Inhibition of the current of heterologously expressed HERG potassium channels by flecainide and comparison with quinidine, propafenone and lignocaine (Q40721914)

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scientific article published on July 2002

Language	Label	Description	Also known as
English	Inhibition of the current of heterologously expressed HERG potassium channels by flecainide and comparison with quinidine, propafenone and lignocaine	scientific article published on July 2002

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scholarly article

1 reference

Europe PubMed Central

PMC publication ID

23 September 2017

Inhibition of the current of heterologously expressed HERG potassium channels by flecainide and comparison with quinidine, propafenone and lignocaine (English)

1 reference

Europe PubMed Central

PMC publication ID

23 September 2017

author name string

Ashok A Paul

1

1 reference

Europe PubMed Central

PMC publication ID

23 September 2017

Harry J Witchel

2

1 reference

Europe PubMed Central

PMC publication ID

23 September 2017

Jules C Hancox

3

1 reference

Europe PubMed Central

PMC publication ID

23 September 2017

language of work or name

0 references

publication date

1 July 2002

1 reference

Europe PubMed Central

PMC publication ID

23 September 2017

British Journal of Pharmacology

1 reference

Europe PubMed Central

PMC publication ID

23 September 2017

136

1 reference

Europe PubMed Central

PMC publication ID

23 September 2017

5

1 reference

Europe PubMed Central

PMC publication ID

23 September 2017

717-729

1 reference

Europe PubMed Central

PMC publication ID

23 September 2017

Rate dependency of delayed rectifier currents during the guinea-pig ventricular action potential

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1573407

25 September 2017

HERG K+ channels: friend and foe.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1573407

25 September 2017

Inhibition of HERG potassium channel current by the class 1a antiarrhythmic agent disopyramide

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1573407

25 September 2017

Therapeutic drug monitoring of flecainide in serum using high-performance liquid chromatography and electrospray mass spectrometry.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1573407

25 September 2017

Familial and acquired long qt syndrome and the cardiac rapid delayed rectifier potassium current

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1573407

25 September 2017

A structural basis for drug-induced long QT syndrome

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1573407

25 September 2017

Trapping of a methanesulfonanilide by closure of the HERG potassium channel activation gate.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1573407

25 September 2017

Evolution, mechanisms, and classification of antiarrhythmic drugs: focus on class III actions

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1573407

25 September 2017

Long QT syndromes and torsade de pointes

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1573407

25 September 2017

Modulation of HERG potassium channels by extracellular magnesium and quinidine

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1573407

25 September 2017

Properties of HERG Channels Stably Expressed in HEK 293 Cells Studied at Physiological Temperature

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1573407

25 September 2017

Electrophysiological and pharmacological correspondence between Kv4.2 current and rat cardiac transient outward current

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1573407

25 September 2017

Coassembly of K(V)LQT1 and minK (IsK) proteins to form cardiac I(Ks) potassium channel

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1573407

25 September 2017

K(V)LQT1 and lsK (minK) proteins associate to form the I(Ks) cardiac potassium current

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1573407

25 September 2017

Spectrum of HERG K+-channel dysfunction in an inherited cardiac arrhythmia

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1573407

25 September 2017

The inward rectification mechanism of the HERG cardiac potassium channel

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1573407

25 September 2017

K+ channels and control of ventricular repolarization in the heart

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1573407

25 September 2017

Effects of propafenone on calcium currents in single ventricular myocytes of guinea-pig

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1573407

25 September 2017

Mechanism of flecainide's rate-dependent actions on action potential duration in canine atrial tissue

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1573407

25 September 2017

A molecular basis for cardiac arrhythmia: HERG mutations cause long QT syndrome

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1573407

25 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1573407

25 September 2017

A mechanistic link between an inherited and an acquired cardiac arrhythmia: HERG encodes the IKr potassium channel

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1573407

25 September 2017

HERG, a Human Inward Rectifier in the Voltage-Gated Potassium Channel Family

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1573407

25 September 2017

Kinetics of onset of rate-dependent effects of Class I antiarrhythmic drugs are important in determining their effects on refractoriness in guinea-pig ventricle, and provide a theoretical basis for their subclassification

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1573407

25 September 2017

Two components of cardiac delayed rectifier K+ current. Differential sensitivity to block by class III antiarrhythmic agents

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1573407

25 September 2017

Propafenone-Induced Torsade de Pointes: Cross-Reactivity with Quinidine

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1573407

25 September 2017

Time-, voltage-, and state-dependent block by quinidine of a cloned human cardiac potassium channel

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1573407

25 September 2017

Time course and voltage dependence of expressed HERG current compared with native "rapid" delayed rectifier K current during the cardiac ventricular action potential

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1573407

25 September 2017

Rapid inactivation determines the rectification and [K+]o dependence of the rapid component of the delayed rectifier K+ current in cardiac cells.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1573407

25 September 2017

High affinity open channel block by dofetilide of HERG expressed in a human cell line.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1573407

25 September 2017

Open channel block of HERG K(+) channels by vesnarinone.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1573407

17 June 2018

Blocking effects of the antiarrhythmic drug propafenone on the HERG potassium channel

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1573407

17 June 2018

Inhibition of the current of heterologously expressed HERG potassium channels by imipramine and amitriptyline

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1573407

17 June 2018

Inhibition of L-type calcium current by propafenone in single myocytes isolated from the rabbit atrioventricular node

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1573407

17 June 2018

Separation of the components of the delayed rectifier potassium current using selective blockers of IKr and IKs in guinea-pig isolated ventricular myocytes

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1573407

17 June 2018

Flecainide-induced QT prolongation and ventricular tachycardia

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1573407

17 June 2018

Comparison of intravenous mexiletine and lidocaine for the treatment of ventricular arrhythmias

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1573407

17 June 2018

QT prolongation and induction of torsades de pointe by flecainide. Apropos of a case

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1573407

17 June 2018

Inhibition of ICa in single frog cardiac cells by quinidine, flecainide, ethmozin, and ethacizin

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1573407

17 June 2018

Delayed rectifier outward K+ current is composed of two currents in guinea pig atrial cells.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1573407

17 June 2018

Differential effects on action potential duration of class IA, B and C antiarrhythmic drugs: modulation by stimulation rate and extracellular K+ concentration

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1573407

17 June 2018

Inhibitory actions of the selective serotonin re-uptake inhibitor citalopram on HERG and ventricular L-type calcium currents

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1573407

19 August 2018

Drug block of I(kr): model systems and relevance to human arrhythmias

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1573407

19 August 2018

An amino acid residue whose change by mutation affects drug binding to the HERG channel

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1573407

19 August 2018

Comparative effects of azimilide and ambasilide on the human ether-a-go-go-related gene (HERG) potassium channel.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1573407

19 August 2018

Molecular determinant of high-affinity dofetilide binding to HERG1 expressed in Xenopus oocytes: involvement of S6 sites.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1573407

19 August 2018

Characteristics of a transient outward current (sensitive to 4-aminopyridine) in Ca2+-tolerant myocytes isolated from the rabbit atrioventricular node.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1573407

19 August 2018

Two delayed rectifiers in guinea pig ventricular myocytes distinguished by tail current kinetics.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1573407

19 August 2018

Pharmacological modulation of human cardiac Na+ channels

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1573407

19 August 2018

Propafenone preferentially blocks the rapidly activating component of delayed rectifier K+ current in guinea pig ventricular myocytes. Voltage-independent and time-dependent block of the slowly activating component.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1573407

19 August 2018

Comparative investigation of the antiarrhythmic effect of propafenone (Rytmonorm) and lidocaine in patients with ventricular arrhythmias during acute myocardial infarction.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1573407

19 August 2018

An investigation of the role played by the E-4031-sensitive (rapid delayed rectifier) potassium current in isolated rabbit atrioventricular nodal and ventricular myocytes

1 reference

https://pubmed.ncbi.nlm.nih.gov/12086981

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Block of delayed rectifier potassium current, IK, by flecainide and E-4031 in cat ventricular myocytes

1 reference

https://pubmed.ncbi.nlm.nih.gov/12086981

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Differential block of cardiac delayed rectifier current by class Ic antiarrhythmic drugs: evidence for open channel block and unblock

1 reference

https://pubmed.ncbi.nlm.nih.gov/12086981

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Potassium channel blocking properties of propafenone in rabbit atrial myocytes

1 reference

https://pubmed.ncbi.nlm.nih.gov/12086981

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Modulation of flecainide's cardiac sodium channel blocking actions by extracellular sodium: a possible cellular mechanism for the action of sodium salts in flecainide cardiotoxicity

1 reference

https://pubmed.ncbi.nlm.nih.gov/12086981

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Flecainide inhibits the transient outward current in atrial myocytes isolated from the rabbit heart

1 reference

https://pubmed.ncbi.nlm.nih.gov/12086981

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Extracellular potassium modulation of drug block of IKr. Implications for torsade de pointes and reverse use-dependence

1 reference

https://pubmed.ncbi.nlm.nih.gov/12086981

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

A method for making rapid changes of superfusate whilst maintaining temperature at 37 degrees C

1 reference

https://pubmed.ncbi.nlm.nih.gov/12086981

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Comparison of the effects of class I anti-arrhythmic drugs, cibenzoline, mexiletine and flecainide, on the delayed rectifier K+ current of guinea-pig ventricular myocytes

1 reference

https://pubmed.ncbi.nlm.nih.gov/12086981

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

[Sotalol, propafenone, and flecainide: compared multiparametric analysis of ventricular repolarization in subjects without organic cardiopathy]

1 reference

https://pubmed.ncbi.nlm.nih.gov/12086981

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Effect of disopyramide on potassium currents in rabbit ventricular myocytes

1 reference

https://pubmed.ncbi.nlm.nih.gov/12086981

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Steady-state serum quinidine concentration: role in prophylactic therapy following acute myocardial infarction

1 reference

https://pubmed.ncbi.nlm.nih.gov/12086981

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Stereoselective effects of disopyramide enantiomers in humans

1 reference

https://pubmed.ncbi.nlm.nih.gov/12086981

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1038/SJ.BJP.0704784

1 reference

Europe PubMed Central

PMC publication ID

23 September 2017

PMC publication ID

1 reference

Europe PubMed Central

PMC publication ID

23 September 2017

PubMed publication ID

1 reference

Europe PubMed Central

PMC publication ID

23 September 2017

ResearchGate publication ID

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