p21(Cip1) Promotes cyclin D1 nuclear accumulation via direct inhibition of nuclear export (Q40761763)

23 September 2017

title

p21(Cip1) Promotes cyclin D1 nuclear accumulation via direct inhibition of nuclear export (English)

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23 September 2017

Jodi R Alt

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23 September 2017

Andrew B Gladden

series ordinal

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23 September 2017

J Alan Diehl

series ordinal

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23 September 2017

language of work or name

English

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publication date

20 December 2001

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Journal of Biological Chemistry

23 September 2017

published in

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23 September 2017

volume

277

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23 September 2017

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23 September 2017

page(s)

8517-8523

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How do small GTPase signal transduction pathways regulate cell cycle entry?

23 September 2017

cites work

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Ras links growth factor signaling to the cell cycle machinery via regulation of cyclin D1 and the Cdk inhibitor p27KIP1.

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Cyclin D1 expression is regulated positively by the p42/p44MAPK and negatively by the p38/HOGMAPK pathway.

21 January 2018

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Activated MEK stimulates expression of AP-1 components independently of phosphatidylinositol 3-kinase (PI3-kinase) but requires a PI3-kinase signal To stimulate DNA synthesis

21 January 2018

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Sustained activation of extracellular-signal-regulated kinase 1 (ERK1) is required for the continued expression of cyclin D1 in G1 phase

21 January 2018

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Glycogen synthase kinase-3beta regulates cyclin D1 proteolysis and subcellular localization

21 January 2018

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Cyclin D1 is a nuclear protein required for cell cycle progression in G1

21 January 2018

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Phosphorylation-dependent regulation of cyclin D1 nuclear export and cyclin D1-dependent cellular transformation

21 January 2018

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Differential interaction of the cyclin-dependent kinase (Cdk) inhibitor p27Kip1 with cyclin A-Cdk2 and cyclin D2-Cdk4.

21 January 2018

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New functional activities for the p21 family of CDK inhibitors

21 January 2018

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Cloning of p27Kip1, a cyclin-dependent kinase inhibitor and a potential mediator of extracellular antimitogenic signals

21 January 2018

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The p21(Cip1) and p27(Kip1) CDK 'inhibitors' are essential activators of cyclin D-dependent kinases in murine fibroblasts

21 January 2018

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A Dominant-Negative Cyclin D1 Mutant Prevents Nuclear Import of Cyclin-Dependent Kinase 4 (CDK4) and Its Phosphorylation by CDK-Activating Kinase

21 January 2018

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Quantitative studies of the growth of mouse embryo cells in culture and their development into established lines

21 January 2018

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High-efficiency transformation of mammalian cells by plasmid DNA

21 January 2018

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Colony-stimulating factor 1 regulates novel cyclins during the G1 phase of the cell cycle

21 January 2018

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Site-directed mutant p21 proteins defective in both inhibition of E2F-regulated transcription and disruption of E2F-p130-cyclin-cdk2 complexes

21 January 2018

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A nuclear export signal in hnRNP A1: a signal-mediated, temperature-dependent nuclear protein export pathway

21 January 2018

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Nuclear localization of IkappaB alpha is mediated by the second ankyrin repeat: the IkappaB alpha ankyrin repeats define a novel class of cis-acting nuclear import sequences

21 January 2018

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Cyclin E-CDK2 is a regulator of p27Kip1.

21 January 2018

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p27(Kip1) ubiquitination and degradation is regulated by the SCF(Skp2) complex through phosphorylated Thr187 in p27

21 January 2018

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Ubiquitination of p27 is regulated by Cdk-dependent phosphorylation and trimeric complex formation

21 January 2018

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Phosphorylation at serine 10, a major phosphorylation site of p27(Kip1), increases its protein stability

21 January 2018

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21 January 2018

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Cytoplasmic localization of p21Cip1/WAF1 by Akt-induced phosphorylation in HER-2/neu-overexpressing cells

21 January 2018

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Akt-dependent phosphorylation of p21(Cip1) regulates PCNA binding and proliferation of endothelial cells

21 January 2018

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CDK inhibitors: positive and negative regulators of G1-phase progression

21 January 2018

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21 January 2018

Identifiers

DOI

10.1074/JBC.M108867200

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23 September 2017

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