Mechanism of tacrine block at adult human muscle nicotinic acetylcholine receptors (Q40708436)

22 September 2017

Mechanism of tacrine block at adult human muscle nicotinic acetylcholine receptors (English)

1 reference

22 September 2017

Richard J Prince

1 reference

22 September 2017

Richard A Pennington

series ordinal

1 reference

22 September 2017

Steven M Sine

series ordinal

1 reference

22 September 2017

1 September 2002

1 reference

The Journal of General Physiology

22 September 2017

1 reference

22 September 2017

120

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22 September 2017

1 reference

22 September 2017

369-393

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Lysine scanning mutagenesis delineates structural model of the nicotinic receptor ligand binding domain

22 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2229521

The anthelmintic pyrantel acts as a low efficacious agonist and an open-channel blocker of mammalian acetylcholine receptors

25 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2229521

Crystal structure of an ACh-binding protein reveals the ligand-binding domain of nicotinic receptors

25 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2229521

Tacrine interacts with different sites on nicotinic receptor subtypes in SH-SY5Y neuroblastoma and M10 cells

25 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2229521

Block of rat brain recombinant SK channels by tricyclic antidepressants and related compounds.

25 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2229521

Delimiting the binding site for quaternary ammonium lidocaine derivatives in the acetylcholine receptor channel

25 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2229521

Epibatidine activates muscle acetylcholine receptors with unique site selectivity

25 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2229521

Desensitization of mouse nicotinic acetylcholine receptor channels. A two-gate mechanism

25 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2229521

Mechanisms of barbiturate inhibition of acetylcholine receptor channels

25 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2229521

Estimating single-channel kinetic parameters from idealized patch-clamp data containing missed events

25 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2229521

Congenital myasthenic syndrome caused by decreased agonist binding affinity due to a mutation in the acetylcholine receptor epsilon subunit

25 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2229521

Block by acetylcholine of mouse muscle nicotinic receptors, stably expressed in fibroblasts

25 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2229521

Agonists block currents through acetylcholine receptor channels

25 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2229521

Relationship between membrane excitability and single channel open-close kinetics

25 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2229521

Ionic Blockage of Sodium Channels in Nerve

25 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2229521

Genetic manipulation of ion channels: a new approach to structure and mechanism

25 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2229521

Mechanisms of noncompetitive inhibition of acetylcholine-induced single-channel currents

25 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2229521

Fast events in single-channel currents activated by acetylcholine and its analogues at the frog muscle end-plate

25 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2229521

Activation of Torpedo acetylcholine receptors expressed in mouse fibroblasts. Single channel current kinetics reveal distinct agonist binding affinities

25 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2229521

Local anaesthetics transiently block currents through single acetylcholine-receptor channels

25 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2229521

Voltage jump analysis of procaine action at frog end-plate

25 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2229521

Epibatidine binds with unique site and state selectivity to muscle nicotinic acetylcholine receptors

25 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2229521

Effect of tacrine on intracellular calcium in cholinergic SN56 neuronal cells

25 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2229521

Tacrine interacts with an allosteric activator site on alpha 4 beta 2 nAChRs in M10 cells

25 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2229521

Molecular dissection of subunit interfaces in the acetylcholine receptor. Identification of residues that determine agonist selectivity

25 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2229521

Trapping of an open-channel blocker at the frog neuromuscular acetylcholine channel

25 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2229521

Activation of recombinant mouse acetylcholine receptors by acetylcholine, carbamylcholine and tetramethylammonium

25 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2229521

The location of the gate in the acetylcholine receptor channel

25 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2229521

Luminal and non-luminal non-competitive inhibitor binding sites on the nicotinic acetylcholine receptor

17 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2229521

Activation and cooperative multi-ion block of single nicotinic-acetylcholine channel currents of Ascaris muscle by the tetrahydropyrimidine anthelmintic, morantel

17 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2229521

Tetrahydroaminoacridine blocks and prolongs NMDA receptor-mediated responses in a voltage-dependent manner

17 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2229521

Voltage dependencies of the effects of chlorpromazine on the nicotinic receptor channel from mouse muscle cell line So18.

17 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2229521

End-plate channel opening and the kinetics of quinacrine (mepacrine) block

17 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2229521

On the stochastic properties of single ion channels

17 June 2018

2 references

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2229521

17 June 2018

https://api.crossref.org/works/10.1085%2FJGP.20028583

The cholinergic pharmacology of tetrahydroaminoacridine in vivo and in vitro

21 January 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2229521

Activation of acetylcholine receptors on clonal mammalian BC3H-1 cells by high concentrations of agonist.

17 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2229521

Ion channel block by acetylcholine, carbachol and suberyldicholine at the frog neuromuscular junction.

17 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2229521

Muscarinic subtype selectivity of tetrahydroaminoacridine: Possible relationship to its capricious efficacy

17 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2229521

Tetrahydroaminoacridine block of N-methyl-D-aspartate-activated cation channels in cultured hippocampal neurons

17 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2229521

An open-channel blocker interacts with adjacent turns of α-helices in the nicotinic acetylcholine receptor

17 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2229521

Desensitization of acetylcholine receptors in BC3H-1 cells

17 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2229521

A new look at the statistical model identification

17 June 2018

1 reference

https://api.crossref.org/works/10.1085%2FJGP.20028583

Tacrine and physostigmine block nicotinic receptors in Xenopus oocytes injected with Torpedo electroplaque membranes

21 January 2018

1 reference

https://api.crossref.org/works/10.1085%2FJGP.20028583

Deactivation and desensitization of mouse embryonic- and adult-type nicotinic receptor channel currents

21 January 2018

1 reference

https://api.crossref.org/works/10.1085%2FJGP.20028583

Nicotinic acetylcholine receptor at 4.6 A resolution: transverse tunnels in the channel wall

21 January 2018

1 reference

https://api.crossref.org/works/10.1085%2FJGP.20028583

The charge carried by single-channel currents of rat cultured muscle cells in the presence of local anaesthetics.

21 January 2018

1 reference

https://api.crossref.org/works/10.1085%2FJGP.20028583

Competitive potentiation of acetylcholine effects on neuronal nicotinic receptors by acetylcholinesterase-inhibiting drugs

21 January 2018

1 reference

https://api.crossref.org/works/10.1085%2FJGP.20028583

The noncompetitive inhibitor quinacrine modifies the desensitization kinetics of muscle acetylcholine receptors

21 January 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2229521

Local anesthetics and histrionicotoxin are allosteric inhibitors of the acetylcholine receptor. Studies of clonal muscle cells.

19 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2229521

Ion Channel Block by Acetylcholine, Carbachol and Suberyldicholine at the Frog Neuromuscular Junction

19 August 2018

1 reference

https://api.crossref.org/works/10.1085%2FJGP.20028583

Single acetylcholine-activated channels show burst-kinetics in presence of desensitizing concentrations of agonist

21 January 2018

1 reference

https://api.crossref.org/works/10.1085%2FJGP.20028583

Acetylcholine receptor channel imaged in the open state

21 January 2018

1 reference

https://api.crossref.org/works/10.1085%2FJGP.20028583

Voltage dependence of mouse acetylcholine receptor gating: different charge movements in di-, mono- and unliganded receptors

21 January 2018

1 reference

https://api.crossref.org/works/10.1085%2FJGP.20028583

Substance P reduces acetylcholine-induced currents in isolated bovine chromaffin cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1085%2FJGP.20028583

Recovery from the rapid desensitization of nicotinic acetylcholine receptor channels on mouse muscle

21 January 2018

1 reference

https://api.crossref.org/works/10.1085%2FJGP.20028583

A study of the desensitization produced by acetylcholine at the motor end-plate

21 January 2018

1 reference

https://api.crossref.org/works/10.1085%2FJGP.20028583

Effects of NIK-247 and tacrine on muscarinic receptor subtypes in rats

21 January 2018

1 reference

https://api.crossref.org/works/10.1085%2FJGP.20028583

Interaction of 9-amino-1,2,3,4-tetrahydroaminoacridine (THA) with human cortical nicotinic and muscarinic receptor binding in vitro

21 January 2018

1 reference

https://api.crossref.org/works/10.1085%2FJGP.20028583

21 January 2018

Identifiers

DOI

10.1085/JGP.20028583

1 reference

22 September 2017

1 reference

22 September 2017

PubMed publication ID

12198092

1 reference