Insulin-like growth factor I induces MDM2-dependent degradation of p53 via the p38 MAPK pathway in response to DNA damage (Q40747113)

23 September 2017

title

Insulin-like growth factor I induces MDM2-dependent degradation of p53 via the p38 MAPK pathway in response to DNA damage (English)

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23 September 2017

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Derek LeRoith

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23 September 2017

Lisa Héron-Milhavet

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23 September 2017

language of work or name

English

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publication date

27 February 2002

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Journal of Biological Chemistry

23 September 2017

published in

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23 September 2017

volume

277

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23 September 2017

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23 September 2017

page(s)

15600-15606

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Molecular and cellular aspects of the insulin-like growth factor I receptor

23 September 2017

cites work

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Insulin-like growth factor-I (IGF-I) receptor activation rescues UV-damaged cells through a p38 signaling pathway. Potential role of the IGF-I receptor in DNA repair

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21 January 2018

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DNA damage activates p53 through a phosphorylation-acetylation cascade

21 January 2018

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p53-dependent inhibition of cyclin-dependent kinase activities in human fibroblasts during radiation-induced G1 arrest.

21 January 2018

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The central region of Gadd45 is required for its interaction with p21/WAF1

21 January 2018

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The mdm-2 oncogene product forms a complex with the p53 protein and inhibits p53-mediated transactivation

21 January 2018

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Insulin-like growth factor-1 induces Mdm2 and down-regulates p53, attenuating the myocyte renin-angiotensin system and stretch-mediated apoptosis

21 January 2018

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Stabilization of p53 by p14ARF without relocation of MDM2 to the nucleolus.

21 January 2018

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DNA microarrays identification of primary and secondary target genes regulated by p53.

21 January 2018

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Novel INK4 proteins, p19 and p18, are specific inhibitors of the cyclin D-dependent kinases CDK4 and CDK6

21 January 2018

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UV-radiation induces dose-dependent regulation of p53 response and modulates p53-HDM2 interaction in human fibroblasts

21 January 2018

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Nucleo-cytoplasmic shuttling of the hdm2 oncoprotein regulates the levels of the p53 protein via a pathway used by the human immunodeficiency virus rev protein.

21 January 2018

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A leucine-rich nuclear export signal in the p53 tetramerization domain: regulation of subcellular localization and p53 activity by NES masking

21 January 2018

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An intact HDM2 RING-finger domain is required for nuclear exclusion of p53.

21 January 2018

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Association of p19(ARF) with Mdm2 inhibits ubiquitin ligase activity of Mdm2 for tumor suppressor p53.

21 January 2018

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21 January 2018

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Light and dark in chromatin repair: repair of UV-induced DNA lesions by photolyase and nucleotide excision repair

21 January 2018

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Nucleotide excision repair is not required for the antiapoptotic function of insulin-like growth factor 1.

21 January 2018

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Molecular characterization of the human excision repair gene ERCC-1: cDNA cloning and amino acid homology with the yeast DNA repair gene RAD10.

21 January 2018

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Involvement of the Ras/extracellular signal-regulated kinase signalling pathway in the regulation of ERCC-1 mRNA levels by insulin

21 January 2018

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21 January 2018

Identifiers

DOI

10.1074/JBC.M111142200

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23 September 2017

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