Derepression of Polycomb targets during pancreatic organogenesis allows insulin-producing beta-cells to adopt a neural gene activity program (Q40784127)

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English	Derepression of Polycomb targets during pancreatic organogenesis allows insulin-producing beta-cells to adopt a neural gene activity program	scientific article

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scholarly article

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Europe PubMed Central

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23 September 2017

Derepression of Polycomb targets during pancreatic organogenesis allows insulin-producing beta-cells to adopt a neural gene activity program (English)

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23 September 2017

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Ignasi Moran

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Joris van Arensbergen

1

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23 September 2017

Javier García-Hurtado

2

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23 September 2017

Miguel Angel Maestro

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23 September 2017

Xiaobo Xu

5

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23 September 2017

Mark Van de Casteele

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23 September 2017

Anouchka L Skoudy

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23 September 2017

Matteo Palassini

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23 September 2017

Harry Heimberg

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23 September 2017

publication date

15 April 2010

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23 September 2017

Genome Research

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23 September 2017

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23 September 2017

6

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Europe PubMed Central

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23 September 2017

722-732

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Europe PubMed Central

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23 September 2017

A map of open chromatin in human pancreatic islets

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2877569

24 September 2017

Alternative epigenetic chromatin states of polycomb target genes

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2877569

24 September 2017

Pathways to new beta cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2877569

24 September 2017

Polycomb protein Ezh2 regulates pancreatic beta-cell Ink4a/Arf expression and regeneration in diabetes mellitus.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2877569

24 September 2017

Ezh2 orchestrates gene expression for the stepwise differentiation of tissue-specific stem cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2877569

24 September 2017

TOX3 regulates calcium-dependent transcription in neurons

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2877569

24 September 2017

Genetics and epigenetics: stability and plasticity during cellular differentiation

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2877569

24 September 2017

Ezh1 and Ezh2 maintain repressive chromatin through different mechanisms

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2877569

24 September 2017

An integrated software system for analyzing ChIP-chip and ChIP-seq data

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2877569

24 September 2017

In vivo reprogramming of adult pancreatic exocrine cells to beta-cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2877569

24 September 2017

On the origin of the beta cell

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2877569

24 September 2017

Genome-scale DNA methylation maps of pluripotent and differentiated cells

1 reference

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24 September 2017

Targeted deficiency of the transcriptional activator Hnf1alpha alters subnuclear positioning of its genomic targets

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2877569

24 September 2017

Polycomb complexes and epigenetic states

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2877569

24 September 2017

Genetic programming of liver and pancreas progenitors: lessons for stem-cell differentiation

1 reference

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24 September 2017

Stem cell regulation by polycomb repressors: postponing commitment

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2877569

24 September 2017

Pancreatic endoderm derived from human embryonic stem cells generates glucose-responsive insulin-secreting cells in vivo

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2877569

24 September 2017

Beta cells can be generated from endogenous progenitors in injured adult mouse pancreas

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2877569

24 September 2017

A histone H3 lysine 27 demethylase regulates animal posterior development

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2877569

24 September 2017

Physical exercise-induced hypoglycemia caused by failed silencing of monocarboxylate transporter 1 in pancreatic beta cells

1 reference

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24 September 2017

Genome-wide maps of chromatin state in pluripotent and lineage-committed cells

1 reference

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24 September 2017

Genome-wide mapping of in vivo protein-DNA interactions

1 reference

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24 September 2017

High-resolution profiling of histone methylations in the human genome

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2877569

24 September 2017

Polycomb/Trithorax response elements and epigenetic memory of cell identity

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2877569

24 September 2017

Comparison of sample preparation methods for ChIP-chip assays

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2877569

24 September 2017

The genomic landscape of histone modifications in human T cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2877569

24 September 2017

A bivalent chromatin structure marks key developmental genes in embryonic stem cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2877569

24 September 2017

Control of developmental regulators by Polycomb in human embryonic stem cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2877569

24 September 2017

Polycomb complexes repress developmental regulators in murine embryonic stem cells

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2877569

24 September 2017

TileMap: create chromosomal map of tiling array hybridizations

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24 September 2017

oPOSSUM: identification of over-represented transcription factor binding sites in co-expressed genes

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24 September 2017

Suz12 is essential for mouse development and for EZH2 histone methyltransferase activity

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2877569

24 September 2017

Histone H3 lysine 4 methylation patterns in higher eukaryotic genes

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2877569

24 September 2017

Hnf6 and Tcf2 (MODY5) are linked in a gene network operating in a precursor cell domain of the embryonic pancreas

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2877569

24 September 2017

Polycomb, epigenomes, and control of cell identity

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2877569

24 September 2017

The polycomb-group gene Ezh2 is required for early mouse development

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2877569

24 September 2017

Pax6 regulates the identity of embryonic diencephalic neurons

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2877569

24 September 2017

Chromatin fine structure profiles for a developmentally regulated gene: reorganization of the lysozyme locus before trans-activator binding and gene expression

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2877569

24 September 2017

Pancreatic and duodenal homeobox gene 1 induces expression of insulin genes in liver and ameliorates streptozotocin-induced hyperglycemia

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24 September 2017

neurogenin3 is required for the development of the four endocrine cell lineages of the pancreas

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2877569

24 September 2017

Overexpression of monocarboxylate transporter and lactate dehydrogenase alters insulin secretory responses to pyruvate and lactate in beta cells

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24 September 2017

Heterogeneity in glucose sensitivity among pancreatic beta-cells is correlated to differences in glucose phosphorylation rather than glucose transport.

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2877569

24 September 2017

The cytochemistry and ultrastructure of polypeptide hormone-producing cells of the APUD series and the embryologic, physiologic and pathologic implications of the concept

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24 September 2017

The Neural Crest and the Origin of the Insulin-Producing and Other Gastrointestinal Hormone-Producing Cells

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25 September 2017

Expression of neuronal traits in pancreatic beta cells. Implication of neuron-restrictive silencing factor/repressor element silencing transcription factor, a neuron-restrictive silencer.

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25 September 2017

Transforming growth factor (TGF)beta, fibroblast growth factor (FGF) and retinoid signalling pathways promote pancreatic exocrine gene expression in mouse embryonic stem cells

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17 June 2018

NRSF/REST is required in vivo for repression of multiple neuronal target genes during embryogenesis

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Lineage-specific polycomb targets and de novo DNA methylation define restriction and potential of neuronal progenitors.

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19 August 2018

Functional significance of repressor element 1 silencing transcription factor (REST) target genes in pancreatic beta cells.

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19 August 2018

In vitro generation of insulin-producing beta cells from adult exocrine pancreatic cells

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19 August 2018

The beta-globin nuclear compartment in development and erythroid differentiation

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19 August 2018

The pancreatic beta-cell as a fuel sensor: an electrophysiologist's viewpoint

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19 August 2018

Purification of rat pancreatic B-cells by fluorescence-activated cell sorting

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12 December 2020

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The migration of neural crest cells to the wall of the digestive tract in avian embryo

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https://pubmed.ncbi.nlm.nih.gov/20395405

12 December 2020

based on heuristic

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Towards cell therapy for diabetes

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https://pubmed.ncbi.nlm.nih.gov/20395405

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Tissue collection for systematic phenotyping in the mouse

1 reference

https://pubmed.ncbi.nlm.nih.gov/20395405

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based on heuristic

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No REST for healthy beta cells

1 reference

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Insulitis in human type 1 diabetes

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based on heuristic

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10.1101/GR.101709.109

1 reference

Europe PubMed Central

PMC publication ID

23 September 2017

PMC publication ID

1 reference

Europe PubMed Central

PMC publication ID

23 September 2017

PubMed publication ID

1 reference

Europe PubMed Central

PMC publication ID

23 September 2017

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