High glucose potentiates palmitate-induced NO-mediated cytotoxicity through generation of superoxide in clonal beta-cell HIT-T15. (Q40639986)

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4 November 2019

title

High glucose potentiates palmitate-induced NO-mediated cytotoxicity through generation of superoxide in clonal beta-cell HIT-T15 (English)

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4 November 2019

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4 November 2019

Toshihiko Fujiwara

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4 November 2019

Jun Ohsumi

series ordinal

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4 November 2019

language of work or name

English

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publication date

1 June 2003

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4 November 2019

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4 November 2019

volume

545

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4 November 2019

issue

2-3

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4 November 2019

page(s)

219-223

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Nutrient toxicity in pancreatic beta-cell dysfunction

4 November 2019

cites work

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Fatty acids, lipotoxicity and insulin secretion

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Glucose-induced preproinsulin gene expression is inhibited by the free fatty acid palmitate

21 January 2018

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Fatty acid-induced beta cell apoptosis: a link between obesity and diabetes

21 January 2018

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Protection against lipoapoptosis of beta cells through leptin-dependent maintenance of Bcl-2 expression

21 January 2018

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Lipoapoptosis in beta-cells of obese prediabetic fa/fa rats. Role of serine palmitoyltransferase overexpression

21 January 2018

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Prolonged exposure to free fatty acids has cytostatic and pro-apoptotic effects on human pancreatic islets: evidence that beta-cell death is caspase mediated, partially dependent on ceramide pathway, and Bcl-2 regulated.

21 January 2018

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Inhibition of insulin gene expression by long-term exposure of pancreatic beta cells to palmitate is dependent on the presence of a stimulatory glucose concentration

21 January 2018

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Increased lipogenic capacity of the islets of obese rats: a role in the pathogenesis of NIDDM.

21 January 2018

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Lipotoxicity of the pancreatic beta-cell is associated with glucose-dependent esterification of fatty acids into neutral lipids

21 January 2018

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Normalizing mitochondrial superoxide production blocks three pathways of hyperglycaemic damage

21 January 2018

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Chronic exposure to free fatty acids or high glucose induces apoptosis in rat pancreatic islets: possible role of oxidative stress.

21 January 2018

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Hyperglycemia-induced mitochondrial superoxide overproduction activates the hexosamine pathway and induces plasminogen activator inhibitor-1 expression by increasing Sp1 glycosylation

21 January 2018

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Activation of the hexosamine pathway leads to deterioration of pancreatic beta-cell function through the induction of oxidative stress

21 January 2018

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Cytosolic O-GlcNAc accumulation is not involved in beta-cell death in HIT-T15 or Min6.

21 January 2018

1 reference

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Involvement of protein kinase C beta 2 in c-myc induction by high glucose in pancreatic beta-cells

21 January 2018

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Poly (ADP-ribose) polymerase, nitric oxide and cell death

21 January 2018

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Apoptotic cell death triggered by nitric oxide in pancreatic beta-cells

21 January 2018

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Evidence for the involvement of cGMP and protein kinase G in nitric oxide-induced apoptosis in the pancreatic B-cell line, HIT-T15.

21 January 2018

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Mutagenesis of palmitoylation sites in endothelial nitric oxide synthase identifies a novel motif for dual acylation and subcellular targeting

21 January 2018

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Inverse relationship between cytotoxicity of free fatty acids in pancreatic islet cells and cellular triglyceride accumulation.

21 January 2018

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Peroxynitrite: a two-faced metabolite of nitric oxide

21 January 2018

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DNA strand breakage and activation of poly-ADP ribosyltransferase: a cytotoxic pathway triggered by peroxynitrite

21 January 2018

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Nitric oxide and superoxide, a deadly cocktail.

21 January 2018

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Metabolic consequence of long-term exposure of pancreatic beta cells to free fatty acid with special reference to glucose insensitivity

21 January 2018

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Enhanced de novo lipogenesis in the leptin-unresponsive pancreatic islets of prediabetic Zucker diabetic fatty rats: role in the pathogenesis of lipotoxic diabetes

7 January 2021

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Sensitivity of human pancreatic islets to peroxynitrite-induced cell dysfunction and death

7 January 2021

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10.1016/S0014-5793(03)00534-9

7 January 2021

Identifiers

DOI

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4 November 2019

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