analysis of mutation in human cells by using an Epstein-Barr virus shuttle system

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21 January 2018

Multiple mRNA forms of human GTP cyclohydrolase I

1 reference

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21 January 2018

Human GTP cyclohydrolase I: only one out of three cDNA isoforms gives rise to the active enzyme

1 reference

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21 January 2018

Human 6-pyruvoyltetrahydropterin synthase: cDNA cloning and heterologous expression of the recombinant enzyme

1 reference

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21 January 2018

A transient three-plasmid expression system for the production of high titer retroviral vectors

1 reference

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21 January 2018

Improved methods of retroviral vector transduction and production for gene therapy

1 reference

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21 January 2018

Dicistronic transcription units for gene expression in mammalian cells

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21 January 2018

Internal ribosome entry sites and dicistronic RNAs in mammalian transgenesis

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Vaccination with irradiated tumor cells engineered to secrete murine granulocyte-macrophage colony-stimulating factor stimulates potent, specific, and long-lasting anti-tumor immunity

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21 January 2018

Construction and characterization of retroviral vectors expressing biologically active human interleukin-12.

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21 January 2018

Tetrahydrobiopterin and total biopterin content of neuroblastoma (N1E-115, N2A) and pheochromocytoma (PC-12) clones and the dependence of catecholamine synthesis on tetrahydrobiopterin concentration in PC-12 cells

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21 January 2018

Vascular inducible nitric oxide synthase gene therapy: requirement for guanosine triphosphate cyclohydrolase I.

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21 January 2018

Tetrahydrobiopterin restores endothelial function in hypercholesterolemia.

1 reference

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21 January 2018

Tetrahydrobiopterin, a cofactor for nitric oxide synthase, produces endothelium-dependent dilation of mouse pial arterioles

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21 January 2018

Metabolic engineering as therapy for inborn errors of metabolism--development of mice with phenylalanine hydroxylase expression in muscle

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21 January 2018

Efficient transfer, integration, and sustained long-term expression of the transgene in adult rat brains injected with a lentiviral vector

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21 January 2018

In vivo gene delivery and stable transduction of nondividing cells by a lentiviral vector

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21 January 2018

Murine PGK-1 promoter drives widespread but not uniform expression in transgenic mice.

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21 January 2018

Structural and Functional Consequences of Mutations in 6-Pyruvoyltetrahydropterin Synthase Causing Hyperphenylalaninemia in Humans

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21 January 2018

Neurochemical effects following peripheral administration of tetrahydropterin derivatives to the hph-1 mouse.

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21 January 2018

Retrovirus-mediated double transduction of the GTPCH and PTPS genes allows 6-pyruvoyltetrahydropterin synthase-deficient human fibroblasts to synthesize and release tetrahydrobiopterin.

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21 January 2018

Analysis of reduced forms of biopterin in biological tissues and fluids

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21 January 2018

Gene therapy in neurology.

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21 January 2018

Continuous systemic secretion of a lysosomal enzyme by genetically modified mouse skin fibroblasts.

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21 January 2018

Tetrahydrobiopterin uptake into rat brain synaptosomes, cultured PC12 cells, and rat striatum

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21 January 2018

Effect of tetrahydrobiopterin on endothelial function in canine middle cerebral arteries

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21 January 2018

Acute amelioration of diabetic endothelial dysfunction with a derivative of the nitric oxide synthase cofactor, tetrahydrobiopterin

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21 January 2018

Identifiers

10.1002/(SICI)1521-2254(200001/02)2:1<22::AID-JGM86>3.0.CO;2-1

1 reference

Europe PubMed Central

PubMed publication ID

24 September 2017

PubMed publication ID

1 reference

Europe PubMed Central

PubMed publication ID

24 September 2017

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