Intramuscular administration of AAV overcomes pre-existing neutralizing antibodies in rhesus macaques. (Q40487347)

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26 March 2020

title

Intramuscular administration of AAV overcomes pre-existing neutralizing antibodies in rhesus macaques (English)

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26 March 2020

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26 March 2020

Jenny A Greig

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26 March 2020

Roberto Calcedo

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26 March 2020

Rebecca L Grant

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26 March 2020

Hui Peng

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26 March 2020

C Angelica Medina-Jaszek

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26 March 2020

Omua Ahonkhai

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26 March 2020

Qiuyue Qin

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26 March 2020

Soumitra Roy

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26 March 2020

Anna P Tretiakova

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language of work or name

English

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publication date

3 November 2016

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26 March 2020

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volume

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issue

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26 March 2020

page(s)

6323-6329

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Novel adeno-associated viruses from rhesus monkeys as vectors for human gene therapy

26 March 2020

cites work

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Phase 2 clinical trial of a recombinant adeno-associated viral vector expressing α1-antitrypsin: interim results

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Sustained transgene expression despite T lymphocyte responses in a clinical trial of rAAV1-AAT gene therapy

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AAV-mediated factor IX gene transfer to skeletal muscle in patients with severe hemophilia B.

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Vector-mediated gene transfer engenders long-lived neutralizing activity and protection against SIV infection in monkeys

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HIV-1 suppression and durable control by combining single broadly neutralizing antibodies and antiretroviral drugs in humanized mice

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Adeno-associated virus serotype 9 vectors transduce murine alveolar and nasal epithelia and can be readministered.

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7 January 2021

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Intramuscular injection of AAV8 in mice and macaques is associated with substantial hepatic targeting and transgene expression

7 January 2021

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Systematic evaluation of AAV vectors for liver directed gene transfer in murine models.

7 January 2021

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BALB/c mice show impaired hepatic tolerogenic response following AAV gene transfer to the liver

7 January 2021

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Construction and analysis of compact muscle-specific promoters for AAV vectors

7 January 2021

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Quaternary epitope specificities of anti-HIV-1 neutralizing antibodies generated in rhesus macaques infected by the simian/human immunodeficiency virus SHIVSF162P4

7 January 2021

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Successful transduction of liver in hemophilia by AAV-Factor IX and limitations imposed by the host immune response

7 January 2021

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Sustained correction of disease in naive and AAV2-pretreated hemophilia B dogs: AAV2/8-mediated, liver-directed gene therapy

7 January 2021

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AAV-expressed eCD4-Ig provides durable protection from multiple SHIV challenges

7 January 2021

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7 January 2021

Identifiers

DOI

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26 March 2020

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