Pharmacogenetic phenotyping and genotyping. Present status and future potential. (Q40730354)

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English	Pharmacogenetic phenotyping and genotyping. Present status and future potential.	scientific article

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scholarly article

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Europe PubMed Central

PubMed publication ID

8137598

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:8137598%20AND%20SRC:MED&resulttype=core&format=json

retrieved

25 October 2019

review article

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Europe PubMed Central

title

Pharmacogenetic phenotyping and genotyping. Present status and future potential (English)

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stated in

Europe PubMed Central

PubMed publication ID

8137598

reference URL

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:8137598%20AND%20SRC:MED&resulttype=core&format=json

retrieved

25 October 2019

main subject

genotyping

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based on heuristic

inferred from title

author

Jeff Idle

series ordinal

2

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Europe PubMed Central

PubMed publication ID

8137598

reference URL

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:8137598%20AND%20SRC:MED&resulttype=core&format=json

retrieved

25 October 2019

author name string

F J Gonzalez

series ordinal

1

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Europe PubMed Central

PubMed publication ID

8137598

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:8137598%20AND%20SRC:MED&resulttype=core&format=json

retrieved

25 October 2019

publication date

1 January 1994

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Europe PubMed Central

PubMed publication ID

8137598

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:8137598%20AND%20SRC:MED&resulttype=core&format=json

retrieved

25 October 2019

number of pages

12

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published in

Clinical Pharmacokinetics

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stated in

Europe PubMed Central

PubMed publication ID

8137598

reference URL

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:8137598%20AND%20SRC:MED&resulttype=core&format=json

retrieved

25 October 2019

volume

26

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Europe PubMed Central

PubMed publication ID

8137598

reference URL

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:8137598%20AND%20SRC:MED&resulttype=core&format=json

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25 October 2019

issue

1

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Europe PubMed Central

PubMed publication ID

8137598

reference URL

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:8137598%20AND%20SRC:MED&resulttype=core&format=json

retrieved

25 October 2019

page(s)

59-70

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Europe PubMed Central

PubMed publication ID

8137598

reference URL

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:8137598%20AND%20SRC:MED&resulttype=core&format=json

retrieved

25 October 2019

cites work

Heterogeneity of CYP3A isoforms metabolizing erythromycin and cortisol

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PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/8137598

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12 December 2020

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Evolution of the P450 gene superfamily: animal-plant 'warfare', molecular drive and human genetic differences in drug oxidation

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PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/8137598

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12 December 2020

based on heuristic

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Increase of cytochrome P450IA2 activity by omeprazole: evidence by the 13C-[N-3-methyl]-caffeine breath test in poor and extensive metabolizers of S-mephenytoin

1 reference

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PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/8137598

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12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Genetic polymorphism for human platelet thermostable phenol sulfotransferase (TS PST) activity

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PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/8137598

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12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Genetic and metabolic criteria for the assignment of debrisoquine 4-hydroxylation (cytochrome P4502D6) phenotypes

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PubMed

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https://pubmed.ncbi.nlm.nih.gov/8137598

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12 December 2020

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N-acetyltransferase polymorphism. Comparison of phenotype and genotype in humans

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PubMed

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https://pubmed.ncbi.nlm.nih.gov/8137598

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12 December 2020

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inferred from PubMed ID database lookup

Human thiopurine methyltransferase: molecular cloning and expression of T84 colon carcinoma cell cDNA

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PubMed

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https://pubmed.ncbi.nlm.nih.gov/8137598

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12 December 2020

based on heuristic

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Hereditary differences in the expression of the human glutathione transferase active on trans-stilbene oxide are due to a gene deletion

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PubMed

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https://pubmed.ncbi.nlm.nih.gov/8137598

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12 December 2020

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Cytochrome P-450 hPCN3, a novel cytochrome P-450 IIIA gene product that is differentially expressed in adult human liver. cDNA and deduced amino acid sequence and distinct specificities of cDNA-expressed hPCN1 and hPCN3 for the metabolism of [...]

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PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/8137598

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12 December 2020

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Clinical implications of variable antiarrhythmic drug metabolism

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PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/8137598

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12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Slow omeprazole metabolizers are also poor S-mephenytoin hydroxylators.

1 reference

stated in

PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/8137598

retrieved

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Inheritance of human platelet thermolabile phenol sulfotransferase (TL PST) activity

1 reference

stated in

PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/8137598

retrieved

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Impaired (S)-warfarin metabolism catalysed by the R144C allelic variant of CYP2C9

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PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/8137598

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12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Molecular mechanism of slow acetylation of drugs and carcinogens in humans

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PubMed

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https://pubmed.ncbi.nlm.nih.gov/8137598

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12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Individual variation in the activation and inactivation of metabolic pathways of cyclophosphamide

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PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/8137598

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12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Pharmacogenetics of acute azathioprine toxicity: relationship to thiopurine methyltransferase genetic polymorphism

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PubMed

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https://pubmed.ncbi.nlm.nih.gov/8137598

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12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Cyclosporin toxicity at therapeutic blood levels and cytochrome P-450 IIIA.

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PubMed

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https://pubmed.ncbi.nlm.nih.gov/8137598

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12 December 2020

based on heuristic

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Comparison of a novel thin-layer chromatographic-fluorescence detection method with a spectrofluorometric method for the determination of 7-hydroxycoumarin in human urine

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PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/8137598

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12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Molecular genetics of the flavin-dependent monooxygenases

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PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/8137598

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12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Methyltransferase pharmacogenetics

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PubMed

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https://pubmed.ncbi.nlm.nih.gov/8137598

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12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Individual variability in p-aminobenzoic acid N-acetylation by human N-acetyltransferase (NAT1) of peripheral blood

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PubMed

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https://pubmed.ncbi.nlm.nih.gov/8137598

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12 December 2020

based on heuristic

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Drug reactions enzymes, and biochemical genetics

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PubMed

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https://pubmed.ncbi.nlm.nih.gov/8137598

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12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Molecular genetics of the debrisoquin-sparteine polymorphism

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PubMed

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https://pubmed.ncbi.nlm.nih.gov/8137598

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12 December 2020

based on heuristic

inferred from PubMed ID database lookup

An alternative test for acetylator phenotyping with caffeine.

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PubMed

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https://pubmed.ncbi.nlm.nih.gov/8137598

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12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Timolol metabolism and debrisoquine oxidation polymorphism: a population study

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PubMed

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https://pubmed.ncbi.nlm.nih.gov/8137598

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12 December 2020

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Detection of human DNA mutations with nonradioactive, allele-specific oligonucleotide probes

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PubMed

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https://pubmed.ncbi.nlm.nih.gov/8137598

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12 December 2020

based on heuristic

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[Genetic polymorphism in human drug metabolism].

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PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/8137598

retrieved

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Molecular genetics of the N-acetyltransferases.

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PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/8137598

retrieved

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Characterization of cDNA clones encoding rabbit and human serum paraoxonase: the mature protein retains its signal sequence

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PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/8137598

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12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identification of a new variant CYP2D6 allele lacking the codon encoding Lys-281: possible association with the poor metabolizer phenotype

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PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/8137598

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12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Hydroxylation of chlorzoxazone as a specific probe for human liver cytochrome P-450IIE1

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PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/8137598

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12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Familial pyrimidinemia and pyrimidinuria associated with severe fluorouracil toxicity

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PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/8137598

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12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Nortriptyline and debrisoquine hydroxylations in Ghanaian and Swedish subjects.

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PubMed

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12 December 2020

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Relevance of metabolic polymorphisms to human carcinogenesis: evaluation of epidemiologic evidence

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PubMed

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https://pubmed.ncbi.nlm.nih.gov/8137598

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12 December 2020

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inferred from PubMed ID database lookup

Homozygous deletion of gene for glutathione S-transferase M1 in bladder cancer.

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PubMed

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12 December 2020

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The genetic polymorphism of debrisoquine/sparteine metabolism--clinical aspects

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PubMed

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https://pubmed.ncbi.nlm.nih.gov/8137598

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12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Familial deficiency of dihydropyrimidine dehydrogenase. Biochemical basis for familial pyrimidinemia and severe 5-fluorouracil-induced toxicity

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PubMed

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https://pubmed.ncbi.nlm.nih.gov/8137598

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12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Evidence for a new variant CYP2D6 allele CYP2D6J in a Japanese population associated with lower in vivo rates of sparteine metabolism.

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PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/8137598

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12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Concordance of P450 2D6 (debrisoquine hydroxylase) phenotype and genotype: inability of dextromethorphan metabolic ratio to discriminate reliably heterozygous and homozygous extensive metabolizers

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PubMed

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https://pubmed.ncbi.nlm.nih.gov/8137598

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12 December 2020

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Deficient nifedipine oxidation: a rare inherited trait associated with cystic fibrosis kindreds

1 reference

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PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/8137598

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12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Molecular genetics of human aldehyde dehydrogenase

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PubMed

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12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Genetic risk and carcinogen exposure: a common inherited defect of the carcinogen-metabolism gene glutathione S-transferase M1 (GSTM1) that increases susceptibility to bladder cancer

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PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/8137598

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12 December 2020

based on heuristic

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Genetic variation in response to 6-mercaptopurine for childhood acute lymphoblastic leukaemia

1 reference

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PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/8137598

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12 December 2020

based on heuristic

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Correlation between N-acetyltransferase activity and NAT2 genotype in Chinese males

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PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/8137598

retrieved

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Genetically variable metabolism of antidepressants and neuroleptic drugs in man.

1 reference

stated in

PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/8137598

retrieved

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Determination of CYP1A2 and NAT2 phenotypes in human populations by analysis of caffeine urinary metabolites.

1 reference

stated in

PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/8137598

retrieved

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Molecular basis for the polymorphic forms of human serum paraoxonase/arylesterase: glutamine or arginine at position 191, for the respective A or B allozymes.

1 reference

stated in

PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/8137598

retrieved

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The P450 superfamily: update on new sequences, gene mapping, accession numbers, early trivial names of enzymes, and nomenclature

1 reference

stated in

PubMed

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https://pubmed.ncbi.nlm.nih.gov/8137598

retrieved

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identification of a genetic alteration in the code for bilirubin UDP-glucuronosyltransferase in the UGT1 gene complex of a Crigler-Najjar type I patient

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PubMed

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https://pubmed.ncbi.nlm.nih.gov/8137598

retrieved

12 December 2020

based on heuristic

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Mechanism-based inactivation of human liver microsomal cytochrome P-450 IIIA4 by gestodene

1 reference

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PubMed

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https://pubmed.ncbi.nlm.nih.gov/8137598

retrieved

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Hydroxylation of warfarin by human cDNA-expressed cytochrome P-450: a role for P-4502C9 in the etiology of (S)-warfarin-drug interactions

1 reference

stated in

PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/8137598

retrieved

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Pharmacogenetics of alcohol metabolism and alcoholism

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PubMed

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12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Codeine O-demethylation co-segregates with polymorphic debrisoquine hydroxylation

1 reference

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PubMed

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12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The novel bilirubin/phenol UDP-glucuronosyltransferase UGT1 gene locus: implications for multiple nonhemolytic familial hyperbilirubinemia phenotypes

1 reference

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PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/8137598

retrieved

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Erythromycin breath test as an assay of glucocorticoid-inducible liver cytochromes P-450. Studies in rats and patients

1 reference

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PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/8137598

retrieved

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Variability in nifedipine pharmacokinetics and dynamics: a new oxidation polymorphism in man

1 reference

stated in

PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/8137598

retrieved

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Tolbutamide and mephenytoin hydroxylation by human cytochrome P450s in the CYP2C subfamily

1 reference

stated in

PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/8137598

retrieved

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Phenotypically deficient urinary elimination of carboxyphosphamide after cyclophosphamide administration to cancer patients

1 reference

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PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/8137598

retrieved

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Variability of acetaminophen metabolism in Caucasians and Orientals

1 reference

stated in

PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/8137598

retrieved

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Debrisoquine/sparteine hydroxylation genotype and phenotype: analysis of common mutations and alleles of CYP2D6 in a European population

1 reference

stated in

PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/8137598

retrieved

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Role of human cytochrome P-450 IIE1 in the oxidation of many low molecular weight cancer suspects

1 reference

stated in

PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/8137598

retrieved

12 December 2020

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The pharmacogenetics of chemical carcinogenesis

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PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/8137598

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12 December 2020

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Identifiers

DOI

10.2165/00003088-199426010-00005

1 reference

stated in

Europe PubMed Central

PubMed publication ID

8137598

reference URL

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:8137598%20AND%20SRC:MED&resulttype=core&format=json

retrieved

25 October 2019

Dimensions Publication ID

1000823895

0 references

PubMed publication ID

8137598

1 reference

stated in

Europe PubMed Central

PubMed publication ID

8137598

reference URL

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:8137598%20AND%20SRC:MED&resulttype=core&format=json

retrieved

25 October 2019

 

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