Key role of Shc signaling in the transforming pathway triggered by Ret/ptc2 oncoprotein (Q40795928)

23 September 2017

title

Key role of Shc signaling in the transforming pathway triggered by Ret/ptc2 oncoprotein (English)

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23 September 2017

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23 September 2017

E Mercalli

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23 September 2017

S Ghizzoni

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23 September 2017

E Arighi

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23 September 2017

L Alberti

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23 September 2017

R Sangregorio

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23 September 2017

M T Radice

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23 September 2017

M L Gishizky

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23 September 2017

M G Borrello

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23 September 2017

language of work or name

English

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publication date

1 June 2001

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23 September 2017

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23 September 2017

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23 September 2017

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23 September 2017

page(s)

3475-3485

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Grb2 binding to the different isoforms of Ret tyrosine kinase.

23 September 2017

cites work

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https://api.crossref.org/works/10.1038%2FSJ.ONC.1204462

Identification of Shc docking site on Ret tyrosine kinase

21 January 2018

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https://api.crossref.org/works/10.1038%2FSJ.ONC.1204462

A mutation at tyrosine 1062 in MEN2A-Ret and MEN2B-Ret impairs their transforming activity and association with shc adaptor proteins

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1204462

Signaling complexes and protein-protein interactions involved in the activation of the Ras and phosphatidylinositol 3-kinase pathways by the c-Ret receptor tyrosine kinase.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1204462

Molecular characterization of a thyroid tumor-specific transforming sequence formed by the fusion of ret tyrosine kinase and the regulatory subunit RI alpha of cyclic AMP-dependent protein kinase A

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1204462

The RET proto-oncogene induces apoptosis: a novel mechanism for Hirschsprung disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1204462

The full oncogenic activity of Ret/ptc2 depends on tyrosine 539, a docking site for phospholipase Cgamma

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1204462

Neurturin shares receptors and signal transduction pathways with glial cell line-derived neurotrophic factor in sympathetic neurons

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1204462

GDNF signalling through the Ret receptor tyrosine kinase

21 January 2018

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https://api.crossref.org/works/10.1038%2FSJ.ONC.1204462

Tyrosines outside the kinase core and dimerization are required for the mitogenic activity of RET/ptc2.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1204462

Mitogenic signaling by Ret/ptc2 requires association with enigma via a LIM domain

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1204462

Shc and Enigma are both required for mitogenic signaling by Ret/ptc2.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1204462

Diverse signaling pathways activated by growth factor receptors induce broadly overlapping, rather than independent, sets of genes

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1204462

Papillary thyroid carcinoma oncogene (RET/PTC) alters the nuclear envelope and chromatin structure

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1204462

Tyrosine phosphorylation sites at amino acids 239 and 240 of Shc are involved in epidermal growth factor-induced mitogenic signaling that is distinct from Ras/mitogen-activated protein kinase activation

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1204462

Cell proliferation and apoptosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1204462

Characterization of intracellular signals via tyrosine 1062 in RET activated by glial cell line-derived neurotrophic factor

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1204462

Ret oncogene signal transduction via a IRS-2/PI 3-kinase/PKB and a SHC/Grb-2 dependent pathway: possible implication for transforming activity in NIH3T3 cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1204462

An alternative to SH2 domains for binding tyrosine-phosphorylated proteins

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1204462

Oncogenic RET receptors display different autophosphorylation sites and substrate binding specificities

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1204462

The SH2 and SH3 domain-containing protein GRB2 links receptor tyrosine kinases to ras signaling

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1204462

The p66shc adaptor protein controls oxidative stress response and life span in mammals

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1204462

Persephin, a novel neurotrophic factor related to GDNF and neurturin

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1204462

The Ret Receptor Protein Tyrosine Kinase Associates with the SH2-containing Adapter Protein Grb10

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1204462

Direct association between the Ret receptor tyrosine kinase and the Src homology 2-containing adapter protein Grb7

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1204462

Loss of function effect of RET mutations causing Hirschsprung disease.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1204462

RET mutations in human disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1204462

A novel transforming protein (SHC) with an SH2 domain is implicated in mitogenic signal transduction

21 January 2018

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https://api.crossref.org/works/10.1038%2FSJ.ONC.1204462

Tyrosine kinase receptor-activated signal transduction pathways which lead to oncogenesis.

21 January 2018

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https://api.crossref.org/works/10.1038%2FSJ.ONC.1204462

An epidermal growth factor receptor/ret chimera generates mitogenic and transforming signals: evidence for a ret-specific signaling pathway

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1204462

How receptor tyrosine kinases activate Ras.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1204462

Transforming ability of MEN2A-RET requires activation of the phosphatidylinositol 3-kinase/AKT signaling pathway.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1204462

Catalytic specificity of protein-tyrosine kinases is critical for selective signalling

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1204462

Activation of a novel human transforming gene, ret, by DNA rearrangement

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1204462

Functional receptor for GDNF encoded by the c-ret proto-oncogene

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1204462

Ret-dependent and -independent mechanisms of glial cell line-derived neurotrophic factor signaling in neuronal cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1204462

Tyrosines 1021 and 1009 are phosphorylation sites in the carboxy terminus of the platelet-derived growth factor receptor beta subunit and are required for binding of phospholipase C gamma and a 64-kilodalton protein, respectively

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1204462

Glial cell line-derived neurotrophic factor induces Ret-mediated lamellipodia formation

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1204462

RET alternate splicing influences the interaction of activated RET with the SH2 and PTB domains of Shc, and the SH2 domain of Grb2

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1204462

7 January 2021

Specific motifs recognized by the SH2 domains of Csk, 3BP2, fps/fes, GRB-2, HCP, SHC, Syk, and Vav

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1204462

7 January 2021

Differential Utilization of ShcA Tyrosine Residues and Functional Domains in the Transduction of Epidermal Growth Factor-induced Mitogen-activated Protein Kinase Activation in 293T Cells and Nerve Growth Factor-induced Neurite Outgrowth in PC12 Cells

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1204462

7 January 2021

Specificity of the PTB domain of Shc for beta turn-forming pentapeptide motifs amino-terminal to phosphotyrosine

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1204462

7 January 2021

Identifiers

DOI

10.1038/SJ.ONC.1204462

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Dimensions Publication ID

23 September 2017

1006607863

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