The p66Shc longevity gene is silenced through epigenetic modifications of an alternative promoter (Q40738889)

23 September 2017

title

The p66Shc longevity gene is silenced through epigenetic modifications of an alternative promoter (English)

1 reference

23 September 2017

0 references

1 reference

23 September 2017

Lucilla Luzi

0 references

Sonia Pacini

1 reference

23 September 2017

Cosima T Baldari

series ordinal

1 reference

23 September 2017

Pier Giuseppe Pelicci

series ordinal

1 reference

23 September 2017

language of work or name

English

0 references

publication date

10 April 2002

1 reference

Journal of Biological Chemistry

23 September 2017

published in

1 reference

23 September 2017

volume

277

1 reference

23 September 2017

1 reference

23 September 2017

page(s)

22370-22376

1 reference

Evolution of Shc functions from nematode to human

23 September 2017

cites work

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M200280200

Association of the Shc and Grb2/Sem5 SH2-containing proteins is implicated in activation of the Ras pathway by tyrosine kinases

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M200280200

The SH2 and SH3 domains of mammalian Grb2 couple the EGF receptor to the Ras activator mSos1

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M200280200

A novel transforming protein (SHC) with an SH2 domain is implicated in mitogenic signal transduction

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M200280200

Opposite effects of the p52shc/p46shc and p66shc splicing isoforms on the EGF receptor-MAP kinase-fos signalling pathway.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M200280200

The 66-kDa Shc Isoform Is a Negative Regulator of the Epidermal Growth Factor-stimulated Mitogen-activated Protein Kinase Pathway

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M200280200

The p66shc adaptor protein controls oxidative stress response and life span in mammals

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M200280200

Emerging roles for SH2/PTB-containing Shc adaptor proteins in the developing mammalian brain

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M200280200

Expression and activation of SH2/PTB-containing ShcA adaptor protein reflects the pattern of neurogenesis in the mammalian brain

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M200280200

Shc signaling in differentiating neural progenitor cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M200280200

p66Shc isoform down-regulated and not required for HER-2/neu signaling pathway in human breast cancer cell lines with HER-2/neu overexpression

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M200280200

Constitutively tyrosine phosphorylated p52 Shc in breast cancer cells: correlation with ErbB2 and p66 Shc expression

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M200280200

High sensitivity mapping of methylated cytosines

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M200280200

CpG islands in vertebrate genomes

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M200280200

Tyrosine 474 of ZAP-70 is required for association with the Shc adaptor and for T-cell antigen receptor-dependent gene activation

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M200280200

Identification and Characterization of the Potential Promoter Regions of 1031 Kinds of Human Genes

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M200280200

Transcriptional repression by the methyl-CpG-binding protein MeCP2 involves a histone deacetylase complex

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M200280200

DNA methylation and chromatin modification.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M200280200

High levels of de novo methylation and altered chromatin structure at CpG islands in cell lines.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M200280200

Alterations in DNA Methylation: A Fundamental Aspect of Neoplasia

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M200280200

Regulated expression of focal adhesion kinase-related nonkinase, the autonomously expressed C-terminal domain of focal adhesion kinase

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M200280200

Fli-1b is generated by usage of differential splicing and alternative promoter

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M200280200

Differentially expressed messenger RNA isoforms of the human estrogen receptor-alpha gene are generated by alternative splicing and promoter usage

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M200280200

Human RNA-specific adenosine deaminase ADAR1 transcripts possess alternative exon 1 structures that initiate from different promoters, one constitutively active and the other interferon inducible

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M200280200

Alternative promoter usage and tissue specific expression of the mouse somatostatin receptor 2 gene

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M200280200

Alternative transcription and splicing of the human porphobilinogen deaminase gene result either in tissue-specific or in housekeeping expression.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M200280200

Epigenetic inactivation of a RAS association domain family protein from the lung tumour suppressor locus 3p21.3.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M200280200

21 January 2018

Identifiers

DOI

10.1074/JBC.M200280200

1 reference

23 September 2017

1 reference