DOT1L Activity Promotes Proliferation and Protects Cortical Neural Stem Cells from Activation of ATF4-DDIT3-Mediated ER Stress In Vitro (Q40615754)

22 September 2017

title

DOT1L Activity Promotes Proliferation and Protects Cortical Neural Stem Cells from Activation of ATF4-DDIT3-Mediated ER Stress In Vitro (English)

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22 September 2017

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Deborah Roidl

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22 September 2017

Patrick P Bovio

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22 September 2017

Alejandro Villarreal

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22 September 2017

Stefanie Heidrich

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22 September 2017

Sigrun Nestel

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22 September 2017

Ulrike Boenisch

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22 September 2017

Tanja Vogel

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22 September 2017

publication date

24 August 2015

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22 September 2017

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22 September 2017

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22 September 2017

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22 September 2017

page(s)

233-245

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Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International

22 September 2017

start time

10 November 2021

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April 2022 Public Data File from Crossref

copyrighted

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cites work

Dot1 and histone H3K79 methylation in natural telomeric and HM silencing

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Evidence that the histone methyltransferase Dot1 mediates global genomic repair by methylating histone H3 on lysine 79.

21 January 2018

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Methylated lysine 79 of histone H3 targets 53BP1 to DNA double-strand breaks

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Histone methyltransferase DOT1L drives recovery of gene expression after a genotoxic attack.

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Deficiency of H3K79 histone methyltransferase Dot1-like protein (DOT1L) inhibits cell proliferation

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Dot1-dependent histone H3K79 methylation promotes activation of the Mek1 meiotic checkpoint effector kinase by regulating the Hop1 adaptor

21 January 2018

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The histone methyltransferase Dot1/DOT1L as a critical regulator of the cell cycle

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The histone H3K79 methyltransferase Dot1L is essential for mammalian development and heterochromatin structure

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ES cell cycle progression and differentiation require the action of the histone methyltransferase Dot1L.

21 January 2018

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DOT1L regulates dystrophin expression and is critical for cardiac function

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Early mammalian erythropoiesis requires the Dot1L methyltransferase

21 January 2018

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Requirement for Dot1l in murine postnatal hematopoiesis and leukemogenesis by MLL translocation.

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DOT1L-mediated H3K79 methylation in chromatin is dispensable for Wnt pathway-specific and other intestinal epithelial functions

21 January 2018

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Chromatin-modifying enzymes as modulators of reprogramming

21 January 2018

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Human histone H3K79 methyltransferase DOT1L protein [corrected] binds actively transcribing RNA polymerase II to regulate gene expression

21 January 2018

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Af9/Mllt3 interferes with Tbr1 expression through epigenetic modification of histone H3K79 during development of the cerebral cortex

21 January 2018

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Dot1a-AF9 complex mediates histone H3 Lys-79 hypermethylation and repression of ENaCalpha in an aldosterone-sensitive manner

21 January 2018

1 reference

Linking H3K79 trimethylation to Wnt signaling through a novel Dot1-containing complex (DotCom)

21 January 2018

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Characterization of the DOT1L network: implications of diverse roles for DOT1L

21 January 2018

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Histone modification mapping in human brain reveals aberrant expression of histone H3 lysine 79 dimethylation in neural tube defects

21 January 2018

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The Tudor protein survival motor neuron (SMN) is a chromatin-binding protein that interacts with methylated lysine 79 of histone H3.

21 January 2018

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Transforming growth factor beta promotes neuronal cell fate of mouse cortical and hippocampal progenitors in vitro and in vivo: identification of Nedd9 as an essential signaling component

21 January 2018

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Fast gapped-read alignment with Bowtie 2

21 January 2018

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Model-based analysis of ChIP-Seq (MACS)

21 January 2018

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Catalytic site remodelling of the DOT1L methyltransferase by selective inhibitors

21 January 2018

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Chemically ubiquitylated histone H2B stimulates hDot1L-mediated intranucleosomal methylation

21 January 2018

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Selective killing of mixed lineage leukemia cells by a potent small-molecule DOT1L inhibitor.

21 January 2018

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Potent inhibition of DOT1L as treatment of MLL-fusion leukemia

21 January 2018

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ER stress-induced cell death mechanisms

21 January 2018

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Identification of histone methylation multiplicities patterns in the brain of senescence-accelerated prone mouse 8.

21 January 2018

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The histone H2B-specific ubiquitin ligase RNF20/hBRE1 acts as a putative tumor suppressor through selective regulation of gene expression

21 January 2018

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Monoubiquitinated H2B is associated with the transcribed region of highly expressed genes in human cells

21 January 2018

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Histone H2B monoubiquitination functions cooperatively with FACT to regulate elongation by RNA polymerase II

21 January 2018

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Targeted disruption of the activating transcription factor 4 gene results in severe fetal anemia in mice.

21 January 2018

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The unfolded protein response governs integrity of the haematopoietic stem-cell pool during stress.

21 January 2018

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Induction of unfolded protein response during neuronal induction of rat bone marrow stromal cells and mouse embryonic stem cells

21 January 2018

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Aberrant neuronal differentiation and inhibition of dendrite outgrowth resulting from endoplasmic reticulum stress.

21 January 2018

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atf4 promotes β-catenin expression and osteoblastic differentiation of bone marrow mesenchymal stem cells

21 January 2018

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Stress-induced C/EBP homology protein (CHOP) represses MyoD transcription to delay myoblast differentiation

21 January 2018

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Roles of CHOP/GADD153 in endoplasmic reticulum stress

21 January 2018

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Dynamic recruitment of transcription factors and epigenetic changes on the ER stress response gene promoters

21 January 2018

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Histone H3K4 methyltransferase Mll1 regulates protein glycosylation and tunicamycin-induced apoptosis through transcriptional regulation

21 January 2018

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A dual role for SAGA-associated factor 29 (SGF29) in ER stress survival by coordination of both histone H3 acetylation and histone H3 lysine-4 trimethylation

21 January 2018

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Bat3 facilitates H3K79 dimethylation by DOT1L and promotes DNA damage-induced 53BP1 foci at G1/G2 cell-cycle phases

21 January 2018

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A ubiquitin-like domain recruits an oligomeric chaperone to a retrotranslocation complex in endoplasmic reticulum-associated degradation

21 January 2018

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Axonally synthesized ATF4 transmits a neurodegenerative signal across brain regions.

21 January 2018

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Activation of gadd153 expression through transient cerebral ischemia: evidence that ischemia causes endoplasmic reticulum dysfunction

21 January 2018

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Reduction in embryonic malformations and alleviation of endoplasmic reticulum stress by nitric oxide synthase inhibition in diabetic embryopathy.

21 January 2018

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21 January 2018

Identifiers

DOI

10.1002/STEM.2187

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22 September 2017

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