Crystal structures of two nitroreductases from hypervirulent Clostridium difficile and functionally related interactions with the antibiotic metronidazole (Q40488232)

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English	Crystal structures of two nitroreductases from hypervirulent Clostridium difficile and functionally related interactions with the antibiotic metronidazole	scientific article

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scholarly article

1 reference

Europe PubMed Central

PMC publication ID

24 December 2017

http://europepmc.org/abstract/PMC/5079799

Crystal structures of two nitroreductases from hypervirulent Clostridium difficile and functionally related interactions with the antibiotic metronidazole (English)

1 reference

Europe PubMed Central

PMC publication ID

24 December 2017

http://europepmc.org/abstract/PMC/5079799

Clostridium difficile

0 references

0 references

crystal structure

1 reference

based on heuristic

inferred from title

author name string

Bing Wang

1

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Europe PubMed Central

PMC publication ID

24 December 2017

http://europepmc.org/abstract/PMC/5079799

Samantha M Powell

2

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Europe PubMed Central

PMC publication ID

24 December 2017

http://europepmc.org/abstract/PMC/5079799

Neda Hessami

3

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Europe PubMed Central

PMC publication ID

24 December 2017

http://europepmc.org/abstract/PMC/5079799

Fares Z Najar

4

1 reference

Europe PubMed Central

PMC publication ID

24 December 2017

http://europepmc.org/abstract/PMC/5079799

Leonard M Thomas

5

1 reference

Europe PubMed Central

PMC publication ID

24 December 2017

http://europepmc.org/abstract/PMC/5079799

Elizabeth A Karr

6

1 reference

Europe PubMed Central

PMC publication ID

24 December 2017

http://europepmc.org/abstract/PMC/5079799

Ann H West

7

1 reference

Europe PubMed Central

PMC publication ID

24 December 2017

http://europepmc.org/abstract/PMC/5079799

George B Richter-Addo

8

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Europe PubMed Central

PMC publication ID

24 December 2017

http://europepmc.org/abstract/PMC/5079799

publication date

10 September 2016

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Europe PubMed Central

PMC publication ID

24 December 2017

http://europepmc.org/abstract/PMC/5079799

1 reference

Europe PubMed Central

PMC publication ID

24 December 2017

http://europepmc.org/abstract/PMC/5079799

60

1 reference

Europe PubMed Central

PMC publication ID

24 December 2017

http://europepmc.org/abstract/PMC/5079799

32-39

1 reference

Europe PubMed Central

PMC publication ID

24 December 2017

http://europepmc.org/abstract/PMC/5079799

Processing of X-ray diffraction data collected in oscillation mode

1 reference

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15 June 2018

Therapies on the horizon for Clostridium difficile infections

1 reference

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15 June 2018

Burden of Clostridium difficile infection in the United States

1 reference

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1 reference

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CDD: NCBI's conserved domain database

1 reference

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Characterization of a stable, metronidazole-resistant Clostridium difficile clinical isolate

1 reference

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Crystal Structure of Reduced MsAcg, a Putative Nitroreductase from Mycobacterium smegmatis and a Close Homologue of Mycobacterium tuberculosis Acg

1 reference

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Structure of RdxA--an oxygen-insensitive nitroreductase essential for metronidazole activation in Helicobacter pylori

1 reference

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1 reference

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1 reference

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1 reference

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1 reference

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15 June 2018

PHENIX: a comprehensive Python-based system for macromolecular structure solution

1 reference

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15 June 2018

MolProbity: all-atom structure validation for macromolecular crystallography

1 reference

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15 June 2018

Antimicrobial resistance in Clostridium difficile.

1 reference

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15 June 2018

Phasercrystallographic software

1 reference

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15 June 2018

Treatment of Clostridium difficile-associated disease

1 reference

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15 June 2018

Reduction of polynitroaromatic compounds: the bacterial nitroreductases.

1 reference

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Crystal structure of a minimal nitroreductase, ydjA, from Escherichia coli K12 with and without FMN cofactor

1 reference

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Protein production by auto-induction in high density shaking cultures

1 reference

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Relatively poor outcome after treatment of Clostridium difficile colitis with metronidazole

1 reference

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Clostridium difficile toxins: mechanism of action and role in disease

1 reference

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15 June 2018

Coot: model-building tools for molecular graphics

1 reference

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Isolation of metronidazole-resistant Bacteroides fragilis carrying the nimA nitroreductase gene from a patient in Washington State

1 reference

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15 June 2018

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1 reference

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Clostridium difficile-associated diarrhea in adults

1 reference

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Structures of nitroreductase in three states: effects of inhibitor binding and reduction

1 reference

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1 reference

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Sequential inactivation of rdxA (HP0954) and frxA (HP0642) nitroreductase genes causes moderate and high-level metronidazole resistance in Helicobacter pylori

1 reference

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Gapped BLAST and PSI-BLAST: a new generation of protein database search programs

1 reference

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15 June 2018

Basic local alignment search tool

1 reference

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Emergence of reduced susceptibility to metronidazole in Clostridium difficile

1 reference

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20 August 2018

Structural and mechanistic studies of Escherichia coli nitroreductase with the antibiotic nitrofurazone. Reversed binding orientations in different redox states of the enzyme.

1 reference

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1 reference

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1 reference

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1 reference

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1 reference

https://pubmed.ncbi.nlm.nih.gov/27623089

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1016/J.NIOX.2016.09.003

1 reference

Europe PubMed Central

PMC publication ID

24 December 2017

http://europepmc.org/abstract/PMC/5079799

PMC publication ID

1 reference

Europe PubMed Central

PMC publication ID

24 December 2017

http://europepmc.org/abstract/PMC/5079799

PubMed publication ID

1 reference

Europe PubMed Central

PMC publication ID

24 December 2017

http://europepmc.org/abstract/PMC/5079799

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