Insulin receptor substrate-2 proteasomal degradation mediated by a mammalian target of rapamycin (mTOR)-induced negative feedback down-regulates protein kinase B-mediated signaling pathway in beta-cells (Q40493551)

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English	Insulin receptor substrate-2 proteasomal degradation mediated by a mammalian target of rapamycin (mTOR)-induced negative feedback down-regulates protein kinase B-mediated signaling pathway in beta-cells	scientific article

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scholarly article

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Europe PubMed Central

PubMed publication ID

21 September 2017

Insulin receptor substrate-2 proteasomal degradation mediated by a mammalian target of rapamycin (mTOR)-induced negative feedback down-regulates protein kinase B-mediated signaling pathway in beta-cells (English)

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Europe PubMed Central

PubMed publication ID

21 September 2017

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author name string

Isabelle Briaud

1

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Europe PubMed Central

PubMed publication ID

21 September 2017

Lorna M Dickson

2

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Europe PubMed Central

PubMed publication ID

21 September 2017

Melissa K Lingohr

3

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Europe PubMed Central

PubMed publication ID

21 September 2017

Jill F McCuaig

4

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Europe PubMed Central

PubMed publication ID

21 September 2017

John C Lawrence

5

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Europe PubMed Central

PubMed publication ID

21 September 2017

Christopher J Rhodes

6

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Europe PubMed Central

PubMed publication ID

21 September 2017

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publication date

9 November 2004

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Europe PubMed Central

PubMed publication ID

21 September 2017

Journal of Biological Chemistry

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Europe PubMed Central

PubMed publication ID

21 September 2017

280

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Europe PubMed Central

PubMed publication ID

21 September 2017

3

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Europe PubMed Central

PubMed publication ID

21 September 2017

2282-2293

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Europe PubMed Central

PubMed publication ID

21 September 2017

Pancreatic beta-cell growth and survival--a role in obesity-linked type 2 diabetes?

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M412179200

21 January 2018

Two New Substrates in Insulin Signaling, IRS5/DOK4 and IRS6/DOK5

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M412179200

21 January 2018

Disruption of IRS-2 causes type 2 diabetes in mice

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M412179200

21 January 2018

Activation of IRS-2-mediated signal transduction by IGF-1, but not TGF-alpha or EGF, augments pancreatic beta-cell proliferation

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M412179200

21 January 2018

IRS-3 inhibits IRS-2-mediated signaling in pancreatic beta-cells

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M412179200

21 January 2018

Decreasing IRS-2 expression in pancreatic β-cells (INS-1) promotes apoptosis, which can be compensated for by introduction of IRS-4 expression

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M412179200

21 January 2018

A domain mimic increases DeltaF508 CFTR trafficking and restores cAMP-stimulated anion secretion in cystic fibrosis epithelia

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M412179200

21 January 2018

Beta-cell deficit and increased beta-cell apoptosis in humans with type 2 diabetes

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M412179200

21 January 2018

Disruption of insulin receptor substrate 2 causes type 2 diabetes because of liver insulin resistance and lack of compensatory beta-cell hyperplasia.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M412179200

21 January 2018

Minireview: Secondary beta-cell failure in type 2 diabetes--a convergence of glucotoxicity and lipotoxicity

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M412179200

21 January 2018

Diseases of liporegulation: new perspective on obesity and related disorders

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M412179200

21 January 2018

Hyperglycemia-induced beta-cell apoptosis in pancreatic islets of Psammomys obesus during development of diabetes.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M412179200

21 January 2018

Glucose and tolbutamide induce apoptosis in pancreatic beta-cells. A process dependent on intracellular Ca2+ concentration

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M412179200

21 January 2018

Glucose induces beta-cell apoptosis via upregulation of the Fas receptor in human islets

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M412179200

21 January 2018

Monounsaturated fatty acids prevent the deleterious effects of palmitate and high glucose on human pancreatic beta-cell turnover and function

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M412179200

21 January 2018

Inverse relationship between cytotoxicity of free fatty acids in pancreatic islet cells and cellular triglyceride accumulation.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M412179200

21 January 2018

Protein kinase B/Akt prevents fatty acid-induced apoptosis in pancreatic beta-cells (INS-1).

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M412179200

21 January 2018

Free fatty acid-induced inhibition of glucose and insulin-like growth factor I-induced deoxyribonucleic acid synthesis in the pancreatic beta-cell line INS-1.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M412179200

21 January 2018

Cellular mechanism of nutritionally induced insulin resistance in Psammomys obesus: overexpression of protein kinase Cepsilon in skeletal muscle precedes the onset of hyperinsulinemia and hyperglycemia

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M412179200

21 January 2018

Serine/threonine phosphorylation of IRS-1 triggers its degradation: possible regulation by tyrosine phosphorylation

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M412179200

21 January 2018

Differential activation of protein kinase B and p70(S6)K by glucose and insulin-like growth factor 1 in pancreatic beta-cells (INS-1).

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M412179200

21 January 2018

Differential activation mechanisms of Erk-1/2 and p70(S6K) by glucose in pancreatic beta-cells

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M412179200

21 January 2018

cAMP-dependent protein kinase and Ca2+ influx through L-type voltage-gated calcium channels mediate Raf-independent activation of extracellular regulated kinase in response to glucagon-like peptide-1 in pancreatic beta-cells

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M412179200

21 January 2018

Metabolic and autocrine regulation of the mammalian target of rapamycin by pancreatic beta-cells

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M412179200

21 January 2018

Metabolic regulation by leucine of translation initiation through the mTOR-signaling pathway by pancreatic beta-cells

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M412179200

21 January 2018

Hypoinsulinaemia, glucose intolerance and diminished beta-cell size in S6K1-deficient mice

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M412179200

21 January 2018

TOR signalling and control of cell growth

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M412179200

21 January 2018

Insulin-induced insulin receptor substrate-1 degradation is mediated by the proteasome degradation pathway.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M412179200

21 January 2018

Phosphoinositide 3-kinase-mediated reduction of insulin receptor substrate-1/2 protein expression via different mechanisms contributes to the insulin-induced desensitization of its signaling pathways in L6 muscle cells

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M412179200

21 January 2018

Establishment of 2-mercaptoethanol-dependent differentiated insulin-secreting cell lines

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M412179200

21 January 2018

Control of p70 s6 kinase by kinase activity of FRAP in vivo

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M412179200

21 January 2018

Phosphorylation of the translational repressor PHAS-I by the mammalian target of rapamycin

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M412179200

21 January 2018

The mammalian target of rapamycin phosphorylates sites having a (Ser/Thr)-Pro motif and is activated by antibodies to a region near its COOH terminus

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M412179200

21 January 2018

The rapamycin-binding domain governs substrate selectivity by the mammalian target of rapamycin

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M412179200

21 January 2018

A simplified system for generating recombinant adenoviruses

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M412179200

21 January 2018

Regulation of insulin/insulin-like growth factor-1 signaling by proteasome-mediated degradation of insulin receptor substrate-2.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M412179200

21 January 2018

SOCS-1 and SOCS-3 block insulin signaling by ubiquitin-mediated degradation of IRS1 and IRS2

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M412179200

21 January 2018

Caspases: enemies within

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M412179200

21 January 2018

Modulation of insulin receptor substrate-1 tyrosine phosphorylation by an Akt/phosphatidylinositol 3-kinase pathway

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M412179200

21 January 2018

A molecular basis for insulin resistance. Elevated serine/threonine phosphorylation of IRS-1 and IRS-2 inhibits their binding to the juxtamembrane region of the insulin receptor and impairs their ability to undergo insulin-induced tyrosine phosphory

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M412179200

21 January 2018

The c-Jun NH(2)-terminal kinase promotes insulin resistance during association with insulin receptor substrate-1 and phosphorylation of Ser(307)

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M412179200

21 January 2018

Mammalian target of rapamycin pathway regulates insulin signaling via subcellular redistribution of insulin receptor substrate 1 and integrates nutritional signals and metabolic signals of insulin

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M412179200

21 January 2018

Modulation of insulin receptor substrate-1 tyrosine phosphorylation and function by mitogen-activated protein kinase

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M412179200

21 January 2018

mTOR interacts with raptor to form a nutrient-sensitive complex that signals to the cell growth machinery

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M412179200

21 January 2018

Raptor, a binding partner of target of rapamycin (TOR), mediates TOR action

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M412179200

21 January 2018

Insulin-like growth factor I (IGF-I)-stimulated pancreatic beta-cell growth is glucose-dependent. Synergistic activation of insulin receptor substrate-mediated signal transduction pathways by glucose and IGF-I in INS-1 cells

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M412179200

21 January 2018

Islet transplantation in seven patients with type 1 diabetes mellitus using a glucocorticoid-free immunosuppressive regimen

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M412179200

21 January 2018

Upregulation of insulin receptor substrate-2 in pancreatic β cells prevents diabetes

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M412179200

21 January 2018

Identifiers

10.1074/JBC.M412179200

1 reference

Europe PubMed Central

PubMed publication ID

21 September 2017

PubMed publication ID

1 reference

Europe PubMed Central

PubMed publication ID

21 September 2017

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